1 / 19

Supplementary material 1 :

Supplementary material 1 : Tables and figures of representative significant functional networks identified by Ingenuity Pathway Analysis in brain cortex and hippocampus following 3, 6, and 12 h of hypoxia exposure and with NAP supplementation. .

emiko
Download Presentation

Supplementary material 1 :

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Supplementary material 1: Tables and figures of representative significant functional networks identified by Ingenuity Pathway Analysis in brain cortex and hippocampus following 3, 6, and 12 h of hypoxia exposure and with NAP supplementation.

  2. Table 1: IPA identified top functions of differentially expressed proteins after 3 h of hypoxia exposure in brain hippocampus

  3. Figure 1:Analysis of hypoxia (3 h) regulated pathways of network “Cell Death and Survival, Cellular Development, Embryonic Development”. Differentially expressed proteins from analysis of 3 hour hypoxic brain hippocampus sample were analysed by Ingenuity Pathway Analysis (IPA). Differentially regulated proteins are shown in red and green, depicting up- and down-regulation after hypoxic exposure.

  4. Figure 2:Analysis of hypoxia (3 h) regulated pathways of network “Tissue Morphology, Nucleic Acid Metabolism, Small Molecule Biochemistry”. Differentially expressed proteins from analysis of 3 hour hypoxic brain hippocampus sample were analysed by Ingenuity Pathway Analysis (IPA). Differentially regulated proteins are shown in red and green, depicting up- and down-regulation after hypoxic exposure.

  5. Table 2: IPA identified top functions of differentially expressed proteins after 3 h of hypoxia exposure with NAP supplementation in brain hippocampus

  6. Figure 3:Analysis of hypoxia (3 h with NAP supplementation) regulated pathways of network “Cellular Assembly and Organization, Neurological Disease, Hereditary Disorder”. Differentially expressed proteins from analysis of NAP supplemented 3 hour hypoxic brain hippocampus sample were analysed by Ingenuity Pathway Analysis (IPA). Differentially regulated proteins are shown in red and green, depicting up- and down-regulation after hypoxic exposure.

  7. Figure 4:Analysis of hypoxia (3 h with NAP supplementation) regulated pathways of network “DNA Replication, Recombination, and Repair, Energy Production, Nucleic Acid Metabolism”. Differentially expressed proteins from analysis of NAP supplemented 3 hour hypoxic brain hippocampus sample were analysed by Ingenuity Pathway Analysis (IPA). Differentially regulated proteins are shown in red and green, depicting up- and down-regulation after hypoxic exposure.

  8. Table 3: IPA identified top functions of differentially expressed proteins after 6 h of hypoxia exposure in brain hippocampus

  9. Figure 5:Analysis of hypoxia (6 h) regulated pathways of network “Nucleic Acid Metabolism, Small Molecule Biochemistry, Cell Death and Survival”. Differentially expressed proteins from analysis of 6 hour hypoxic brain hippocampus sample were analysed by Ingenuity Pathway Analysis (IPA). Differentially regulated proteins are shown in red and green, depicting up- and down-regulation after hypoxic exposure.

  10. Figure 6:Analysis of hypoxia (6 h) regulated pathways of network “Drug Metabolism, Protein Synthesis, Developmental Disorder”. Differentially expressed proteins from analysis of 6 hour hypoxic brain hippocampus sample were analysed by Ingenuity Pathway Analysis (IPA). Differentially regulated proteins are shown in red and green, depicting up- and down-regulation after hypoxic exposure.

  11. Table 4: IPA identified top functions of differentially expressed proteins after 6 h of hypoxia exposure with NAP supplimentation in brain hippocampus

  12. Figure 7:Analysis of hypoxia (6 h with NAP supplementation) regulated pathways of network “Cell Death and Survival, Nucleic Acid Metabolism, Small Molecule Biochemistry”. Differentially expressed proteins from analysis of NAP supplemented 6 hour hypoxic brain hippocampus sample were analysed by Ingenuity Pathway Analysis (IPA). Differentially regulated proteins are shown in red and green, depicting up- and down-regulation after hypoxic exposure.

  13. Figure 8:Analysis of hypoxia (6 h with NAP supplementation) regulated pathways of network “Nucleic Acid Metabolism, Small Molecule Biochemistry, DNA Replication, Recombination, and Repair”. Differentially expressed proteins from analysis of NAP supplemented 6 hour hypoxic brain hippocampus sample were analysed by Ingenuity Pathway Analysis (IPA). Differentially regulated proteins are shown in red and green, depicting up- and down-regulation after hypoxic exposure.

  14. Table 5: IPA identified top functions of differentially expressed proteins after 12 h of hypoxia exposure in brain hippocampus

  15. Figure 9:Analysis of hypoxia (12 h) regulated pathways of network “Free Radical Scavenging, Molecular Transport, Nucleic Acid Metabolism”. Differentially expressed proteins from analysis of 12 hour hypoxic brain hippocampus sample were analysed by Ingenuity Pathway Analysis (IPA). Differentially regulated proteins are shown in red and green, depicting up- and down-regulation after hypoxic exposure.

  16. Figure 10:Analysis of hypoxia (12 h) regulated pathways of network “Nucleic Acid Metabolism, Small Molecule Biochemistry, DNA Replication, Recombination, and Repair”. Differentially expressed proteins from analysis of 12 hour hypoxic brain hippocampus sample were analysed by Ingenuity Pathway Analysis (IPA). Differentially regulated proteins are shown in red and green, depicting up- and down-regulation after hypoxic exposure.

  17. Table 6: IPA identified top functions of differentially expressed proteins after 12 h of hypoxia exposure with NAP supplementation in brain hippocampus

  18. Figure 11:Analysis of hypoxia (12 h with NAP supplementation) regulated pathways of network “Free Radical Scavenging, Molecular Transport, Cancer”. Differentially expressed proteins from analysis of NAP supplemented 12 hour hypoxic brain hippocampus sample were analysed by Ingenuity Pathway Analysis (IPA). Differentially regulated proteins are shown in red and green, depicting up- and down-regulation after hypoxic exposure.

  19. Figure 12:Analysis of hypoxia (12 h with NAP supplementation) regulated pathways of network “Tissue Morphology, Cellular Assembly and Organization, Cellular Growth and Proliferation”. Differentially expressed proteins from analysis of NAP supplemented 12 hour hypoxic brain hippocampus sample were analysed by Ingenuity Pathway Analysis (IPA). Differentially regulated proteins are shown in red and green, depicting up- and down-regulation after hypoxic exposure.

More Related