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SAPPHIRE: 3-Year Results

SAPPHIRE: 3-Year Results. Death, stroke, or MI at 30 days plus death or ipsilateral stroke between 31 days to 3 years: 24.6% for stent and 26.9% for CEA (p = 0.71) Mortality to 3 years: 20.0% versus 24.2% (p = 0.68), respectively Stroke to 3 years: 10.1% versus 10.7% (p = 0.77), respectively .

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SAPPHIRE: 3-Year Results

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  1. SAPPHIRE: 3-Year Results Death, stroke, or MI at 30 days plus death or ipsilateral stroke between 31 days to 3 years: 24.6% for stent and 26.9% for CEA (p = 0.71) Mortality to 3 years: 20.0% versus 24.2% (p = 0.68), respectively Stroke to 3 years: 10.1% versus 10.7% (p = 0.77), respectively Trial design:Patients with severe internal carotid artery stenosis and high surgical risk were randomized to carotid stenting with embolic protection (n = 167) or carotid endarterectomy (CEA) (n = 167) and followed for 3 years. Results (p = 0.71) (p = 0.68) 24.6 26.9 20.0 24.2 % Conclusions • Carotid stenting with embolic protection produces similar long-term results to CEA in high surgical risk patients • This therapy results in similar cumulative mortality and stroke at 3 years Death, MI, stroke to 30 days plus death or stroke to 3 years Mortality Carotid stenting Carotid endarterectomy Gurm HS, et al. N Engl J Med 2008;358:1572-79

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