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PEDIATRIC HEMATOLOGY BOARD REVIEW

RED CELL DISORDERS . NEONATAL ANEMIA. Hemorrhage: Twin-twin / feto-maternal transfusion, overt/external hemorrhageHemolysisImmune: ABO, Rh, minor blood group incompatibilityInfection: TORCH, sepsis, parvo virusRed cell defects: membrane disorders, enzyme deficiencies, hemoglobinopathy, micro/ma

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PEDIATRIC HEMATOLOGY BOARD REVIEW

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    1. PEDIATRIC HEMATOLOGY BOARD REVIEW Lakshmi Venkateswaran MD Assistant Professor Section of Hematology/Oncology Texas Children’s Hospital/Baylor College of Medicine June, 2010

    2. RED CELL DISORDERS

    3. NEONATAL ANEMIA Hemorrhage: Twin-twin / feto-maternal transfusion, overt/external hemorrhage Hemolysis Immune: ABO, Rh, minor blood group incompatibility Infection: TORCH, sepsis, parvo virus Red cell defects: membrane disorders, enzyme deficiencies, hemoglobinopathy, micro/macro-angiopathic hemolysis Underproduction Fanconi’s anemia Diamond Blackfan anemia Schwachman-Diamond syndrome Aase syndrome Pearson syndrome Dyskeratosis congenita Congenital Dyserythropoietic anemia

    4. IRON DEFICIENCY ANEMIA Cause: Dietary (milk based diet - esp. toddlers), blood loss (Meckel’s diverticulum, GI ulcer, polyps, hemangioma, irritation by cow’s milk protein, worm infestation), inhibition of/decreased absorption (lead poisoning, celiac disease, tropical sprue) Clinical Features: Pica, pallor, tachycardia, heart murmur, epithelial changes; chronic – impaired growth, cognitive dysfunction, altered attention span, behavior, performance Lab Features: Microcytosis (low MCV), increased RDW, anisocytosis, poikilocytosis, normal / low reticulocyte count, thrombocytosis

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