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Workshop: Framework Synthesis, Meta-Ethnography and Realist Synthesis

Workshop: Framework Synthesis, Meta-Ethnography and Realist Synthesis . Shared Topic: Adherence to Antiretroviral therapy (ART) for HIV in Zambia.

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Workshop: Framework Synthesis, Meta-Ethnography and Realist Synthesis

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  1. Workshop: Framework Synthesis, Meta-Ethnography and Realist Synthesis

  2. Shared Topic: Adherence to Antiretroviral therapy (ART) for HIV in Zambia • BACKGROUND: Antiretroviral therapy (ART) has significantly improved morbidity and mortality of individuals infected with HIV. However, lack of adherence to highly active antiretroviral therapy (HAART) remains a key challenge to successful management of patients with HIV/AIDS. Adherence rates lower than 95% are associated with development of viral resistance to antiretroviral medications. • ‘Efforts to sustain adherence in Africa and elsewhere remain important goals to optimize outcomes for individuals and global HIV treatment.’ (Mills, Nachega, Buchan, Orbinski, Attaran, Singh et al., 2006).

  3. Shared Topic: Adherence to Antiretroviral therapy (ART) for HIV in Zambia • Different Emphases • Barriers and Facilitators to ART (Best Fit Framework Synthesis) • Theory Explaining Adherence to ART (Meta-Ethnography) • Under what Contexts and For Whom is Adherence to ART Effective in Zambia (Realist Synthesis)

  4. Reading and Data Extraction

  5. Data extraction • What is it? • An attempt to reduce a mass of material (your included papers) to a much smaller body of text and numbers, amenable to analysis and the interpretation of findings

  6. Data extraction form • Location • Setting • Sample (n) • Age • Gender • Ethnicity • Socio-economic status • Intervention (if any) • Quality assessment criteria • Results? • Further citations • See Handouts 1-3 • Format?????

  7. What results do you extract? What is your question? Keep the question in mind as you read: Are the data relevant to this question? Is the question answered by the data?

  8. Data Extraction

  9. Quality Assessment Andrew Booth, Reader in Evidence Based Information Practice, Co-Convenor – Cochrane Collaboration Qualitative Methods Group

  10. Before You Begin… • Consider how you will use judgements of quality (cp. 50% of published Cochrane Quantitative Reviews performed quality appraisal but did not make it clear how judgements were used!) • To exclude or to moderate? • Will chosen instrument militate against certain types of research? • Quality of reporting or quality of study?

  11. Variability in Practice - 1 21 papers did not describe appraisal of candidate studies 6 explicitly mentioned not conducting formal appraisal of studies 5 papers did a critical appraisal, but did not use a formal checklist 7 described modifying existing instruments 1 used an existing instrument without modification Dixon-Woods, Booth & Sutton (2007)

  12. Variability in Current Practice - 1 23 papers did not describe critical appraisal 5 papers explicitly pleaded against quality assessment of papers or provided valid reason for not conducting quality appraisal. Criteria used varied between detailed descriptions of relevant items in existing or modified checklists to a set of broad criteria evaluating, for example, rich description of data, credibility or relevance of the original study. Hannesand Macaitis(2012)

  13. Variability in Current Practice - 2 One team used overall judgement (Smith et al., 2005). Five opted for self-developed assessment instrument Three used previously developed checklists to create own. Two mentioned critical appraisal, but did not specify tool. Most used existing instruments/frameworks. 24 different assessment tools identified: Critical Appraisal Skills Programme (CASP) (n = 18) Mays and Pope criteria (n = 6) Popaycriteria (n = 6) Joanna Briggs Institute (n = 4). Hannesand Macaitis(2012)

  14. Appraising research quality 1. Epistemological criteria: Judgement of ‘trustworthiness’ requires criteria tailored to different research ‘paradigms’. 2. Theoretical Criteria: Explicit theoretical framework shaping the design of the study and informing claims for generalisability 3. Prima facie ‘Technical’ criteria: Used to assess ‘quality’ common to all research traditions e.g.: Sufficient explanation of background; Method appropriate to question; Succinct statement of objectives/research questions; Full description of methods include approach to analysis; Clear presentation of findings including justification for interpretation of data etc. Noyes J (2005)

  15. Two dimensional approach to appraising qualitative research (Noyes, 2005)

  16. Available Tools - 1 • CASP – 10 questions to help you make sense of qualitative research http://www.casp-uk.net/wp-content/uploads/2011/11/CASP_Qualitative_Appraisal_Checklist_14oct10.pdf • Joanna Briggs Institute - Critical Appraisal Checklist for Interpretive & Critical Research http://www.jbiconnect.org/agedcare/downloads/QARI_crit_apprais.pdf • National Centre for Social Research. Quality in Qualitative Evaluation: A Framework for Assessing Research Evidence. London: National Centre for Social Research/UK Cabinet Office, 2003 http://www.civilservice.gov.uk/wp-content/uploads/2011/09/a_quality_framework_tcm6-38740.pdf

  17. Available Tools - 2 • Dixon-Woods M, Shaw RL, Agarwal S & Smith JA (2004) The problem of appraising qualitative research. Quality & Safety in Health Care, 13, 223-5. • Hannes K, Lockwood C, Pearson A (2010). A comparative analysis of three online appraisal instruments' ability to assess validity in qualitative research. Qualitative Health Research. 20(12):1736-43. • Popay J, Rogers A & Williams G (1998) Rationale & standards for the systematic review of qualitative literature in health services research. Qualitative Health Research, 8, 341-51. • Seale C & Silverman D (1997) Ensuring rigour in qualitative research. European Journal of Public Health, 7, 379-84.

  18. CASP – Technical/Procedural Tool

  19. JBI – Theoretical Tool

  20. Key Issue • How are you going to use the quality assessment? • From quantitative assessment we know authors frequently say they do it – but they don’t incorporate it into results • Is it technical proceduralism gone mad? • Or can we use the assessments to improve our synthesis and subsequent interpretation?

  21. Quality Assessment

  22. Data Synthesis

  23. What is Data Synthesis? • Process of moving from focus on single studies (cp. Data Extraction and Quality Assessment) to focus on cross-study analysis • Requires identification of patterns across data, including contradictory findings and data that does not fit • Iterative and requires ongoing refinement • Acts as prelude to Analysis which seeks to explain patterns, contradictions and differences

  24. Thematic synthesis; Critical Interpretive Synthesis; Meta-ethnography Only include “good” qualitative studies (?) Constant comparison; iterative; interpretations generated from the data by reviewers Create a theory Inductive (theory-generating) Examples: Thomas J, Harden A. Methods for the thematic synthesis of qualitative research in systematic reviews. BMC Medical Research Methodology2008; 8. Campbell R et al. Evaluating meta-ethnography: a synthesis of qualitative research on lay experiences of diabetes and diabetes care. Social Science & Medicine 2003; 65:671-684. Methods of qualitativeevidencesynthesis

  25. Framework synthesis: Only include “good” qualitative studies (?) Map data from included studies onto an existing framework to test the framework/theory (a role for theory) Build a conceptual model or framework Deductive (theory-testing) Examples: Oliver S et al: A multidimensional conceptual framework for analysing public involvement in health services research. Health Expectations 2008, 11:72-84. Brunton G, Oliver S, Oliver K, Lorenc T. A Synthesis of Research Addressing Children’s, Young People’s and Parents’ Views of Walking and Cycling for Transport London. London, EPPI-Centre, Social Science Research Unit, Institute of Education, University of London; 2006. Methods of qualitative evidence synthesis

  26. “Best-fit” framework synthesis Identify relevant pre-existing conceptual models or frameworks Identify and extract all relevant qualitative studies satisfying review’s inclusion criteria Code data from included studies against framework Use secondary thematic analysis/synthesis to generate completely new themes to supplement the framework’s themes Create new framework and conceptual model or theory Deductive and Inductive Framework and Thematic synthesis Carroll C, Booth A, Cooper K. A worked example of “best-fit” framework synthesis: A systematic review of views concerning the taking of potential chemopreventive agents, BMC Medical Research Methodology2011; 11: 29 Methods of qualitative evidence synthesis

  27. Realist Synthesis (Also The Matrix Method); Examine Provisional Explanatory Model Extract Data against Provisional Explanatory Model Assess for Rigour and Relevance Develop Propositional Statements Consider the Strength of Evidence for Each Propositional Statement Refine and Revise Provisional Explanatory Model Merten, S., Kenter, E., McKenzie, O., Musheke, M., Ntalasha, H., & Martin‐Hilber, A. (2010). Patient‐reported barriers and drivers of adherence to antiretrovirals in sub‐Saharan Africa: a meta‐ethnography. Tropical Medicine & International Health, 15(s1), 16-33. [Candy B, King M, Jones L, Oliver S. Using qualitative synthesis to explore heterogeneity of complex interventions. BMC Med Res Methodol. 2011 Aug 26;11:124. doi: 10.1186/1471-2288-11-124]. Integration of qualitative and quantitativeevidence

  28. Data Synthesis

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