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Hormel Institute, University of Minnesota

Hormel Institute, University of Minnesota. MEMORANDUM OF AGREEMENT ESTABLISHING THE HORMEL INSTITUTE AUSTIN, MINNESOTA AS A UNIT OF THE GRADUATE SCHOOL UNIVERSITY OF MINNESOTA CERTIFICATE OF INCORPORATION AND BY LAWS OF THE HORMEL FOUNDATION AUSTIN MINNESOTA NOVEMBER 30, 1942.

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Hormel Institute, University of Minnesota

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  1. Hormel Institute, University of Minnesota

  2. MEMORANDUM OF AGREEMENT ESTABLISHING THE HORMEL INSTITUTE AUSTIN, MINNESOTA AS A UNIT OF THE GRADUATE SCHOOL UNIVERSITY OF MINNESOTA CERTIFICATE OF INCORPORATION AND BY LAWS OF THE HORMEL FOUNDATION AUSTIN MINNESOTA NOVEMBER 30, 1942

  3. Legacy of George A. Hormel and Jay C. Hormel • Jay C. Hormel resolved that the major portion of the Hormel Foundation income should benefit scientific research • “Good research means training, talent, facilities, and hard work.”

  4. Early Projects and Emphasis • preservation of foods • Development of a miniature pig for use in studying human disease • the nation’s leading center of scientific research in the field of lipids • Discovery of (and coining of the terms) omega 3 and omega 6 fatty acids and their relevance to health

  5. Dr. Zigang Dong Dr. Ralph T.Holman

  6. Unique Features of The Hormel Institute • Employs some of the world's leading scientists working on cutting edge research. • Many collaborative research partners • University of Minnesota Cancer Center • Mayo Clinic • Rutgers University • the University of Arizona • Access to hundreds of natural compounds for testing in the prevention and treatment of cancer.

  7. Hormel Institute Scientists: 1) Use the tools of molecular and cellular biology a) to evaluate changes in cancer cells b) to determine the role of mutant cancer genes in producing changes in cell function. 2) Attempt to understand the changes seen in cancer cells compared with normal cells. 3) A major focus of the researchers is the development of novel “natural” compounds that are non-toxic to normal tissues and cells but highly effective in preventing and/or treating various types of cancers.

  8. To win the war against cancer: • We must know the enemy--understand carcinogenesis. • Prevent or treat cancer by targeting specific cancer genes and/or proteins.

  9. P P P P Erk1/2 p38 kinase JNKs P Arsenic,UV,TPA EGFR PKC Rac, Rho Ras TAK Raf MKK 1-5 MKK 3/6 MKK 4/7 MEK1/2 P P AP-1 P P TCF Elk1 Jun P P TCF Elk1 ATF2 Jun Fos Jun Fos P c-fos c-jun P AP-1 Jun Jun Apoptosis Tumor target genes

  10. Biophysics Cancer Biology Cellular & Developmental Biology Cellular & Molecular Biology Nutrition & Metabolism Membrane Biochemistry

  11. Strategic Assets of the Hormel Institute, University of Minnesota A statement of our strategic assets in light of the criteria outlined in Advancing the Public Good: Securing the University’s Leadership Position in the 21st Century

  12. 1. Centrality to Mission • The Hormel Institute has achieved excellence in basic research • In the past year we were published 23 times including twice in Nature. • In the past year 43% of our submitted grant applications were funded. • Each faculty member has at least one R01 grant and in several cases more than one.

  13. POST-TRANSLATIONALMODIFICATION OF P53 IN TUMORIGENESIS Ann M. Bode and Zigang Dong

  14. POST-TRANSLATIONALMODIFICATION OF P53 IN TUMORIGENESIS Ann M. Bode and Zigang Dong Resveratrol EGCG Caffeine Theaflavins Resveratrol or caffeine induce p53 Ser 15 phosphorylation Resveratrol EGCG Caffeine Theaflavins

  15. 2. Quality, Productivity, Impact • The Hormel Institute has experienced rapid recent growth in the past three years. • Since 2002 the Hormel Institute has grown from 50 staff to over 90 staff. • National Institutes of Health (NIH) funding has tripled. • This rapid growth continues as additional faculty are being recruited.

  16. 3. Uniqueness & Comparative Advantage • The Hormel Institute has focused research on the most deadly disease; cancer. • The potential of Hormel Institute research is non-toxic, natural alternatives to chemotherapy and novel approaches to cancer prevention. • Our published and widely known research on green tea and ginger are only two examples of many more compounds that will help people prevent and treat cancer without the toxicity of chemotherapy.

  17. 4. Enhancement of Academic Synergies • The Hormel Institute has a growing portfolio of impressive collaborators: • Mayo Clinic • University of Minnesota Cancer Center • University of Arizona • Rutgers University • Our jointly sponsored symposia with the Mayo Clinic Cancer Center; Dietary Factors and Cancer Prevention and Targeting Carcinogenesis continue to inform the field of chemoprevention

  18. Agricultural Biotechnology on Natural Compounds as Anti-Cancer Agents; together we are initiating and coordinating systematic testing of hundreds of dietary factors isolated from natural agricultural sources.

  19. 5. Demand and Resources • Each additional staff position created at the Hormel Institute brings a high paying job to rural Minnesota. • The commercialization of Hormel Institute discoveries will create additional economic development and improve the quality of life for Minnesotans and the quality of health for people throughout the world. • Local economic development entities (Southern Minnesota Initiative Foundation, City of Austin and Development Corporation of Austin) understand our value and enthusiastically support the Hormel Institute.

  20. Matt Kramer, Commissioner of Department of Employment and Economic Development “I was amazed when I went down there what a jewel that facility is,” he said, “All along, the state’s bioscience initiative has focused on promoting Minnesota’s strengths. One of our strongest industries has been food manufacturing. What the Hormel Institute can do is show through their research that food compounds can play a critical role in disease management.” Gene Goddard, bioscience industry specialist with the Minnesota Department of Employment and Economic Development

  21. “What impresses me today is the open-mindedness of the researchers here.” Congressman Gil Gutknecht

  22. Senator Norm Coleman views cancer research at the Hormel Institute as “valuable and important work” and sees the jobs created here as an example of his “Rural Renaissance.”

  23. 6. Efficiency & Effectiveness There is a large return in the form of publications, grants, and intellectual property resulting from investments made in the Hormel Institute, University of Minnesota.

  24. 7. Development & Leveraging of Resources • The Hormel Institute is the legacy of Jay C. Hormel, who intended that Hormel Institute conduct research in the biomedical sciences. • The Hormel Foundation has faithfully supported the Hormel Institute since 1942. • The Hormel Foundation is the majority shareholder of the Hormel Foods Company. • The Hormel Foundation will become one of the world’s largest foundations supporting medical research in the coming decades.

  25. Hormel Institute, University of MinnesotaOutreach to Southern Minnesota • Summer Undergraduate Research Experience Program (S.U.R.E.) • Southern Minnesota Internet Group internet service provider to over 5,000 greater Minnesota customers. SMIG is endeavoring to provide wireless internet coverage for all of Austin. Wireless Austin would make Austin one of the few cities in the nation with city wide wireless access.

  26. Keys to the Future • The Hormel Institute’s aim is to build bridges that effectively span the gap between basic laboratory research and clinical application. • Next Steps • Meeting the needs created by our rapid expansion • Achieving “critical mass” for our faculty and sections

  27. “Jay Hormel would be very proud of the Institute if he were alive today” Mr. Richard Knowlton Chairman, Hormel Foundation On the occasion of the Hormel Institute’s 60th Anniversary Celebration

  28. Questions and Answers Zigang Dong, M.D., Dr.P.H. Executive Director and Hormel-Knowlton Professor Hormel Institute, University of Minnesota 801 16th Ave NE Austin, MN 55912 507-437-9600 zgdong@hi.umn.edu www.hi.umn.edu

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