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UK – Dutch collaboration

Planet 2 /MATISSE. UK – Dutch collaboration. Research staff. Enrico (E) Lopriore Neonatologist Leiden University Medical Center. Anske (JG ) van der Bom Professor of Clinical Epidemiology Leiden University Medical Center Sanquin Blood Supply. Karin (K) Fijnvandraat

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UK – Dutch collaboration

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  1. Planet 2 /MATISSE UK – Dutch collaboration

  2. Research staff Enrico (E) Lopriore Neonatologist Leiden University Medical Center Anske (JG) van der Bom Professor of Clinical Epidemiology Leiden University Medical Center Sanquin Blood Supply Karin (K) Fijnvandraat Pediatrichematologist AcademicMedical Center (Amsterdam) Sanquinbloodsupply

  3. History of Matisse trial • 2011 - 2012: Idea plus funding • 2013: PhD student + Planet-2 • Jan 2014: ethical approval • Feb 2014: start study in Amsterdam Managing Thrombocyte transfusions In a Special Subgroup: nEonates

  4. Study designs identical ? Inclusion criteria Transfusion thresholds Transfusion dose Outcome

  5. Participating centers Groningen Zwolle Amsterdam Leiden Rotterdam Veldhoven Nijmegen Maastricht

  6. Participating PI’s C. Hulzebos E. Lopriore A. Van Kaam E. D’Haens A. Kroon A. Donker … M. vd Hoeven W. de Boode

  7. Participating centers • 8 level II/III neonatal intensive care units • 4000 admission per year • 2000 < 34 weeks GA

  8. Planning • February 18 start in Amsterdam • February – september: start other centers • Datasharing • Expected inclusions: 65 / year Inclusions

  9. MONET: monitoring outcome in neonatal thrombocytopenia • Retro/prospective observational cohort • Goal: prediction model neonatal bleeding • Design phase, 1000-2000 inclusions

  10. Questions?

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