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Web site for step-by-step Instructions

Web site for step-by-step Instructions. http://mdcune.psych.ucla.edu/modules/qtl. Web site for step-by-step Instructions. http://mdcune.psych.ucla.edu/modules/qtl SPSS Instructions 8-20-09(.pdf) SPSS_QTL Data_Template. Example data only—yours will be different. Not yer data!.

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Web site for step-by-step Instructions

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  1. Web site for step-by-stepInstructions http://mdcune.psych.ucla.edu/modules/qtl

  2. Web site for step-by-stepInstructions • http://mdcune.psych.ucla.edu/modules/qtl • SPSS Instructions 8-20-09(.pdf) • SPSS_QTL Data_Template

  3. Example data only—yours will be different.

  4. Not yer data! Variables Controlled by Regression

  5. Example data only—yours will be different.

  6. Web site for step-by-stepInstructions • http://mdcune.psych.ucla.edu/modules/qtl • Using GeneNetwork_QTL • SPSS_QTL Data_Template

  7. Web site for step-by-stepInstructions • http://mdcune.psych.ucla.edu/modules/qtl • BXD_geno Markers032609

  8. Defining a Peak and looking for SNPs • Peak is defined by a drop of 4.6 in the LRS from maximum • This is about 1 log unit • Pay particular attention to SNPs in our peak or region of interest

  9. Clickable track to corresponding display in UCSC Genome Browser. Each Small colored box represents a known gene Likelihood ratio statistic SNP Density Peak 65-85 Megabases

  10. Web site for step-by-stepInstructions • http://mdcune.psych.ucla.edu/modules/qtl • Using UCSC Genome Browser

  11. Clickable track to corresponding display in UCSC Genome Browser.

  12. Clickable genes!

  13. For Gabarapl1, Dr.G’s gene.

  14. Gene Chips DNA microarrays • Can use fluorescent cDNAs (mRNAs or RNAs) as probes. • Yield the pattern of gene expression across 2 different conditions. • Can examine many (thousands) of genes at once. • Does not give cell-by-cell resolution.

  15. Gene Chip Animation • http://www.bio.davidson.edu/courses/genomics/chip/chip.html

  16. Web site for step-by-stepInstructions • http://mdcune.psych.ucla.edu/modules/qtl • Using the Allen Brain Atlas

  17. In situ hybridization • Finding out which cell(s) express a gene by probing for mRNA. • Probes to mRNA can be made of antisense DNA or RNA (sense is control). • Probes are labeled. • Probes hybridize with specific mRNAs being made in a cell. • Can only examine expression of one or two genes at a time.

  18. Web site for step-by-stepInstructions • http://mdcune.psych.ucla.edu/modules/qtl • Using Entrez Gene

  19. Web site for step-by-stepInstructions • http://mdcune.psych.ucla.edu/modules/qtl • Using PubMed

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