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Carboxylic Acids & Derivatives

Carboxylic Acids & Derivatives. Chapters 18. Carboxylic Acid Derivatives. Physical Properties. Acidity. Problem 18.3 Page 818. Dicarboxylic Acids. *. *. *Key metabolites in the Krebs Cycle. Carboxylic Acid Preparation. Oxidation of alkenes O xidation of aldehydes

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Carboxylic Acids & Derivatives

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  1. Carboxylic Acids & Derivatives Chapters 18

  2. Carboxylic Acid Derivatives

  3. Physical Properties

  4. Acidity Problem 18.3 Page 818

  5. Dicarboxylic Acids * * *Key metabolites in the Krebs Cycle

  6. Carboxylic Acid Preparation • Oxidation of alkenes • Oxidation of aldehydes • Oxidation of 10 alcohols • Other Methods • Oxidation of other compounds • Hydrolysis of cyanohydrins and other nitriles • Carbonation of Grignard reagents

  7. Nucleophilic Addition • Aldehyde / Ketone

  8. Nucleophilic Addition - Elimination • Carboxylic Acid and Derivatives • Nucleophilic Attack • Leaving group departs • Neutralization / Stabilization

  9. Relative Reactivity of Acyl Compounds • Weaker the base the better the leaving group

  10. Acyl Chloride Preparation Reactions

  11. Carboxylic Anhydrides

  12. Nucleophilic Addition - Elimination • Esterification (Acid Catalyzed)

  13. Base-Promoted Ester Hydrolysis

  14. Nucleophilic Addition - Elimination • Synthesis of Amides

  15. Nucleophilic Addition - Elimination • Base hydrolysis of an amide

  16. Nucleophilic Addition - Elimination • Acid hydrolysis of an amide

  17. Nucleophilic Addition - Elimination • Acid hydrolysis of an amide

  18. Carboxylic Acid - Chemical Test • Acid test with blue litmus • Dissolved in aqueous sodium bicarbonate evolve carbon dioxide • Decarboxylation

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