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AKT1S1

https://www.creativebiomart.net/symbolsearch_AKT1S1.htm<br>PRAS40 (proline-rich Akt substrate of 40 kDa) is a protein with a prolin-rich domain and appears at about 40 kDa by SDS-PAGE. Initially it was identified as a substrate of PKB/Akt, it was later shown that it is also phosphorylated by mTORC1 (a complex including scaffold protein which is necessary for mTOR and phosphorylation of substrate by mTOR). PRAS40 binds to raptor through the mediation of TOS-motif in its structure in the same way as p70 S6 kinase and 4E-P1 do as substrates of mTOR , then PRAS40 is phosphorylated by mTORC1 at Ser-183 (human), and the phosphorylated PRAS40 will be dissociated from raptor. Therefore, it is considered that PRAS40 is involved in signal-transducing pathway through the mediation of not only PKB/Akt but also mTOR.

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AKT1S1

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  1. 2020/2/5 akt1s1 Protein, AKT1 substrate 1 (proline-rich) - Creative BioMart (/) Product Search cat#, product name, abbr, or keywords  You Position: Home (/) /  Products (/Products-gd.htm) /  akt1s1 akt1s1 (https://www.addtoany.com/share#url=https%3A%2F%2Fwww.creativebiomart.net%2Fsymbolsearch_AKT1S1.htm&title=akt1s1%20Protein%2C%20AKT1%2 rich)%20-%20Creative%20BioMart) Official Full Name AKT1 substrate 1 (proline-rich) Background PRAS40 (proline-rich Akt substrate of 40 kDa) is a protein with a prolin-rich domain and appears at about 40 kDa by SDS-PAGE. Initially it was identified as a substrate of PKB/Akt, it was later shown that it is also phosphorylated by mTORC1 (a complex including scaffold protein which is necessary for mTOR and phosphorylation of substrate by mTOR). PRAS40 binds to raptor through the mediation of TOS-motif in its structure in the same way as p70 S6 kinase and 4E-P1 do as substrates of mTOR , then PRAS40 is phosphorylated by mTORC1 at Ser-183 (human), and the phosphorylated PRAS40 will be dissociated from raptor. Therefore, it is considered that PRAS40 is involved in signal-transducing pathway through the mediation of not only PKB/Akt but also mTOR. Synonyms AKT1S1; AKT1 substrate 1 (proline-rich); Lobe; PRAS40; proline-rich AKT1 substrate 1; 40 kDa proline-rich AKT substrate; proline-rich Akt substrate, 40 kDa; OTTHUMP00000196757; PRAS40; OTTHUMP00000196758; Lobe; OTTHUMP00000196759; MGC2865; OTTHUMP00000196760; OTTHUMP00000196756; proline-rich Akt substrate of 40 kDa Recombinant Proteins Cell & Tissue Lysates Cat.#: AKT1S1-1854H Tag: His|Myc Source (Host): E. coli Species: Human Product name Recombinant Human AKT1 Substrate 1 (proline-rich), His-tagged And Myc-tagged (/description_106383_8.htm) +Inquiry (/Order.aspx?i1=(AKT1S1-1854H)Recombinant+Human+AKT1+Substrate+1+(proline-rich)%2c+His-tagged+And+Myc-tagged) Cat.#: AKT1S1-2377H Tag: N/A Source (Host): E. coli Species: Human Product name Recombinant Human AKT1 Substrate 1 (Proline-rich) (/description_7377_8.htm) +Inquiry (/Order.aspx?i1=(AKT1S1-2377H)Recombinant+Human+AKT1+Substrate+1+(Proline-rich)) Cat.#: AKT1S1-1934H Tag: GST Source (Host): E. coli Species: Human Product name Recombinant Human AKT1S1, GST-tagged (/description_392493_12.htm) +Inquiry (/Order.aspx?i1=(AKT1S1-1934H)Recombinant+Human+AKT1S1%2c+GST-tagged) https://www.creativebiomart.net/symbolsearch_AKT1S1.htm 1/3

  2. 2020/2/5 akt1s1 Protein, AKT1 substrate 1 (proline-rich) - Creative BioMart Cat.#: AKT1S1-25H Tag: Myc|DDK Source (Host): HEK293 Species: Human Product name Recombinant Human AKT1S1 protein, MYC/DDK-tagged (/recombinant-human-akt1s1-protein-mycddk-tagged-463957.htm) +Inquiry (/Order.aspx?i1=(AKT1S1-25H)Recombinant+Human+AKT1S1+protein%2c+MYC%2fDDK-tagged) Cat.#: AKT1S1-26H Tag: Myc|DDK Source (Host): HEK293 Species: Human Product name Recombinant Human AKT1S1 protein, MYC/DDK-tagged (/recombinant-human-akt1s1-protein-mycddk-tagged-463958.htm) +Inquiry (/Order.aspx?i1=(AKT1S1-26H)Recombinant+Human+AKT1S1+protein%2c+MYC%2fDDK-tagged) Cat.#: AKT1S1-27H Tag: Myc|DDK Source (Host): HEK293 Species: Human Product name Recombinant Human AKT1S1 protein, MYC/DDK-tagged (/recombinant-human-akt1s1-protein-mycddk-tagged-463959.htm) +Inquiry (/Order.aspx?i1=(AKT1S1-27H)Recombinant+Human+AKT1S1+protein%2c+MYC%2fDDK-tagged) Cat.#: AKT1S1-423H Tag: GST Source (Host): Wheat Germ Species: Human Product name Recombinant Human AKT1S1 Protein, GST-tagged (/recombinant-human-akt1s1-protein-gst-tagged-480481.htm) +Inquiry (/Order.aspx?i1=(AKT1S1-423H)Recombinant+Human+AKT1S1+Protein%2c+GST-tagged) Cat.#: AKT1S1-1508M Tag: His Source (Host): Mammalian Cells Species: Mouse Product name Recombinant Mouse AKT1S1 Protein (/recombinant-mouse-akt1s1-protein-438940.htm) +Inquiry (/Order.aspx?i1=(AKT1S1-1508M)Recombinant+Mouse+AKT1S1+Protein) Involved Pathway AKT1S1 involved in several pathways and played different roles in them. We selected most pathways AKT1S1 participated on our site, such as mTOR signaling pathway, AMPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKT1S1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site. Pathway Name Pathway Related Protein mTOR signaling pathway IKBKB; EIF4E1C; DEPDC6; VEGFAA; EIF4E2RS1; AKT3A; PIK3R1; RPS6KAL; RPS6KB1B; TNF AMPK signaling pathway IRS4; RAB11B; PFKP; PIK3R2; IRS2; CAMKK1; RPS6KB2; PPP2R3A; G6PC; FOXO3 Protein Function AKT1S1 has several biochemical functions, for example, protein binding, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKT1S1 itself. We selected most functions AKT1S1 had, and list some proteins which have the same functions with AKT1S1. You can find most of the proteins on our site. Function Related Protein https://www.creativebiomart.net/symbolsearch_AKT1S1.htm 2/3

  3. 2020/2/5 akt1s1 Protein, AKT1 substrate 1 (proline-rich) - Creative BioMart Function protein binding Related Protein SLC25A18; TRIM23; SYCE2; PWWP2B; EPHB6; TEN1; NTS; MDM2; RGP1; ADARB1 Function zinc ion binding Related Protein RNF144AB; MMP13A; RABGGTA; PDLIM4; ALAD; KPNB1; RASSF1; MARCH7; IGHMBP2; TRIM12A Interacting Protein AKT1S1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull- down and so on. We selected proteins and molecules interacted with AKT1S1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKT1S1. MTOR; RPTOR; BMH1; YWHAB; YWHAH; YWHAZ; RPS6KA5; ITGB3BP; TCEA2; q81wa0_bacan; hisJ   45-1 Ramsey Road, Shirley, NY 11967, USA   USA: 1-631-559-9269    1-516-512-3133   Europe: 44-207-097-1828   Fax: 1-631-938-8127   Email: info@creative-biomart.com (mailto:info@creative-biomart.com) Enter your email here to subscribe. Your email address here submit Easy access to products and services you need from our library via powerful searching tools. Copyright © 2007 - 2020 Creative BioMart (/). All Rights Reserved. (https://twitter.com/CreaBiomart) (http://www.facebook.com/pages/Creative-Biomart/374357745946387) (http://www.linkedin.com/company/creative-biomart) (/blog/) https://www.creativebiomart.net/symbolsearch_AKT1S1.htm 3/3

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