wto(vs)wty fl26y(vs)wty svb9y(vs)wty

1. Suraneni et al, table S7: Representative genes commonly upregulated in young transgenic (fl26y and svb9y) and old wt (wto) VPs compared to young wt (wty) VPs wto(vs)wty fl26y(vs)wty svb9y(vs)wty • in wto: 200 genes ≥2 fold in fl26y: 200 genes ≥1.7 fold; in svb9y: only 51 genes ≥1.5 fold Gene Fold Gene Fold Gene Fold Ski (Sloan-Kettering viral oncogene) 10.4 Ski 12.4 Ang 3 (angiogenin 3) 5.8 Ang 3 3.8 Ang 4 5.1, 5.1 Ang 4 3.3, 2.6 Ang 1 5.1 Ang 1 3.2 Ang 2 3.4 Ang 2 2.6 Angptl4 (angiopoietin-like 4) 1.7 Angptl4 1.7 Agtrap (angiotensin II, type I 1.6 Agtr1 1.4,1.3 receptor associated protein) (angiotensin receptor 1) Usp30 (ubiquitin-specific protease 30) 4.5 Usp30 9.6 Aldh8a1 (aldehyde dehydrogenase 3.2 Aldh8a1 2.8 Aldh8a 1.8 8 family, member A1) Gab3 (growth factor receptor bound 3.0 Gab3 7.2 protein 2-associated protein 3) Gnao1 (GTP-binding protein 3.0 Gnao1 6.5 alpha subunit) Pik3c2g (PI3K, C2 domain 2.8 Pik3c2g 1.7 containing,  polypeptide) Plxna1 (Plexin A1) 2.8 Plxna1 3.3 Plxna1 1.7 Saa2 (serum amyloid A 2) 2.6, 2.0 Saa2 2.9,2.5 Saa2 1.5, 1.5 Saa1 2.0 Saa1 2.7 Saa1 1.3 Psca (prostate stem cell antigen) 2.3 Psca 3.2 Slc25a17 2.2 Slc25a17 2.1, 1.7 Slc4a1 2.2 Slc4a1 4.4 Cxcl14 (chemokine ligand 14) 1.9 Cxcl14 1.4 Rkhd1 (ring finger (C3HC4 type) 2.1 Rkhd1 3.6 Rkhd1 1.7 and KH domain containing 1) Fxyd4 (FXYD domain-containing ion 2.0 Fxyd 3.8 transport regulator 4) Eif4e (eukaryotic translation 1.6 Eif4el3 2.0 initiation factor 4E) Igfbp6 1.6 Igfbp6 1.3 Shown are some representative genes COMMONLY upregulated in wto and/or fl26y and/or svb9y compared to wty VPs. Gene names and fold increase are indicated. Some genes showed upregulation on several probesets. Genes marked in red are commonly upregulated in all 3 sets of comparisons.