Innovative Program for STEM Workforce Preparation

1. Innovative Program for STEM Workforce Preparation A ground breaking new path - An example of CSR investment by the pharmaceutical industry in education • Developed for American High Schools, adaptable for international implementation • Educational model with unlimited possibilities for adaptation to different areas of applied R&D

2. Project Description Provides students with an understanding of how STEM is applied in the making of new medicines through intense research and development. Builds understanding of R&D principles and processes and prepares for knowledge transfer from school to work. • Integrates biology, chemistry, mathematics, social sciences and language-arts • Breaks down barriers between subject areas • Adaptable to educational regional standards and objectives • Focuses on development of skills in problem identification, analysis, critical thinking, resource planning and decision making, all within a framework of team work

3. 10:th-12:th Grade IDEA Medicine & Science Theory and Practice Chemistry Biology Mathematical modeling, Data handling & statistics Mathematics Research and Development Strategic planning Ethical considerations Social Studies/ Health Care Policy Resource mgmt; Finance Market research and planning Language-Arts/ Communication HEALTHCARE MARKETPLACE INTEGRATED LEARNING AND SKILL DEVELOPMENT Concept Transfer: Business to School Pharmaceutical R&DHigh School PROBLEM SOLVING ANALYSIS CRITICAL THINKING DECISION MAKING COLLABORATION WITHIN & BETWEEN EXPERT TEAMS

4. Project Description Phase 1 - Components: • Condensed program to teach elementary theory and practice of pharmaceutical R&D with “deep dives” in biology, chemistry, ethics and practical reality-based case examples • Sequence of eleven subject area lessons centered on inquiry • Laboratory experimentation • Rich – and growing roster of supplemental subject lessons (Clinical trial design, statistical data analysis, mathematical modeling of [pharmacodynamics and –kinetics, vaccine and biologics development, etc.) • Teacher professional development (Summer Institute) • Active participation of pharmaceutical scientists • Independent evaluation

5. Course Overview Lesson 1IntroductionDiseases and Their Impact Lesson 2DiscoveryTargets and Magic Bullets Lesson 3DiscoveryScreening for Solutions Lesson 4DiscoveryThe Power of Molecules Lesson 5Preclin. DevelopmentChromatography Separation Lesson 6Preclin. DevelopmentSelecting the Best Molecule Lesson 7Clinical R&DIND andPhase I Lesson 8Clinical R&DPhase II Lesson 9Clinical R&DPhase III and NDA Lesson 10CommercializationExploring the Business of Science and Medicine Lesson 11MarketingWhere Business & Science Overlap

6. Pharmaceutical R&D Key facts Broadens understanding of the pharmaceutical R&D process • Developing a new medicine can take more than 12 years, costs $1+ billion • R&D is complex, involves many steps, many potential obstacles and decision points • High risk investment – High benefit for human health • Costs must be recouped to invest in next life-saving or life-enhancing drug • Safe and effective medicines reduce overall healthcare costs • Government regulation assures quality control

7. Project Team Program Lead: PhRMA & NSRC Steering Committee: • PhRMA members: Bristol-Myers Squibb GlaxoSmithKline Johnson &Johnson Novartis Schering-Plough Roche Wyeth • Twenty-one Schools in Twelve SDs in NJ, NY, MA, PA and IA • NJ Department of Education • Healthcare Institute of New Jersey • Biological Sciences Curriculum Study (evaluation) • Museum of Contemporary Science

8. Phase I Conclusion Summer Institute 2007 • Five-day Teacher Training event, hosted by BMS and Montgomery School District • Opening Day with Dinner Keynote by Sally Shuler, NSRC • Master Class Institute at Montgomery HS • Pharmaceutical Roundtable with partner company representation • District implementation plans logged in • Laboratory kits distributed to all participant schools • Teacher stipends paid by partner companies • Nineteen teams participated with 59 teachers • Five pharmaceutical companies, DoEd, HINJ • Press availability and favorable media coverage

9. 2007 Summer Institute Evaluation As a result of participating in the Summer Institute… • Teachers have a significantly better understanding of • the extent, and complexity of pharmaceutical R&D, • the social and economical issues faced by the industry, and • career opportunities for qualified talent • Teachers have a significantly stronger familiarity with the RxeSEARCH curriculum, • how it connects to and reflects the R&D process, and • the advantage it offers to inter-disciplinary teaching and learning of applied STEM • Teachers are confident that they can implement RxeSEARCH in their schools, and believe that the curriculum will positively influence student learning

10. Outcomes Objectives Key Stakeholders • PRIVATE SECTOR • Broaden understanding of the R&D process. Provide facts about the quest for new leads to make better medicines • Create studentinterest & readiness for industry careers • Demonstratecorporate social responsibility • Strengthenrelationship with grassroots community • SOCIETY/GENERAL PUBLIC • Provide a new model fordemonstrating relevance of STEM* to students’ lives • Prepare students for 21st century jobs • Strengthen the high-schoolexperience to make itglobally competitivethrough applied learning • PUBLIC EDUCATION SECTOR • Broadenunderstanding of the scientific enterprise • and its real-world applications • Heighten motivation for further study of STEM* • Provide deep understanding andmastery of content • Develop authentic, in depthskills in problem-solving, analysis • and critical thinkingthrough integrated learning *STEM: Science, Technology, Engineering, Mathematics