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AFIP 2007-2008

AFIP 2007-2008. Conference 15, Slide 3 Tissue from a dog. 6 yo female lab cross. History of atopy, managed with cyclosporine, prednisone, shampoo baths, and immunotherapy. Haired skin. Too cellular in dermis (too blue). What is the tissue?. What is abnormal?.

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AFIP 2007-2008

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  1. AFIP 2007-2008 Conference 15, Slide 3 Tissue from a dog.

  2. 6 yo female lab cross. • History of atopy, managed with cyclosporine, prednisone, shampoo baths, and immunotherapy.

  3. Haired skin. Too cellular in dermis (too blue). What is the tissue? What is abnormal?

  4. Acanthosis – thickening of stratum spinosum. Orthokeratosis – thickening of the corneum layer without retention of nuclei.

  5. Inflammatory cells: neutrophils, macrophages, and plasma cells predominate.

  6. Neutrophils

  7. What are these?? • Protozoal pseudo cysts! Differentials include: • Sarcocystis • Toxoplasma • Neospora • Trypanosoma Immunohistochemistry was positive for Neospora, Neospora titer was high, and PCR on tissue samples was positive for Neospora.

  8. Contributor morphological diagnosis:1. Moderate to severe, chronic, follicular and epidermal hyperplasia and hyperkeratosis with intra-keratinocyte protozoal pseudocysts DDx: Neospora, 2. Moderate to marked, diffuse, interstitial pyogranulomatous dermatitis with intrahistiocytic, intraendothelial and free protozoal zoites: DDx: Neospora

  9. Cutaneous Neosporosis is an unusual presentation, which might have occurred in this patient secondary to the immunosuppressive therapy used to control her atopy. Neospora is more commonly associated with neurological signs in dogs and abortion in cattle.

  10. Neospora life cycle http://www.ars.usda.gov/

  11. Visit the AFIP WSC website for more cases!http://vp5.afip.org/dodvpr/wsc.php

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