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Industrial Hygiene Applications of Portable GC-MS

Industrial Hygiene Applications of Portable GC-MS. Phil Smith, CDR, MSC, USN PhD, CIH. Objective.

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Industrial Hygiene Applications of Portable GC-MS

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  1. Industrial Hygiene Applications of Portable GC-MS Phil Smith, CDR, MSC, USN PhD, CIH

  2. Objective Provide examples where field-portable GC-MS has been used for qualitative screening that improved exposure assessment outcome and how this tool will and how this will affect the practice of prevention

  3. Exposure Assessment Exposure assessment is an important part of research and prevention (1) Researchers need to link exposures to outcomes (2) Practitioners need to understand exposures to verify if they are acceptable In both cases, unknown and unexpected exposures are undesirable

  4. Industrial Hygiene Applications of Solid Phase Microextraction • Screening unknown materials by SPME with GC-MS analysis • Screening unknown exposures by SPME with GC-MS analysis • Quantitative Exposure Sampling

  5. 2 of 3 fibers are extended for sampling; Circled area contains sorbent coating of 1 fiber

  6. Real-Time ID of CWA Analytes 1 Minute Sample Time, Passive SPME

  7. Sulfur Mustard (HD) 1 Minute SPME Sample Time

  8. Using Improved Instrumentation/Methods to Solve Exposure Problems CS Riot Control Agent, Thermal Dispersion

  9. What are we Currently Missing in Exposure Assessments? p-dichlorobenzene

  10. USS NIMITZ (CVN 68)

  11. Hazard Recognition –screening unknown materials by SPME with GC/MS analysis Formula 150 paint –incomplete MSDS information

  12. GC-MS Field Sampling for Shipboard Paint Analytes SPME Fiber

  13. Screening by Headspace SPME for Identification of Solvents in Paint SPME Sampling Headspace above paint sample GC/MS analysis, DB-1 column 35 °C to 150 °C, 3 °C/min n-butanol

  14. Indoor Air Sampling Following Terrorist Attack

  15. IAQ Sample, 16 September 2001 n-C15 Coelutes with n-C14 n-C16

  16. Crash Site SPME Air Sampling With On-Site GC/MS Analysis 30 min sample, fuel from aircraft 1:320 dilution (MeCl2 diluent) 30 min crash site sample

  17. 5 min passive SPME Sample shown here, field GC/MS analysis HCN (CS) Hapsite Analytes

  18. Exposure to Volatile Analytes from Handling Irradiated Mail Field identification was required at the point of contaminant generation to quickly answer fundamental exposure assessment questions ; numerous volatile, irritating chemicals were shown to be produced by the irradiation process

  19. Problem: Initially unknown exposures to volatile organic chemicals among legislative workers handling mail irradiated as a protection against anthrax Why use GC/MS for this problem? (1) Complex mixture with many trace components (2) Initially, composition completely unknown

  20. Initial GC-MS Instrumentation Used Typical GC air bath oven

  21. Initial screening samples showed rich mix of volatile organic compounds; switched to different column and confirmed results in the laboratory… GC-MS with Mobile Laboratory

  22. Irradiated Mail GC-MS Analyses Completed in the Lab

  23. Quantitative SPME Uptake Kinetics

  24. 10 s SPME Sample, GC-MS Analysis Undisclosed Hazrdous Ingredients

  25. Conclusions (Continued) Transportable (lab) Man-portable (Derived from Level 4) One of the most powerful quality improvements possible has repeatedly been shown to be: “understand qualitative situation first using Level-3 gear… THEN quantify” Our profession must drive (or at least participate in) development of better systems in levels 1-3

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