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TCPTP Gene ( PTPN2)

Mutation in pseudogene. Deletion or insertion. In frame stop codon. Identification of two retrotransposed genomic sequences on chromosome 1q25.1 and 13q12.3 with homology to TCPTP cDNA The gene structure and cDNA of TCPTP is compared to pseudogenes TCPTP-P1 and TCPTP-P13. 9a. 348. 381.

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TCPTP Gene ( PTPN2)

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  1. Mutation in pseudogene Deletion or insertion In frame stop codon Identification of two retrotransposed genomic sequences on chromosome 1q25.1 and 13q12.3 with homology to TCPTP cDNA The gene structure and cDNA of TCPTP is compared to pseudogenes TCPTP-P1 and TCPTP-P13 9a 348 381 415 Exon 1 2 3 4 5 6 7 8 3’ UTR TC48 1 23 24 53 54 88 89 120 121 165 166 235 236 286 287 347 (1843) AATAAA TAG TCPTP Gene (PTPN2) 5’ UTR 9b 10 348 381 382 387 ATG (90) (100) (98) (137) (209) (161) (223) 3’ UTR TC45 ATTAAA TAG 1 387 TCPTP cDNA 5’ UTR 3’ UTR TC45 AAAAAAA TAG (348) ATG 95% 1 23 387 54 TCPTP-P1 Pseudogene Sequence from Exon 2 deleted (76) ATG AAAAAAA (348) TAG 94% 387 1 TCPTP-P13 Pseudogene (3) ATG (206) TAG PTP Motifs: NxxKNRY…DxxRVxL…DYINA…YIATQGP…TxxDFWxMxW…IVMxT…KCxxYWP…WPDxGxP…PxxVHCSAGxGRTG…QTxxQYxF http://ptp.cshl.edu or http://science.novonordisk.com/ptp Andersen et al (FASEB J) 2003

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