'Recombination frequency' presentation slideshows

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Chromosomal Basis of Inheritance

Chromosomal Basis of Inheritance. Thomas Hunt Morgan. Performed Experiments and provided convincing evidence for chromosomes. Studied Drosophila Easy to Culture Breed Extremely fast Short Generation time Four pair of chromosomes that are easily observed in the microscope. Drosophila.

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Human Gene Mapping and Disease Gene Identificaton

Human Gene Mapping and Disease Gene Identificaton. Paul Coucke Jan Hellemans Andy Willaert. 10. Chapter. Chapter 10. The genetic landscape of the human genome Mapping human genes by linkage analysis Mapping of complex traits From gene mapping to gene identification. Aims.

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LINKAGE AND CHROMOSOME MAPPNG

LINKAGE AND CHROMOSOME MAPPNG. Prepared by - RAKESH CHOUDHARY M.Sc.(AGRI) GENETICS AND PLANT BREEDING. WELCOME. Linkage and Chromosome Mapping. Linkage and Chromosome Mapping.

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Gene Linkage and Genetic Mapping

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A tetrad:

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Grouping loci

Grouping loci. Criteria Maximum two-point recombination fraction Example - r ij ? 0.40 Minimum LOD score - Z ij For n loci, there are n ( n -1)/2 possible combinations that will be tested Expect ? probability of false positives Significant probability value - p ij

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Meiosis

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Mapping populations

Mapping populations. Controlled crosses between two parents two alleles/locus, gene frequencies = 0.5 gametic phase disequilibrium is due to linkage, not other causes Examples Backcross (BC 1 or BC 2 ) F 2 or F 2:3 Recombinant inbred lines (RIL) Doubled haploid (DH).

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Chapter 15

Chapter 15. Chromosomal Basis Of Inheritance. Chromosome Theory of Inheritance. Mendelian genes have specific loci on chromosomes and it is the chromosomes that undergo segregation and independent assortment not the alleles. I. Morgan and Friends.

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Bassem M. Shoucri Bio Sci D145 January 9, 2014

Bassem M. Shoucri Bio Sci D145 January 9, 2014. Why do we want to map genomes?. Clinical applications! Identify genes causing diseases Treatment? Compare genomes of different species Understand overall genome structure Understand relationship between genes and regulatory elements

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double edged sword:

double edged sword:. pediatric leukemia and the biology of adaptive immunity. Outline. pediatric leukemia and V(D)J Recombination an in vitro assay that assesses aberrant V(D)J recombination in response to environmental exposure mechanisms of genotoxin-induced recombination.

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The Chromosomal Basis for Inheritance

The Chromosomal Basis for Inheritance. Thomas Hunt Morgan. Early 1900s Columbia University (New York) Studied genetics of Drosophila melangaster (the common fruit fly). Why Drosophila?. Only four pairs of chromosomes A single mating produces hundreds of offspring

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Linkage genes and genetic recombination

TABUK UNIVERSITY Faculty of Applied Medical Sciences Department of Laboratory Technologies. Linkage genes and genetic recombination. AY: 1433-1434/2012-2013 Lecture 5.

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The Chromosomal Basis of Inheritance

The Chromosomal Basis of Inheritance. Chapter 15. Agenda. Warm up: Hemophilia case study Discuss genetics problems in group and as class Review blue people case study

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Announcements

Announcements. Exam 1 is on Monday Multiple choice: 15-20 questions Matching: 8-10 questions Problems: 4-6 multipart problems (probably ~50% of total points) Multiple choice/matching problems from lecture, key terms/concepts, and homeworks (covers reading up through Chapter 5)

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Chromosomal Basis of Inheritance

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Chromosome Mapping

Chromosome Mapping. Recombination : in meiosis , recombination generates haploid genotypes differing from the haploid parental genotypes . The recombinants can be most easily visualized by test crosses .

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