'Receptor tyrosine kinases' presentation slideshows

Chapter 16, see p330 in text book Cell-to-Cell Signaling: Hormones and Receptors

Chapter 16, see p330 in text book Cell-to-Cell Signaling: Hormones and Receptors. signaling molecules receptors signal transduction. Overview of Extracellular Signaling. (1) synthesis and (2) release of the signaling molecule; (3) transport of the signal to the target cell;

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Intracellular Communication: Different Receptors Types

Intracellular Communication: Different Receptors Types. G Protein Coupled Receptors (GPCR). A G-Protein-Coupled Receptor Or G Protein-linked Receptor 7 transmembrane domains. The disassembly of G-Protein upon stimulation

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Overview: The Cellular Internet

Overview: The Cellular Internet. Cell-to-cell communication is essential for multicellular organisms Biologists have discovered some universal mechanisms of cellular regulation.

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caffeine

Signaling via Ligand-Receptor Binding. Agonist - ligand binding to a receptor and eliciting a response. caffeine. Antagonist - ligand binding to a receptor but not eliciting a response. Brain sleep signal. R + L ? R?L K d = [R][L]/[R?L]. Bacterial Quorum Sensing.

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Lecture 3 February 7, 2008

Lecture 3 February 7, 2008. Intracellular signaling by receptor-activated cascades. Cell Structure, Signaling and Differentiation Winter Quarter, 2008 Gerry Weinmaster 390A Basic Science Research Building gweinmaster@mednet.ucla.edu.

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Receptor Tyrosine Kinases

Receptor Tyrosine Kinases. Ahu Karademir Andrei Vasiliev. Receptor tyrosine kinases (RTK). Cell-surface receptors with intrinsic enzymatic activity (tyrosine kinase) Cytoplasmic domain has tyrosine kinase activity Mostly receptors for peptide/protein growth factors

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Signal Transduction

Signal Transduction. Channels Enzyme-linked receptors Receptor tyrosine kinases Tyrosine kinase associated receptors Receptor tyrosine phosphatases Transmembrane receptor S/T kinases Transmembrane guanyl cyclase G-proteins. Channels. Voltage-gated Ligand-gated Mechanosensitive.

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Protein Kinases

Protein Kinases. Primary elements in signal transduction - Phosphorylated residues by protein kinases: S, T, Y A Protein kinase can ? hundreds of target proteins , thereby amplifying signals. - Activator of Protein Kinases: light, pathogen, growth regulators,

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Cells communicate by sending and receiving signals.

Cells communicate by sending and receiving signals. Signal is sent ? received ? signal transduction pathway. --series of steps that elicit a specific cellular response. Cells close together can send signals directly by direct contact or through gap junctions or plasmodesmata.

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Cell Signaling

Cell Signaling . Lecture 10. Receptor Tyrosine Kinases. Regulate cell proliferation, differentiation, cell survival and cellular metabolism The signaling molecules that activate RTK are soluble or membrane bound peptide or protein hormones Examples; Nerve growth factor (NGF)

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