1 / 2

Agonists and Antagonists

Agonists and Antagonists. Agonists interact with receptors to produce the same cellular effect that is seen with the naturally occurring binding chemicals (ligands) eg salbutamol (eg Ventolin) – agonist at beta 2 receptors; stimulation results in smooth muscle relaxation

sandra_john
Download Presentation

Agonists and Antagonists

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Agonists and Antagonists • Agonists interact with receptors to produce the same cellular effect that is seen with the naturally occurring binding chemicals (ligands) • eg salbutamol (eg Ventolin) – agonist at beta2 receptors; stimulation results in smooth muscle relaxation • Antagonists interact with receptors and block the effects of the naturally occurring ligands • eg ranitidine (eg Zantac) – antagonist at histamine H2 receptors; blockade reduces acid secretion in the stomach

  2. Problems with relying on acid secretion as sole mechanism of peptic ulcer healing • Treatment has to be continuous. After cessation of therapy acid secretion quickly rises and ulcer recurrence rates are high (70% in 12 months for duodenal ulcers) • Inhibition of acid secretion does not eradicate H Pylori • However acid secretionis valuable in the healing and prevention of ulcers due to NSAIDs

More Related