Outline

1. Korea Institute of Science and Technology InformationVisit to NeSCMalcolm AtkinsonDirectorwww.nesc.ac.uk24th March 2004

2. Outline • The National e-Science Centre • Role and mission • The e-Science Institute • The UK e-Science Programme • Funding and organisation • The UK Grid • The European dimension • The Essence of e-Science

3. NeSC Roles • Help coordinate and lead UK e-Science • Community building, training & outreach • Help establish the UK’s international role • The focus for presenting UK e-Science • Run the e-Science Institute • A meeting place • Workshops and conferences • Research visitors and events • Undertake R&D projects • Reliable middleware (OGSA-DAI, SunDCG, …) • Engage industry (IBM, Sun, Microsoft, HP, Oracle, …) • Stimulate the uptake of e-Science technology • Training Team

4. The Primary Requirement … Enabling People to Work Together on Challenging Projects: Science, Engineering & Medicine

5. Events Held(from 1 Aug 2002 to 29 Feb 2004 – 31 months) We have run 197 events (just over 6 per month): • 3 conferences (including GGF5 with 900 participants) • 20 project meetings • 23 research meetings • 61 workshops • 4 schools • 32 training sessions • 27 outreach events • 9 international meetings • 18 e-Science management meetings (though the definitions are fuzzy!) • 16,444 delegate days • 197 events • 6,825 delegates • 339 event days

7. The Website – a Resource • National e-Science Centre http://www.nesc.ac.uk/ • Mission, Background, Foundation, Locations, Staff, Resources, Projects • Register interest, Mailing lists, NeSCForge • Regional associations and Collaborations • News, Notices • Presentations and Lectures http://www.nesc.ac.uk/presentations/ • National e-Science Institute http://www.nesc.ac.uk/esi/ • Mission, Events (Future and Past) • Register for Events, Visitor Programme, GridNet • UK e-Science • Map and Index of Centres http://www.nesc.ac.uk/centres/ • Technical Papers http://www.nesc.ac.uk/technical_papers/ • Index of >100 Projects http://www.nesc.ac.uk/projects/ • Task Forces http://www.nesc.ac.uk/teams/ • General Information • Glossary, Bibliography, Who’s who Comprehensive and Growing Source of Information Widely used by UK, USA and the rest of the world

8. Web site Statistics Since going ‘live’ in 2001 to 31 Jan 2004 (figures in last week to 27 Feb 2004) • > 3.0 million successful requests (‘hits’) transferring 166 gigabytes of data (2.20 GB) • Average hits per day 3237 (5430) • Distinct files served 18,980 (2821) • … to 96,610 (3705) distinct hosts • Average data transferred per day 182 MB (typical file size about 100 kB) (322 MB)

9. Web site Statistics 2

10. Technical Reports • The Virtual Observatory as a Data Grid, Bob Mann, Sep 03 • UK Experience with OGSA, Dave Berry, Sep 03 • e-Science Gap Analysis, Geoffrey Fox, David Walker, Jun 03 • Scientific Data Mining, Integration and Visualisation, Bob Mann, Roy Williams, Malcolm Atkinson, Ken Brodlie, Amos Storkey, Chris Williams, Nov 02 • A Rough Guide to Grid Security, Mike Surridge, Sep 02 • Multi-Site Videoconferencing for the UK e-Science Programme, Stephen Booth, John Brooke, Kate Caldwell, Liz Carver, Michael Daw, David De Roure, Alan Flavell, Philippe Galvez, Brian Gilmore, Henry Hughes, Ben Juby, Ivan Judson, Jim Miller, Harvey Newman, Chris Osland, Sue Rogers, Oct 02 • Database Access and Integration Services on the Grid, Norman W Paton, Malcolm P Atkinson, Vijay Dialani, Dave Pearson, Tony Storey, Paul Watson, Feb 02 • Research Agenda for the Semantic Grid: A Future e-Science Infrastructure, David De Roure, Nicholas Jennings, Nigel Shadbolt, Dec 01 • Databases and the Grid, Paul Watson, Dec 01

11. Technical Reports • A Grid Application Framework based on Web Services Specifications and Practices, Savas Parastatidis, Jim Webber, Paul Watson, Thomas Rischbeck, Aug 03 • Grid Information Systems 2003 (Draft), Rob Allan, Dharmesh Chohan, Xiao Dong Wang, Andy Richards, Mark McKeown, John Colgrave, Matthew Dovey, Mark Baker, Steve Fisher, Dec 03 • Towards tractable toolkits for the Grid: a plea for lightweight, usable middleware, Jonathan Chin,Peter Coveney, Feb 04 • Portals and Portlets 2003, Rob Allan, Chris Awre, Mark Baker, Adrian Fish, Mar 04 • IMAGE 03: Images, Medical Analysis and Grid Environments, Dave Berry, Derek Hill, Steve Pieper, Joel Saltz, Cécile Germain-Renaud, Mar 04 • Open Issues in Grid Scheduling, Alain Andrieux, Dave Berry, Jon Garibaldi, Stephen Jarvis, Djamila Ouelhadj, Mar 04 • Data Provenance and Annotation, Peter Buneman, Michael Wilde. • e-Science Workflow Services, Matthew Addis, Dave Berry, Earl Ecklund, Carole Goble

12. Outline • The National e-Science Centre • Role and mission • The e-Science Institute • The UK e-Science Programme • Funding and organisation • The UK Grid • The European dimension • The Essence of e-Science

13. EPSRC Breakdown + Industrial Contributions UK e-Science Budget (2001-2006) Total: £213M Staff costs - Grid Resources funded separately Source: Science Budget 2003/4 – 2005/6, DTI(OST)

14. e-Science Institute Globus Alliance Grid Operations Centre Digital Curation Centre ? Open Middleware Infrastructure Institute EGEE The e-Science Centres CeSC (Cambridge)

15. Digital Curation Centre communities of practice: users curation organisations community support & outreach Collaborative Associates Network of Data Organisations management & co-ordination research collaborators services research development testbeds& tools Industry standards bodies

16. Task Forces • Directors’ Forum • Helped build a community • Engineering Task Force • Built the UK Grid • Architecture Task Force • UK Adoption of OGSA • OGSA Grid Market • Future approaches • Security Task Force • Database Task Force (now disbanded) • OGSA-DAI (www.ogsadai.org.uk) • GGF DAIS-WG • Usability Task Force

17. 1280 x CPU AIX 512 x CPU Irix HPC(x) 20 x CPU 18TB Disk Linux 64 x CPU 4TB Disk Linux The e-ScienceGrid Engineering Task Force (Contributions from e-Science Centres) Grid Support Centre / Grid Operations Centre OGSA Test Grid projects CeSC (Cambridge)

18. Cameras Access Grid Crucial for management meetings Requires IP multicast throughout the network Microphones

19. Some UK e-Health Projects • eDIaMoND (with IBM and Mirada) • Breast Cancer Project • IXI (with GSK and Philips Medical) • Information from medical images • MIAS Devices • Mobile sensors for healthcare • CLEF • Integrating medical information

20. eDiaMoND – Compute Mammograms have different appearances, depending on image settings and acquisition systems Temporal mammography Computer Aided Detection Standard Mammo Format 3D View

21. Screening Screening Ethics Screening Legal Screening Diagnosis Diagnosis Security Diagnosis Teaching Teaching Performance Training Teaching Scalability Epidemiology Epidemiology Manageability Epidemiology Epidemiology Auditability …… eDiaMoND – Non-Functional • Anonymisation Grid • Lossless Compression • Encryption • 256MB & 5 secs response • ~100 Centres • Systems Administration • Non-Repudiation

22. KCL, Imperial and Oxford http://www.ixi.org.uk

24. Automatic registration technology Rigid registration of MR and CT images of the head Inter-subject image warping

25. CLEF - Integrating information • Need high quality, integrated clinical information for: • clinical research • evidence-based health care • the clinical application of genetic and genomic research • The capture, integration, and presentation of descriptive information is a major barrier to achieving an integrated framework • Data includes: • clinical histories • radiology and pathology reports • annotations on genomic and image databases • technical literature and Web based resources

26. MIAS Devices Project • Easy Plug and Play of Sensors • Wireless connection using 802.11 • Positioning information from GPS • Mobile medical technologies on a distributed Grid Sensor bus GPS ariel

27. The European dimension • EGEE: Enabling Grids for E-Science in Europe • … and beyond • 32M Euro, 10 regions, 70 partners • Additional funding from NSF (USA) • 50% production, 30% development, and 20% dissemination and training • “The Grid Infrastructure in Europe” • Deploy a production Grid across Europe • Initially based on LHC Computing Grid

28. Examples of HealthGRID applications Grids for medical development Preparation and follow-up of medical missions in developing countries Support to local medical centres in terms of second diagnosis, patient follow-up and e-learning Clermont-Ferrand/Paris Patient data Request for 2nd diagnostic Second diagnostic Patient follow-up Interactive e-learning Video-conferences Patient data consultation Chuxiong Request for second diagnosis • The grid impact : • Improved telemedecine services • Federation of patient databases • Interactive e-learning (high bandwidth network required) Ibagué Hand surgery Medical centre 2 missions (Ibagué & Chuxiong) with the french NPO « Chaîne de l’Espoir » used as test cases

29. eHealth deployed tested on EDG under preparation DataGrid : status of biomedical applications eScience • Bio-informatics • Phylogenetics : BBE Lyon (T. Sylvestre) • Search for primers : Centrale Paris (K. Kurata) • Bio-informatics web portal : IBCP (C. Blanchet) • Parasitology : LBP Clermont, Univ B. Pascal (N. Jacq) • Data-mining on DNA chips : Karolinska (R. Médina, R. Martinez) • Geometrical protein comparison : Univ. Padova (C. Ferrari) • Medical imaging • MR image simulation : CREATIS (H. Benoit-Cattin) • Medical data and metadata management : CREATIS (J. Montagnat) • Mammographies analysis ERIC/Lyon 2 (S. Miguet, T. Tweed) • Simulation platform for PET/SPECT based on Geant4 : GATE collaboration (L. Maigne) GATE Monte-Carlo simulation platform for nuclear medecine

30. Outline • The National e-Science Centre • Role and mission • The e-Science Institute • The UK e-Science Programme • Funding and organisation • The UK Grid • The European dimension • The Essence of e-Science

31. What is e-Science? • Invention and exploitation of advanced computational methods • to generate, curate and analyse research data • From experiments, observations and simulations • Quality management, preservation and reliable evidence • to develop and explore models and simulations • Computation and data at extreme scales • Trustworthy, economic, timely and relevant results • to enable dynamic distributed virtual organisations • Facilitating collaboration with information and resource sharing • Security, reliability, accountability, manageability and agility • e-Science >> Grid & Web Services It is what you do with them that counts

32. Fundamental & Growing Assets • Understanding of Processes & Requirements • International and Multi-disciplinary Skill base • Experience composing & adapting existing technologies • and of building new components • Experience Supporting Developers and Users • Experience Establishing Virtual Organisations across Enterprise boundaries Embedded in People & Teams, Growing – they need nurture

33. Primary Multi-Enterprise Issues • Combining subsystems built independently in different enterprises • Deploying, Starting and Managing Applications and Production Operations • Using a set of combined facilities • Independently built • Autonomously managed • Developing software independently • Expecting to integrate later • All for VO communities that retain independence Assume Benefits of Shared Infrastructure: How much? One size fits all?

34. Relative Importance • What envelopes you put your messages in • How they are delivered • Infrastructure to organise a common technical platform – the foundations of communication

35. Relative Importance • What envelopes you put your messages in • How they are delivered • Infrastructure to organise a common technical platform – the foundations of communication • What information you send in your messages • Their patterns of Use - sequences that mean something • Their Contents • The Grammar and Vocabulary of Communication • Agreed Interpretations

36. Relative Importance Technical Experts • What envelopes you put your messages in • How they are delivered • Infrastructure to organise a common technical platform – the foundations of communication • What information you send in your messages • Their patterns of Use - sequences that mean something • Their Contents • The Grammar and Vocabulary of Communication • Agreed Interpretations • What you do when you get a message • The Application Code you Execute • The Middleware Services • Security, Privacy, Authorisation, Accounting, Registries, Brokers, … • Integration Services • Multi-site Hierarchical Scheduling, Data Access & Integration, … • Portals, Workflow Systems, Virtual Data, Semantic Grids • Tools to support Application Developers, Users & Operations

37. Relative Importance Domain Specialists • What envelopes you put your messages in • How they are delivered • Infrastructure to organise a common technical platform – the foundations of communication • What information you send in your messages • Their patterns of Use - sequences that mean something • Their Contents • The Grammar and Vocabulary of Communication • Agreed Interpretations • What you do when you get a message • The Application Code you Execute • The Middleware Services • Security, Privacy, Authorisation, Accounting, Registries, Brokers, … • Integration Services • Multi-site Hierarchical Scheduling, Data Access & Integration, … • Portals, Workflow Systems, Virtual Data, Semantic Grids • Tools to support Application Developers, Users & Operations • Creative Actions and Judgements of Researchers, Designers & Clinicians • Data, Models & Analyses • In Silico Experiments, Design, Diagnosis & Planning • Creating the Scientific Record

38. Where Next for e-Infrastructure • Put people and teams first • The creative force • The repository of Experience, Skills and Knowledge • Focus on Major Priorities • Developing well-defined Flexible Agreements • Embraced as standards • High-level Software Investment • Applications & Requirements led • Explore & Evolve Common & Shared Infrastructure • Recognise and respond to differences • Celebrate and support commonalities