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DNA origami

English for Chemists. DNA origami. Dresden, 10 th December 2013. DNA as genetic material. Design new structures with DNA ?!. DNA nanotechnology. DNA nanotechnology or DNA nanoengineering: using DNA to design different structures

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DNA origami

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  1. English for Chemists DNA origami Dresden, 10th December 2013

  2. DNA as genetic material DNA origami

  3. Design new structures with DNA ?! DNA origami

  4. DNA nanotechnology • DNA nanotechnology or DNA nanoengineering: using DNA to design different structures • only using the structure material of DNA, not the genetic informations • goal: to create a number of more complex (two-dimensional or three-dimensional) nanostructures with a defined structure DNA origami

  5. Chemical structure ofDNA • two polymer chains (double helix) monomers: callednucleotides • backbone: ismade a phosphateand a deoxyribose (esterbonds) • fournucleobases: Adenine, Thymine, Guanine, Cytosine DNA origami

  6. Watson–Crick basepairing • specificity of Watson–Crick base pairing: • only hydrogen interations between: • Adenine Thymine (two hydrogen bonds) • Guanine Cytosine (three hydrogen bonds) DNA origami

  7. DNA origami • ssDNA (singlestranded DNA): plasmidof a bacteriophage, e.g. λ-DNA ‘single-strandedscaffold’ (Einzelstrang-Gerüst) • shortoligonucleotides ‘staple strands’ • staple and scaffold strands self-assemble in a single step (reason: Watson-Crick base pairing), many of these interactions forms structures DNA origami

  8. DNA origami

  9. DNA origami

  10. Using DNA origamifor … • as a substrate for nanoelectroniccircuitry (Schaltkreise) • transport drugs in a DNA origami box • … DNA origami

  11. Thank you for your attention !I will be happy to answer your questions now. DNA origami

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