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PHARM 3823 Health & Biostats Evidence-Based Medicine or Please Pass the PICO…

PHARM 3823 Health & Biostats Evidence-Based Medicine or Please Pass the PICO…. Frederic Murray Assistant Professor MLIS, University of British Columbia BA, Political Science, University of Iowa Instructional Services Librarian Al Harris Library frederic.murray@swosu.edu. Peer Reviewed.

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PHARM 3823 Health & Biostats Evidence-Based Medicine or Please Pass the PICO…

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  1. PHARM 3823Health & BiostatsEvidence-Based Medicineor Please Pass the PICO… Frederic Murray Assistant Professor MLIS, University of British Columbia BA, Political Science, University of Iowa Instructional Services Librarian Al Harris Library frederic.murray@swosu.edu

  2. Peer Reviewed

  3. Evidence Based Medicine • Evidence-based medicine (EBM) is using and carrying out practices based on the best available knowledge. Clinical Expertise EBM Best Research Patient Preferences

  4. Why Evidence Based Medicine? • Exponential Growth in Medical Literature • Impossible for Medical Practitioners to keep up • http://tinyurl.com/d9dvuz5

  5. Why Evidence Based Medicine? • There are 7827 articles relevant to family practice published every month • That’s 17 articles a day (every day) to keep up…20 hours a day reading.

  6. Why Evidence Based Medicine? • There are a lot of Evidence Based Review Sources that Synthesize and critically appraise healthcare literature • They can be found in Your Library • Also….you’ll be needing this again in Pharm 4302 Drug Information

  7. Yale University School of Medicine Filtered Information Appraises the quality of studies and often make recommendations for practice UnfilteredEvidence is not always available via filtered resources. Searching the primary literature may be required

  8. Evidence-Based MedicineFive fundamental steps

  9. Step 1: Formulating a well-built question • Step 2: Identifying articles and other evidence-based resources that answer the question • Step 3: Critically appraising the evidence to assess its validity • Step 4: Applying the evidence • Step 5: Re-evaluating the application of evidence and areas for improvement

  10. The fundamental skill necessary to conduct evidence-based medicine is learning to design a Well-Built Clinical Question.

  11. Step 1: Well Built Question • With clinical cases, there is often a barrage of details to digest. • To effectively search EBM resources, you need to decide what details are important.

  12. Step 1: Well Built Question • what about the Population? • what about the Intervention? • what about the Comparison? • what about the Outcome? PICO P The patient’s disorder or disease I The intervention or finding under review C A comparison intervention (if applicable) O The outcome

  13. Pico: Example • “In a 55-year-old man with a 35-year-old history of chronic smoking, would the administration of bupropion as compared to a nicotine replacement therapy (NRT) be a better therapy in causing long-term abstinence from smoking?

  14. PICO Example • “In a 55-year-old man with a 35-year-old history of chronic smoking, would the administration of bupropion as compared to a nicotine replacement therapy (NRT) be a better therapy in causing long-term abstinence from smoking?

  15. PICO Example

  16. PICO: A State of Mind • A systematic way to identify important concepts in a case • Formulate a question for searching • Often you will often not have a comparison intervention

  17. Framing Good Questions • Describe the subject • How would I describe a group of patients similar to this one?” • Define which intervention • x-ray versus an MRI • Define the type of outcome • changes in a physical sign • outcome of a diagnostic test • response to therapy

  18. Class Exercise: Worksheet 1# • A nine-year-old girl presents in the ER with diffuse abdominal pain and loss of appetite. You suspect appendicitis, and need to decide which imaging modality is best for making the diagnosis—CT or ultrasound.

  19. Class Exercise: Worksheet 1# P Child with suspected appendicitis I CT C Ultrasound O Reliable diagnosis of appendicitis Is ultrasound or CT better for diagnosing appendicitis in a child?

  20. Step 2: Database/Resource Searching These resources generally fall into three categories • General information (background) resources • Filtered resources • Unfiltered resources.

  21. Build a Broader Lexicon: (MeSH)Worksheet 1# • Use MeSH to discover new terms • Search MeSH to find new entry terms for ultrasound… (in class we’re only concerned with the C in PICO…[for now]) MeSH is the National Library of Medicine's controlled vocabulary thesaurus

  22. General Resources • DeGowin’s Diagnostic Examination • Ebrary • Current Diagnosis and Treatment • Ebrary • Drug information handbook –Lexi-Comp • 2nd floor Library

  23. Filtered Resources • Used to decide on a course of action for a patient (diagnosis, treatment, etc.) • Clinical experts pose a question and then synthesize "evidence" to state conclusions based on the available research. • The literature has been searched and results evaluated to provide an answer to a clinical question

  24. Filtered Resources • Annual Reviews Online • Cochrane Database of Systematic Reviews (CDSR) • National Guideline Clearinghouse

  25. National Guideline Clearinghouse • Hypertension • Age of Target Population • Guideline Category • Intended Users

  26. Unfiltered Resources • Search the unfiltered resources to see if any new research has been done • Unfiltered resources provide the most recent information…but • Not designed for answering clinical questions • Evaluation takes time, effort and expertise

  27. Unfiltered Resources • Medline • Medline PubMed • CINAHL • OVID

  28. Search Example

  29. Class Exercise:Search Otitis Media • Cochrane Database of Systematic Reviews (CDSR) Filtered • MedLine Unfiltered • MeSH/DeGowin’s Diagnostic Examination

  30. Step 3: Critical Appraisal • If the study is from a primary source (one that provides original data on a topic with no commentary) • Do a “validity” (closeness-to-truth) check Dachs, R., Darby-Stewart, A., & Graber, M. (2012). Antibiotics for acute otitis media in young children: the case of the shifting end points. American Family Physician, 85(2), 104.

  31. Step 3: Critical Appraisal • Diagnosis • Therapy • Harm • Prognosis

  32. Step 3: Critical Appraisal Diagnosis Was the assignment of patients to treatment groups randomized? Were all enrolled patients accounted for at the conclusion of the study? Were the treatment groups similar at the start of the study? Therapy • Did patient sample include appropriate spectrum of patients to those found in general practice? • Was the gold standard applied to all cases?

  33. Step 3: Critical Appraisal Harm Prognosis Was the patient sample representative? Was the length of the follow-up adequate? Was the follow-up complete? • Were exposures and outcomes measured similarly? • Was the follow-up adequate?

  34. Class Exercise: Therapy Questions Dachs, R., Darby-Stewart, A., & Graber, M. (2012). Antibiotics for acute otitis media in young children: the case of the shifting end points. American Family Physician, 85(2), 104. • Was the assignment of patients to treatment groups randomized? • Were all enrolled patients accounted for at the conclusion of the study? • Were the treatment groups similar at the start of the study?

  35. Step 4: Applying the Evidence • Decide how the study and/or other information applies to your question • Diagnosis • Therapy • Harm • Prognosis

  36. Step 4: Applying the Evidence Diagnosis Therapy According to the study results how much would my patient benefit from the treatment? • Is the test available, accurate and affordable? • Can I estimate the pretest probability of the disease in question?

  37. Step 4: Applying the Evidence Harm Prognosis How will the evidence influence my choice of treatment? • Can the study results be applied to my patient? • Are there alternative therapies? • What is my patient’s risk for adverse effects?

  38. Step 5: Re-evaluating the Evidence • Was the diagnosis and treatment successful? • Is there new information/data in the literature? • How can I improve and/or update my clinical decisions? HOW TO MANAGE ALL THIS INFORMATION?

  39. Class Exercise Worksheet 1# • Research the PICO Question: Is ultrasound or CT better for diagnosing appendicitis in a child? • Select two filtered & one unfiltered database • Record your findings ( hint: use the abstracts)

  40. Class Exercise Worksheet 2# • Develop PICO Questions for the case studies. • Search CDSR or Annual Reviews to answer your question • List Citation (APA)

  41. Questions? • Contact me: • Frederic Murray • 774-7113 • frederic.murray@swosu.edu

  42. Why Evidence Based Medicine Slide • In Library Land I am concerned with the process of solving information problems in the workplace • Differences between Competencies/ Strategies/Methodology • Work place moves more quickly and less predictably than academic calendar

  43. Thanks!

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