1 / 5

CHLORIDE CHANNELS, CATION CHANNELS and VOLUME REGULATION

CHLORIDE CHANNELS, CATION CHANNELS and VOLUME REGULATION. Swelling-Activated Chloride Channels. hypertonic pipette solution. hypotonic bath solution.

celeste-aguirre
Download Presentation

CHLORIDE CHANNELS, CATION CHANNELS and VOLUME REGULATION

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. CHLORIDE CHANNELS, CATION CHANNELS and VOLUME REGULATION

  2. Swelling-Activated Chloride Channels hypertonic pipette solution hypotonic bath solution Cell swelling activates chloride channels. Loss of Cl- depolarizes Vm, activating Kv1.3 channels. The loss of KCl induces water efflux, restoring the original cell volume. Chloride channels are the trigger and Kv1.3 channels are required for regulatory volume decrease (RVD) in T cells. Lewis et al., J. Gen. Physiol. 1993

  3. Swelling-Activated Ca2+ Transient SwAC CRAC Ross and Cahalan, J. Gen. Physiol. 1995

  4. Volume Regulation (RVD)

  5. Swelling-Activated Chloride Channels are not related to multi-drug resistance (MDR) Swelling-Activated Chloride Channels in MDR Cells Cell swelling does not affect drug efflux, assessed by loss of R123. Upregulated levels of P-glycoprotein in MDR cells, but without changes in chloride conductance induced by cell swelling. Ehring et al., J. Gen. Physiol. 1994

More Related