1 / 10

PIDA-Mediated Oxidative C-O Bond Formation: Novel Synthesis of Oxazoles from N - Acyl Enamines

PIDA-Mediated Oxidative C-O Bond Formation: Novel Synthesis of Oxazoles from N - Acyl Enamines. Yunhui Zheng 2013.04.12. Introduction. 1.1 The structure of oxazole A class of five-member ring, heteroaromatic compounds.

lavi
Download Presentation

PIDA-Mediated Oxidative C-O Bond Formation: Novel Synthesis of Oxazoles from N - Acyl Enamines

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. PIDA-Mediated Oxidative C-O Bond Formation: Novel Synthesis of Oxazoles from N-AcylEnamines YunhuiZheng 2013.04.12

  2. Introduction • 1.1 The structure of oxazole • A class of five-member ring, heteroaromatic compounds. • Containing an oxygen atom and a nitrogen atom at the 1 and 3 positions of the ring. • The oxazole moiety is the key structure of a number of natural products.

  3. The oxazole is an important heterocycle and many natural products contain oxazole structure, such as disorazole A and hennoxazole A.

  4. Part A

  5. Part B

  6. Part C Unexpected Products

  7. Part D Application

  8. Conclusion • The hypervalent iodine reagent, Phenyliodinediacetate (PIDA) was successfully used in the synthesis of oxazoles. • A general methodology for the preparation of oxazoles was developed, which displayed excellent functional group compatibility in this reaction.

  9. Thank you!

More Related