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Principals of Animal Diseases Internal metabolik diseases. Di siapkan oleh Prof . Dr.Pratiwi Ts. Deskripsi materi.
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Principals of Animal DiseasesInternal metabolik diseases Di siapkanoleh Prof . Dr.Pratiwi Ts poultry metabolik diseases-pts-2
Deskripsimateri Membahas gejala, kausaserta pathogenesis danpatofisiologiberbagaijenispenyakitinterna yang bersifatsistemik, diakibatkanolehgangguan metabolism, hormonal, faktorketurunanataugenetik, sertaketepatanpenegakantindakandiagnostiksehinggadapatmelakukanterapi yang tepatsesuaidenganpenyebabnyapadaberbagaispesieshewan. peny metabolik pts 2012
Tujuan Diakhir kuliah mahasiswa diharapkan dapat memahami dan menjelaskan jenis penyakit interna disebabkan gangguan metabolisme dan genetik meliputi gejala dan penyebab serta dapat melakukan diskusi untuk menentukan diagnosa, tindakan prevensi dan memilih tindakan kuratif yang tepat. peny metabolik pts 2012
APA YANG DIMAKSUD DENGAN METABOLIC DISEASES peny metabolik pts 2012
What is a metabolic disease? “Inborn errors of metabolism” inborn error : an inherited (i.e. genetic) disorder metabolism : chemical or physical changes undergone by substances in a biological system “any disease originating in our chemical individuality” In toxication peny metabolik pts 2012
Energy Balance ENERGY BALANCE EBAL = Feed Intake – (Maintenance (BW0.75) + Milk Production (yield and composition)) Especially fat! OUTPUT INPUT OUTPUT
When the rate of “input” of dietary nutrientsis out of balance with the rate of “output” ofproduction (lambs, kids, milk) Metabolic diseases occur when homeostatic and fuel mechanisms fail peny metabolik pts 2012
Caused of metabolic disease? • Small molecule disease • Carbohydrate • Protein • Lipid • Nucleic Acids • Toxin • Organelle disease • Lysosomes • Mitochondria • Peroxisomes • Cytoplasm peny metabolik pts 2012
Noninfectious Disease Not contagious Genetic diseases Caused by defects in the genes Problem or disease can be passed from parent to offspring
Genetic Diseases Cannot be spread through contact with other animals Control of genetic diseases, using good selection practices Avoid breeding animals that are known to have genetic defects in their line
Nutritional Diseases Milk fever in dairy cattle Cows lie down and are unable to stand Insufficient amount of Ca in the bloodstream
Poisoning Moldy feed can contain toxins Aflatoxins and ergot – fungi that grow on grains Grazing on poisonous plants
How do you recognize a metabolic disorder ?? • SIMPLE LABORATORY TESTS, CLINICAL EXAMINATION • Glucose, Electrolytes, Gas, Ketones, BUN (blood urea nitrogen), Creatinine, Kalsium • Lactate, Ammonia, Bilirubin, LFT • Amino acids, Organic acids, Reducing subst peny metabolik pts 2012
Health is determined by interaction of interrelated variables 1. Genetic or biological determinants, 2. Behavior (diet and lifestyle habits), 3. Pre-and postnatal environments (physical, biologic, economic, and social), 4. The health care system peny metabolik pts 2012
1-Stage of pre-pathogenesis (pre disease) (susceptibility) = well: The disease has NOT developed ( animal is not yet involved) but animal is very much exposed to risk factors which increase the likelihood that the disease will develop. peny metabolik pts 2012
2-Stage of pathogenesis: • starts with entry of the agent Pre-symptomatic stage (latent disease): No signs or symptoms (incubation period) • start of pathologic changes Clinical disease stage (symptomatic disease): peny metabolik pts 2012
TREATMENT Antibiotics Useful in controlling bacteria – not viruses Are drugs that originate from living sources Usually those living sources are molds and fungi BUKAN UNTUK TERAPI PENYAKIT METABOLIK TETAPI SIDE EFFECT (KONTAMINASI SEKUNDER)
Non-infectious health problems differ from infectious Examples of non-infectious problems: Genetic defects Nutritional disorders Poisoning Metabolic disorders (ketosis, diabetes) peny metabolik pts 2012
Outcome (end results) of the disease process: • Recovery (cure). • Chronicity. • Disability (any limitations of person's activities -mental or physical- as a result of acute or chronic condition). • Death. peny metabolik pts 2012
PENYEBAB LAIN ? OBESITAS BODY COMPOSITION SBORE peny metabolik pts 2012
BCS and Increased Health Risk Metabolic problems can set the stage for consequences of other nutritional-stress complications, including infections such as mastitis. • Excess Body Condition • Fat Cow Syndrome • Ketosis • Displaced Abomasum • Milk Fever • Metritis • Mastitis • Lameness • Limited Dry Matter Intake • Thin Body Condition • Lameness peny metabolik pts 2012
JENIS-JENIS PENYAKIT Milk Fever = hypocalcemia Pregnancy Toxaemia / Ketosis / Fatty Liver Disease Ketosis(Acetonemia, acetonuria, ketonemia, ketonuria Hepatic LipidosisFatty liver disease, fat cow syndrome, pregnancy toxemia (small ruminants) peny metabolik pts 2012
JENIS-JENIS PENYAKIT Lactational Ketosis / Fatty Liver Disease Nervous ketosis Hypomagnesemia (Grass Tetany, Lactation Tetany, Milk Tetany) Lactic Acidosis (Grain Overload) Zinc Deficiency peny metabolik pts 2012
KULIAH KE 2 peny metabolik pts 2012
PeriparturientHypocalcemia(Milk Fever) peny metabolik pts 2012
Milk Fever = hypocalcemia (low blood calcium) • When: within 2 days of calving on 3rd or later lactation • Why: rapid synthesis of milk draining calcium from blood • D: no fever, cow staggering or down, off feed, glazed eyes peny metabolik pts 2012
Hypocalcemia (1) Hypocalcemia is a disease commonly seen in dairy cattle on or immediately following calving. Small ruminants can experience hypocalcemia during late pregnancy associated with rapid calcium loss to the developing fetus(es) for bone mineralization. Other species can experience hypocalcemia at or near the time of peak lactation (lactationaleclampsia). peny metabolik pts 2012
Hypocalcemia (2) Hypocalcemia during late pregnancy is a result of insufficient dietary calcium to meet fetal needs. Insufficient calcium intake during late pregnancy or early lactation will require the body to mobilize calcium from bones to meet the need. If the hormonal mechanisms are not properly prepared, mobilization will be delayed and low blood calcium concentration will result peny metabolik pts 2012
Pregnancy Toxaemia peny metabolik pts 2012
Pregnancy Toxaemia / Ketosis / Fatty Liver Disease Pregnancy toxemia (pregnancy ketosis or twin lamb/kid disease) is a metabolic disease of goats and sheep commonly occurring in the last six weeks of gestation, especially in those dams with multiple fetuses. Negative energy balance with associated mobilization of fatty acids (NEFA) from adipose stores is the underlying problem. peny metabolik pts 2012
Factors inducing a reduction in feed intake (pregnancy, poor quality forages, feeding management) or increasing energy requirement (rapid fetal growth, lactation, environmental conditions) contribute to the duration and magnitude of negative energy balance and predisposition to aberrant metabolism leading to subclinical or clinical disease. peny metabolik pts 2012
Faktoreksternal Addition of external stressors such as severe weather, sudden changes in feed, other disease or transportation further accentuate negative energy balance. Mortality rate is high in affected animals when liver function is compromised as a result of fatty infiltration. peny metabolik pts 2012
Ketosis peny metabolik pts 2012
Ketosis(Acetonemia, acetonuria, ketonemia, ketonuria) Definition of ketosis: Abnormally elevated concetrations of the ketone bodies acetoacetic acid, acetone, and Betahydroxybutyrate, in body tissues and fluids peny metabolik pts 2012
Ketosis Occurrence: • Occurs 2 to 4 weeks after calving (peak incidence is about 3 week) • Affect most high producing cows (sub-clinically) in early lactation • “Typical” ketone (acetone) smell in the breath; Lack of appetite Decreased rumen mobility and production of “dry feces” Loss of weight, gaunt appearance, and dullness Symptoms:
Ketosis Occurrence: • Two changes in the blood related to liver functions • Drop in blood glucose (<50 mg/dl) • Rise in -hydroxy butyrate (>14.4 mg/dl) • Presence of ketones in urine (“Ketostick”): • -hydroxy butyrate; Acetone; Aceto-acetic acid. Detection:
Fatty liver disease peny metabolik pts 2012