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ALTERATIONS OF THE CENTRAL NERVOUS SYSTEM

ALTERATIONS OF THE CENTRAL NERVOUS SYSTEM. EXEMPLAR OF MULTIPLE SCLEROSIS INTRODUCTION AND ASSESSMENT. Multiple Sclerosis. Definition -chronic, autoimmune neurologic disease -affects myelin sheath -etiology: unknown. Four Classifications. Relapsing-remitting (RRMS) most common

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ALTERATIONS OF THE CENTRAL NERVOUS SYSTEM

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  1. ALTERATIONS OF THE CENTRAL NERVOUS SYSTEM EXEMPLAR OF MULTIPLE SCLEROSIS INTRODUCTION AND ASSESSMENT

  2. Multiple Sclerosis • Definition -chronic, autoimmune neurologic disease -affects myelin sheath -etiology: unknown

  3. Four Classifications • Relapsing-remitting (RRMS) most common -attacks followed by recovery • Primary Progressive (PPMS) -gradual and steady neuro deterioration • Secondary Progressive (SPMS) -starts as relapse-remitting then becomes steadily progressive • Progressive-relapsing (PRMS) -frequent relapses with only partial recovery

  4. POPULATIONS AT RISKPERSONAL RISK FACTORS • Age: 20 to 40/50 yrs. Old • Gender: F>M • Race: Caucasian RISK FACTORS • First degree relative • Genetic susceptibility • Environment- colder climate • Smoking • Exposure to viruses

  5. assessment • Patient History • Signs and Symptoms • -Mobility fatigue, balance, weakness, spasticity • -Sensory numbness, temperature sensitivity, vision • -Cognitive/Emotional impaired judgment, reasoning • -Bowel and Bladder Dysfunction • -Sexual Dysfunction

  6. http://www.5min.com/Video/Learning-to-Cope-with-Multiple-Sclerosis-264563718http://www.5min.com/Video/Learning-to-Cope-with-Multiple-Sclerosis-264563718

  7. Diagnostic tools • MRI of brain and spine • CSF: during an attack protein ,slight WBC • CSF electrophoresis: myelin basic protein • IgG (oligoclonal) bands present • Various evoked potential tests • McDonald Criteria (4 criteria)

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