1 / 6

Autosomal Dominance Inheritance

Autosomal Dominance Inheritance. What’s an Autosome?. Autosome : Non sex chromosome Ex: Autosomal disorders: gene for the disease is found on chromosomes 1-22 Autosomal Recessive Inheritance Must inherit two copies of the disorder to be affected Healthy is dominant (HH or Hh )

fauna
Download Presentation

Autosomal Dominance Inheritance

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Autosomal Dominance Inheritance

  2. What’s an Autosome? • Autosome: Non sex chromosome • Ex: Autosomal disorders: gene for the disease is found on chromosomes 1-22 • Autosomal Recessive Inheritance • Must inherit two copies of the disorder to be affected • Healthy is dominant (HH or Hh) • Disease is recessive (hh) • Ex: Cystic fibrosis, PKU, Albinism, Sickle cell anemia • Autosomal Dominance Inheritance • Only need to inherit one copy of the disorder to be affected • Disease is dominant (HH or Hh) • Healthy is recessive (hh) • Ex: Familial hypercholesterolemia (also called FH), Huntington’s disease, Neurofibromatosis

  3. Autosomal Dominance Inheritance • Disease is dominant (HH or Hh) • Homozygous dominant: early death and don’t survive to reproduce • Heterozygous live into adulthood • Healthy is recessive (hh) • ex: Paul has familial hypercholesterolemia and Stacy is healthy. The two have 3 children. After testing, the middle child is the only healthy child. Hh hh h h Paul Stacy H h H h Key H = FH disease h= healthy H disease disease Hh hh Hh h h h h h healthy healthy

  4. Autosomal Dominance Inheritance • Huntington’s disease is a dominant disorder found on chromosome 4. Betty and Marcus met at a support clinic they have been attending to help them cope with the knowledge of their illness with Huntington’s disease. They would like to know the risk of having a healthy child, now that Betty is pregnant. Hh Hh H h Marcus Betty H H H h Key H = Huntington’s disease h = healthy H Disease (severe) disease ? H h h h h disease healthy

  5. Woody Guthrie: This Land is Made for You and Me

  6. Video about Huntington's disease • Autosomal dominant disorder • Brain cells start to die in late 30’s • Causes uncontrollable muscle jerking • Death usually in 40’s-50’s • No treatments Click if YouTube video doesn’t work

More Related