Anti-Obesity Powder: Cetilistat Powder vs Orlistat Powder - AAS

1. Email: aas11@aasraw.com Whatsapp:+8618928439036 Anti-Obesity powder: Cetilistat powder vs Orlistat powder 1. Cetilistat powder............................................................................................................................. 1 2. Orlistat powder................................................................................................................................2 3. Cetilistat Dosage .............................................................................................................................3 4. Orlistat Dosage................................................................................................................................4 5. Cetilistat powder review................................................................................................................. 6 6. Orlistat powder review....................................................................................................................7 7. Cetilistat side effects....................................................................................................................... 8 8. Orlistat side effects..........................................................................................................................8 9. Cetilistat powder Better Tolerated Than Orlistat powder............................................................ 10 10. Buy Anti-Obesity powder online.................................................................................................12 Anti-Obesity powder supplier--AASraw....................................................................................12 Anti-Obesity powder from AASraw...........................................................................................13 1. Cetilistat powder Cetilistat powder is an inhibitor of pancreatic lipase, an enzyme that breaks down triglycerides in the intestine. Without this enzyme, triglycerides from the diet are prevented from being hydrolyzed into absorbable free fatty acids and are left to be excreted undigested. This drug, while similar to the currently FDA-approved drug orlistat powder, may have a more tolerable side-effect profile due to a different molecular structure. A phase 2 trial studied 612 obese, diabetic subjects with a BMI of 28 to 45 kg/m2 over a 12-week treatment period. Cetilistat 80 and 120 mg promoted significant weight loss compared with placebo (3.85 kg and 4.32 kg vs. 2.86 kg, respectively). Cetilistat-induced weight loss was similar to the weight loss achieved with orlistat powder (3.78 kg). Cetilistat powder was well tolerated and showed fewer discontinuations due to adverse events than in the placebo and orlistat groups. Given that discontinuation in the orlistat powder group was significantly worse than in the 120 mg cetilistat powder and placebo groups, and was entirely due to gastrointestinal adverse events, cetilistat powder may become a preferred lipase inhibitor for achieving weight loss . Phase 3 trials of cetilistat powder are currently in progress in Japan. 1

2. Email: aas11@aasraw.com Whatsapp:+8618928439036 2. Orlistat powder Orlistat powder is a potent and reversible gastrointestinal lipase inhibitor preventing dietary fat absorption by 30% by inhibiting pancreatic and gastric lipase. Orlistat powder was approved in 1998 and is currently the only available drug for the long-term management of obesity. The prescribed dose is 120 mg capsule 3 times daily, and a half dose (60 mg) is available over-the-counter in some countries, including the U.S. The efficacy of orlistat powder for weight loss has been reported in several RCTs for the long-term management of obesity (approximately 4 years). In meta-analyses of 12 and 15 trials, the mean difference in weight loss due to orlistat was -2.59 kg (95% CI, -3.46 to -1.74 kg) at 6 months and -2.9 kg (-3.2 to -2.5 kg) at 12 months, which was more than the placebo. The beneficial effect on body weight is sufficient to improve several cardiometabolic parameters, including waist circumference, blood pressure, blood glucose levels, and lipid profiles. In a meta-analysis which included 15 studies of approximately 10,995 participants who were treated with orlistat powder or placebo for at least 6 to 12 months, treatment with orlistat powder was associated with a significant decrease in total cholesterol after adjustment for weight loss, which indicates orlistat powder is a useful adjunctive tool for improving cardiovascular risk factor profiles in obese patients. Orlistat powder also reduced the incidence of type 2 diabetes from 9.0% to 6.2% (HR, 0.63; 95% CI, 0.46 to 0.86) in a longer 4-year trial. 2

3. Email: aas11@aasraw.com Whatsapp:+8618928439036 Among Korean obese patients receiving orlistat powder for 24 weeks, the mean weight change from baseline was -2.8 kg. Treatment with orlistat powder also improved several metabolic parameters. There were significant improvements of glycemic control (HbA1c, -0.87%; P<0.01), fasting insulin, total cholesterol, LDL-C (P<0.001), waist circumference (-5.48±0.54 cm, P<0.001), systolic blood pressure and diastolic blood pressure (P=0.000), without serious side effects. The most common side effects of orlistat powder are gastrointestinal and include diarrhea, fecal incontinence, oily spotting, flatulence, bloating, and dyspepsia. As a result of the adverse effects, orlistat powder may not be well tolerated. However, the side effects tend to occur early and can be reduced as patients learn how to avoid fat-rich diets. Recently, serious liver injury has been reported over the past 10 years. Between 1999 and 2008, the U.S. FDA received 32 reports of severe liver injury, including 6 cases of liver failure in patients using orlistat powder, which prompted the U.S. FDA to treatment safety. The review identified a total of 13 cases of severe liver injury, reported between April 1999 and August 2009 out of an estimated 40 million people worldwide who had used Xenical or Alli. The U.S. FDA advised healthcare professionals to continue prescription of orlistat powder in August 2009, because severe liver injury was rare. However, a review in May 2010 led to a label revision and the addition of a warning of severe liver injury to educate the public regarding the signs and symptoms of liver injury. undertake a review of orlistat's 3. Cetilistat Dosage Cetislim (Cetilistat) powder is provided as 60mg strength capsules for administration orally. The medicine is taken with meals to ensure that it can work while the food is being digested, so that the absorption of fat from the diet can be effectively reduced. Your physician will advise you on how much medicine to take with each dose, as well as the required daily dosage. It is very 3

4. Email: aas11@aasraw.com Whatsapp:+8618928439036 important that you adhere to these instructions. Do not take more than your physician tells you to take. Cetislim capsules are offered in 60 mg strength. The dose is to take one capsule with each meal. Don’t skip meals and don’t take more of the medication than prescribed. Taking cetilisat with food can help to block the fat from what you eat from being absorbed into the body. Make sure you work with your doctor to ensure the right foods are eaten and you are taking this medication as you should. 4. Orlistat Dosage Orlistat powder was oral used as a capsule and a nonprescription capsule.The recommended dosage of Orlistat powder is one 120-mg (a capsule )one time, three times a day . Take orlistat powder during a meal or up to 1 hour after a meal. If a meal is missed or does not have fat, you may skip your dose. Follow the directions on your prescription label or the package label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take orlistat powder exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor or stated on the package. 4

5. Email: aas11@aasraw.com Whatsapp:+8618928439036 ★ ★ When You Take Raw Orlistat Powder: • divide the amount of daily fat, carbohydrates, and protein. • While you are taking weight loss orlistat, you should avoid foods that with more than 30% fat. • When eating meat, poultry (chicken) or fish, eat only 2 or 3 ounces (55 or 85 grams) for a serving, lean cuts of meat is ok. with more grains, fruits, and vegetables. Replace whole-milk products with nonfat or 1% milk and reduced- or low-fat dairy items. • Take a daily multivitamin that contains vitamins A, D, E, K, and beta-carotene Orlistat blocks your body's absorption of some fat-soluble vitamins and beta carotene. Therefore, when you use orlistat you should take a daily multivitamin that contains vitamins A, D, E, K, and beta-carotene. Read the label to find a multivitamin product that contains these vitamins. Take the multivitamin once a day, 2 hours before or 2 hours after taking orlistat, or take the multivitamin at bedtime. Click here: take orlistat,orlistat powder,buy orlistat, Orlistat side effect. ★ ★ After You Use It: Keep this medication in the container, tightly closed, Where out of reach of children. The expiry date of Orlistat usually are 2 years,you'd better store it at room temperature and away from excess heat, moisture (not in the bathroom), and light. The best way to dispose of your medication is through a medicine take-back program instead of flushing this medication down the toilet. ★ ★ Cycle Of Orlistat Powder 5

6. Email: aas11@aasraw.com Whatsapp:+8618928439036 Orlistat powder should be taken every day to be effective. Weight loss normally starts within 2 weeks and continues for 6 to 12 months on Orlistat fat loss. Orlistat powder will then help you to maintain this new lower weight and help to prevent weight being regained. The improvement in risk factors (such as reduction in high blood pressure, normalising blood sugar levels and lowering cholesterol levels) is usually observed within 1 month of starting therapy and has been maintained during the course of Orlistat treatment. 5. Cetilistat powder review Cetilistat powder is an inhibitor of pancreatic lipase, an enzyme that breaks down triglycerides in the intestine. Without this enzyme, triglycerides from the diet are prevented from being hydrolyzed into absorbable free fatty acids and are left to be excreted undigested. This drug, while similar to the currently FDA-approved drug orlistat powder, may have a more tolerable side-effect profile due to a different molecular structure. A phase 2 trial studied 612 obese, diabetic subjects with a BMI of 28 to 45 kg/m2 over a 12-week treatment period. Cetilistat 80 and 120 mg promoted significant weight loss compared with placebo (3.85 kg and 4.32 kg vs. 2.86 kg, respectively). Cetilistat-induced weight loss was similar to the weight loss achieved with orlistat powder (3.78 6

7. Email: aas11@aasraw.com Whatsapp:+8618928439036 kg). Cetilistat powder was well tolerated and showed fewer discontinuations due to adverse events than in the placebo and orlistat powder groups. Given that discontinuation in the orlistat powder group was significantly worse than in the 120 mg cetilistat and placebo groups, and was entirely due to gastrointestinal adverse events, cetilistat may become a preferred lipase inhibitor for achieving weight loss . Phase 3 trials of cetilistat powder are currently in progress in Japan. 6. Orlistat powder review When considering Orlistat powder there needs to be a careful consideration of possible side effects, clinical studies, and what people have to say about it. The FDA has sent a warning letter of possible serious kidney damage caused by Orlistat powder. There’s also many possible side effects, and many customers did mention they experienced effects. Also, clinical studies have shown it to be only effective for up to 6 pounds of weight loss in one year. This is nowhere the amount needed for there to be noticeable results. Still, many custoemrs failed to see any change in weight. There’s the 2016 best diet pill called Sletrokor which was rated as this way due to its all natural ingredients, potent weight loss, and customer approval rate. Many users mention it is safe and effective for helping with weight loss. It’s also shown to be good for appetite reduction, increasing metabolism, helping improve mood, and several other benefits. You can find out about this diet pill by clicking here. Sletrokor is also backed by a full 30 day money back guarantee. If for any reason you want to schedule a return, you can do so with no questions asked. Click here to find out more about Sletrokor. 7

8. Email: aas11@aasraw.com Whatsapp:+8618928439036 7. Cetilistat side effects The most commonly reported cetilistat side effects are oily stools, diarrhea, fecal incontinence, frequent bowel movements, and flatulence. In particular,in obese diabetic patients the levels of glycosylated hemoglobin (HbA1c) were also significatively reduced. Cetilistat powder showed mild to moderate adverse events, predominantly of gastrointestinal nature (steatorrhea), with an incidence lower than orlistat powder. 8. Orlistat side effects Many of the side effects associated with Orlistat powder are digestive symptoms, probably due to the non-absorption of fats. The most commonly occurring side effect is a change in bowel moments, which often occurs during the first couple of weeks of taking the supplement. Side effects may go away, but it is possible for it to continue for a person’s entire duration on the medication. Possible Side Effects • Reduced absorption of fat-soluble vitamins like A, D, E, and K • Severe lower back pain • Vomiting • Kidney issues • Ankle swelling • Shortness of breath • Fatigue • Oily, smelly stools • Increased bowel movements, loose stools, inability to control bowels 8

9. Email: aas11@aasraw.com Whatsapp:+8618928439036 Frequency of Side Effects The FDA has also published information as to the frequency of certain side effects. In the first year of taking prescription strength Orlistat powder: • 26.6% of users reported oily spotting. • 23.9% reported gas with discharge. • 22.1% experienced urgent bowel movements. • 20% had fatty or oily stools. • 10.8% had an increased number of bowel movements. • 7.7% suffered fecal incontinence. For 8.8% of Orlistat users, side effects were serious enough for them to discontinue use. In addition to mild or moderate Orlistat side effects, more severe side effects may occur. Users who experience any more severe side effects should discontinue use and contact their doctor. 9

10. Email: aas11@aasraw.com Whatsapp:+8618928439036 9. Cetilistat powder Better Tolerated Than Orlistat powder BUDAPEST, HUNGARY -- April 24, 2007 -- Cetilistat powder, a novel gastrointestinal lipase inhibitor, appears to be as effective in the management of obesity and its comorbidities as another lipase inhibitor, orlistat powder, while demonstrating better tolerability, according to two phase 2 randomised, double-blind, placebo-controlled, 12-week studies. "Lipase inhibition has proven efficacy in obese patients and in obese patients with diabetes," said Peter Kopelman, dean, faculty of health, University of East Anglia, Norwich, United Kingdom, who presented the two studies on behalf of the Cetilistat powder European Study Group here at the 15th European Congress on Obesity (ECO). The first study investigated the use of cetilistat powder in 372 obese patients with a body mass index (BMI) > 30, in centres throughout Europe. All patients received intensive dietetic counselling throughout the study and consumed a prescribed diet that was calculated to be approximately 500 kcals below their weight-maintaining diet. In addition, patients were given 60, 120, or 240 mg of cetilistat powder, or placebo, at mealtimes, three times daily. Significant weight loss was achieved in all treatment groups at 12 weeks, with a 3.5-kg reduction in weight achieved with 120 mg cetilistat powder three times daily versus placebo (P <.05). "Cetilistat powder was effective in inducing weight loss in 12 weeks of study," Dr. Kopelman said in a presentation on April 23rd. "In addition, there were significant reductions in waist circumference." In the second study presented by Dr. Kopelman, the researchers enrolled 612 obese subjects with type 2 diabetes, who were taking metformin. Many of the patients were also on statins, and about a third were also taking antihypertensive medication. 10

11. Email: aas11@aasraw.com Whatsapp:+8618928439036 As in the previous study, patients received a hypocaloric diet and one of three different doses of cetilistat powder (40, 80, or 120 mg), or placebo. In addition, a fourth study group was randomised to 120 mg of orlistat daily. Dr. Kopelman said that significant weight reductions were achieved in all treatment groups, with approximately 35% of subjects on the highest cetilistat powder dose achieving a weight loss of about 5% of their initial body weight or more. In addition, there were statistically significant reductions in glycosilated haemoglobin (HbA1c) over 12 weeks. Although the efficacy data were comparable between cetilistat powder and orlistat powder, considerable differences emerged between these two drugs regarding their tolerability profiles, according to Dr. Kopelman. powder 3 times Overall, patients treated with orlistat powder had nearly twice as many serious adverse events -- primarily gastrointestinal discontinuation than in the cetilistat powder group. The rate of severe adverse events leading to discontinuation was comparable between the placebo group and those receiving cetilistat powder. On the basis of these results, Dr. Kopelman concluded that cetilistat powder has a favourable tolerability profile, and it is safe and efficacious in the management of obesity and its comorbidities. -- leading to treatment 11

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