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ALZHEIMER’S and DEMENTIA

ALZHEIMER’S and DEMENTIA. What are the odds of growing old and NO LONGER having a functional mind ? We all expect to lose some of our physical capabilities ! ! How do you feel about losing your mind ?? Without a solution to Alzheimer’s you can bet your mind will be gone in your old age.

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ALZHEIMER’S and DEMENTIA

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  1. ALZHEIMER’S and DEMENTIA What are the odds of growing old and NO LONGER having a functional mind ? We all expect to lose some of our physical capabilities ! ! How do you feel about losing your mind ?? Without a solution to Alzheimer’s you can bet your mind will be gone in your old age. If true, why would you want to extend your lifespan and grow old; - healthy or otherwise ! Metavo has a nutritional solution; and we are working on a pharmaceutical solution.

  2. Which animal represents your health status ? Can innovative treatment help your brain ? Administration of a single Nutrient / Supplement to dwarf mice brothers affects physical appearance and health And produces a 40% life-extension in one of them.

  3. What are the odds of getting Alzheimer’s after you pass the biblical prediction of three score and ten [70]. Diagnosis By Autopsy Get 30% level at 90 But only after you’re dead. 30 % --> New England Journal of Medicine. 2003. V340, p356

  4. Worse case diagnosis of Alzheimer’s It is a dementia assessment. 50%--> When diagnosed as having Alzheimer’s disease by symptoms means -gradual onset, -progressive deterioration dementia -lack of any other specific causes Kungsholmen Project, Finland Qiu, Kivipelto,-Torres, Winblad and Fratiglioni J. Neurol. Neurosurg. Psychiatry 2004;75;828-833

  5. What are our chances of having dementia or Alzheimer’s by 65? 10%

  6. What are our chances of having dementia or Alzheimer’s by 85? Data -Alzheimer’s Assoc. 50%

  7. Forgetfulness Confusion Personality Change Inability to Communicate Total Dependence on Care Giver Death Progression of Alzheimer’s Disease Mental Capacity Time

  8. Performance Standard Vs AGE You expected that as you reach old age -your physical powers will decline. • Performance standards set by world class athletes • D H Moore Nature 253: 264-5 1975 • P S Riegel American Scientist 69: 285-290 1981

  9. And cross-section of physiological markers with age -Shows that problems are parallel ! Nerve Conduction Velocity Metabolic Rate Cardiac Index Vital Capacity Renal Flow Breathing Capacity You whole body declines -all systems go to H…...

  10. Aging Atrophy Young Old Young brain Old Brain If your physiological capabilities, skin, muscles etc change You know your brain does too.

  11. Alzheimer’s Treatments • Present FDA approved drugs - treat only symptoms NOT the cause. • Prescriptions focus on RELIEF of these conditions • Depression • Dementia • Cognition and temporary memory improvement • FDA approved Treatments • DO NOT preventdisease progression

  12. Target Markets • Neurodegenerative Diseases in US • Alzheimer’s disease – 5.8 Million • Parkinson’s disease – 1 M • Lou Gehrig’s -ALS – 35 K • Oxidative Diseases of Aging • Macular degeneration – 10 Million • Atherosclerosis – 13 M • Osteoarthritis - >20 M

  13. Alzheimer’s Disease • The Brain is Highly Susceptible to Oxidative Damage • Brain consumes 20% of the oxygen the body uses • High Concentration of Fatty Acids - easily damaged • Concentrates High Levels of Metals • Contains Low Levels of Antioxidants • Long-life Cells with Little Turnover • US $2.6 B sales for therapeutics in 2003 • Growing 19% annually

  14. The Aging Population 2000 2050 -----85----- -----65----- Expected US population expansion 2050 Dramatic at older ages

  15. If aging and Alzheimer’s are inevitable Do you wish a cure! OR do you accept growing old ?? SOLUTIONS ARE IN PROGRESS !! --->

  16. Nutritional Supplement Turmeric; the spice contains Curcumin-the agent Curcumin works against Alzheimer’s models in cell culture and animals !! See Feb 2007 Scientific American Clinical trial are underway. However, it will NOT be promoted because ‘Big Pharma’ cannot make enough money [$$] from a nutrient.

  17. An old World dye used in the 1900’s for malaria treatment; Methylene Blue Methylene Blue acts to destroy the Alzheimer’s causes- Tau aggregates and intra-cellular ß-amyloid toxic peptides.

  18. An old World dye - legally a drug was a 1900’s malaria treatment; Methylene Blue Methylene Blue has been shown to work to destroy Both the Alzheimer’s toxic agents; Tau protein aggregates and intra-cellular ß-amyloid toxic peptides. The agents are responsible for the death of brain cells and why dementia occurs in the aged. Methylene blue, a dye, has been used medically since the early 1900’s [malaria] and is still used in urinary conditions. The good news is that, at low doses [>1/10th], it interferes with the formation of tau and ß-amaloid aggregates that cause the neuro-pathologies of Alzheimer’s and probably other age-related diseases.

  19. SCYLLO-INOSITOL McLaurin et al. Recently Reported in Nature Medicine that oral administration of scyllo-inositol, an isomer of the ubiquitous sugar, inositol, both increases the lifespan of mice that are transgenic models of Alzheimer’s disease and also phenotypically reduces the affected areas of the mouse brain.

  20. What are the solutions to Alzheimer’s and Neurological pathologies. ??? The common nutrients, curcumin, and the inositol sugar isomer, scyllo-inositol, plus the old world dye, methylene blue are reported to be effective to treat Alzheimer’s disease under experimental conditions. All three are presently being tested in various clinical trials throughout the world. Although the results indicate that these compounds reverse the pathological conditions of Alzheimer’s disease they are given at high doses but…. ’big’ pharma cannot make money. The pharmaceutical industry demands molecules that are effective at much lower dose levels. This requires the invention derivatives that function effectively. Metavo’s molecules have that potential.!

  21. Alzheimer’s Disease: Cause & Effect The Solution ! To Intervene in the Beta-amyloid (Aβ)Cascade and Tau protein aggregation. Statistics show that 50% of persons 85 years and older will lose their minds to Alzheimer’s and Dementia.

  22. Alzheimer’s is an Age-related condition of Brain/NerveCells Statistics show that 50% of persons 85 years and older will lose their minds to Alzheimer’s and Dementia. Prevention and Therapy Nutritional therapy & Anti-oxidants Acetyl Carnitine- Alpha Lipoic Acid Omega-3-fatty acids Phosphotydl-choline Patented Nitrones Polyphenols and bioflavonoids Specific experimental therapeutics Methylene Blue Nutraceuticals - Curcumin - Scyllo-inositol

  23. Metavo has invented analogs and derivatives of Curcumin and Bio-flavonoid that alleviate the cellular pathologies seen in Alzheimer’s animal models. The result is improved memory and cognitive capabilities The molecules are :-- Pharmaceutical -not nutrients Patented Effective at lower doses Low toxicity Neuro-protective protect your brain. Alzheimer’s and Dementia are ‘normal’ age-related conditions of Brain/Neural Cells

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