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Relative Tissue and Organ Radiosensitivity

Relative Tissue and Organ Radiosensitivity. TISSUE TYPES. Vegitative intermitotic tissue cells (VIMs) Differentiating intermitotic cells (DIMs) Multiple connective tissue cells (MCTs) Reverting postmitotic cells (RPMs) Fixed post mitotic cells (FPMs) .

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Relative Tissue and Organ Radiosensitivity

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  1. Relative Tissue and Organ Radiosensitivity

  2. TISSUE TYPES • Vegitative intermitotic tissue cells (VIMs) • Differentiating intermitotic cells (DIMs) • Multiple connective tissue cells (MCTs) • Reverting postmitotic cells (RPMs) • Fixed post mitotic cells (FPMs)

  3. Vegitative intermitotic tissue cells (VIMs) • Rapidly dividing, undifferentiated, have a short lifetime and are the most radiosensitive • Examples of VIMs are the basal cells of the epidermis and the crypt cells of the intestines

  4. Differentiating intermitotic cells (DIMs) • DIMs are produced by the division of VIMs; they are highly mitotic and relatively undifferentiated. DIMs are radiosensitive but not as much as VIMs • Example of a DIMs is type B spermatogonia

  5. Multiple connective tissue cells (MCTs) • Highly differentiated that still divide but not regularly • MCTs are comprised of endothelial cells (blood vessels) and fibroblasts (connective tissue) and are considered to be moderately radiosensitive

  6. Reverting postmitotic cells (RPMs) • Considered to be highly differentiated but are also long lived • These are the type of cells that the liver is made up of and are considered to be relatively radiosensitive

  7. Fixed post mitotic cells (FPMs) • Considered to be the most differentiated of all the tissue types and do not divide • These are the type of cells that make up nerves and are considered to be radioresistant

  8. Acutely responding organs • Organs that become easily inured by radiation shortly after exposure • They are easily injured because they are dependent on having a high degree of cellular proliferation • Examples of acutely responding organs are bone marrow, the gastrointestinal tract, skin, and testes

  9. Late-responding Organs • Complete opposite of acutely responding organs • The cells of these organs divide at a much slower rate • as a result injuries due to the exposure to radiation are not seen for long periods of time • Examples of late responding organs are the lungs and kidneys

  10. TEST • What are the five tissue type? • Vegitative intermitotic tissue cells (VIMs) • Differentiating intermitotic cells (DIMs) • Multiple connective tissue cells (MCTs) • Reverting postmitotic cells (RPMs) • Fixed post mitotic cells (FPMs)

  11. Which tissue type is the most radiosensitive? • Vegitative intermitotic tissue cells (VIMs)

  12. If an organ is injured shortly after receiving a dose of radiation, it is said to be: • An acutely responding organ

  13. Which tissue type is the most radioresistant and give one example. • Fixed post mitotic cells (FPMs), nerve cells

  14. Why are Fixed post mitotic cells (FPMs) radioresistant • They do not divide

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