1 / 118

HORMONAL MODULATION AND ANTI-AGING MEDICINE

HORMONAL MODULATION AND ANTI-AGING MEDICINE. Dr Odilza Vital M.D. Endocrinologist Geriatrician. ANTI-AGING MEDICINE IS THE PRESENT AND FUTURE!. THE ERA OF PREVENTION !. THE HORMONAL MODULATION TO BALANCE PHYSICAL, MENTAL AND EMMOTIONAL STATUS !.

thad
Download Presentation

HORMONAL MODULATION AND ANTI-AGING MEDICINE

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. HORMONAL MODULATIONANDANTI-AGING MEDICINE Dr Odilza Vital M.D. Endocrinologist Geriatrician

  2. ANTI-AGING MEDICINE IS THE PRESENT AND FUTURE!

  3. THE ERA OF PREVENTION !

  4. THE HORMONAL MODULATION TO BALANCE PHYSICAL, MENTAL AND EMMOTIONAL STATUS !

  5. LIFE EXPECTANCY REQUIRES HORMONAL MODULATION THERAPYWHY IS THAT?

  6. QUALITY OF LIFE!

  7. HORMONAL MODULATION =HORMONAL BALANCE • HORMONES ACT SYNERGISTICALY • ONE AFFECTS THE OTHERS FUNCTION • PRODUCTION • RESPONSE • CELL RECEPTORS SENSITIVITY

  8. MY EXPERIENCE WITH ANTI-AGINGAND BLUE TENT MY EXPERIENCE WITH ANTI-AGINGAND BLUE TENT

  9. WHAT TO DO IN HORMONAL MODULATION? CORRECTION OF HORMONAL DEFICIENCY CORRECTION OF HORMONAL OVERPRODUCTION

  10. HORMONAL MODULATION • AGING PROCESS IS ASSOCIATED WITH DECREASE OF MOST OF HORMONES LIKE: SEXUAL HORMONES, DHEA, HGH, T4? MELATONIN • AGING PROCESS IS ASSOCIATED WITH INCREASE OF SOME HORMONES LIKE: INSULIN, CORTISOL, PTH

  11. ENDOCRINE SYSTEM…  BIG ORCHESTRA

  12. HORMONE DEFICIENCY AND OVERPRODUCTION PROMOTE DISEASES ASSOCIATED WITH THE AGING PROCESS

  13. HGHHUMAN GROWTH HORMONE

  14. HGHSTIMULATES PROTEIN SYNTHESIS, CELL MULTIPLICATION

  15. BENEFITS OF THE USE OF HGH IN ADULTS WITH DEFICIENCYSUPPORT THE SHARP DECLINE IN THE ELDERLY 20 y 60 y

  16. HGH • THE HGH RESTORES MUSCLE MASS AND STRENGTH OF THE ADULT WITH DEFICIENCY

  17. HGH • IT ACCELERATES THE HEALING OF SURGICAL WOUNDS • AN IMPORTANT ROLE IN THE IMMUNE SYSTEM • USED TO PREVENT AND REVERSE CACHEXIA IN HIV PATIENTS

  18. HGH • SECRETION IN PULSES • THE HGH IS A SINGLE CHAIN OF 191 AMINO ACIDS 75% • 22 KD PROTEIN, 20 KD • NO GLYCOGEN • HAS TWO BRIDGES S = S

  19. HGH • VALUES RANGE FROM UNDETECTABLE TO 40MCG/DL • THE SECRETION IS AFFECTED BY FOOD • DECREASED IN HYPERGLYCEMIA • INCREASED BY AMINO ACIDS AND HYPOGLYCEMIA

  20. FACTORS THAT INCREASE SECRETION OF HGH • SOMATOTROPIN: GH-RH(HYPOTHALAMUS) • HYPOGLYCEMIA • AMINO ACIDS • ACUTE STRESS

  21. FACTORS THAT REDUCE THE SECRETION OF HGH  • IGFs= SOMATOMEDIN C (NEGATIVE FEED-BACK) • HYPERGLYCEMIA • CHRONIC STRESS • AGING PROCESS

  22. HGH • HOW TO EVALUATE HGH DEFICIENCY IN AGING PROCESS?

  23. IGFsInsulin Growth Factor-s(Mediate HGH action)

  24. HGH • IGF SMALL MOLECULE PRODUCED BY MOST TISSUES, ESPECIALLY LIVER • FREE : IGF • LINKED TO PROTEIN: IGF-BP 1,2,3,4,5

  25. HGH • THE IGF-1 MEDIATE THE PHYSIOLOGICAL ACTIONS OF HGH • THE IGF-BPs MODULATE THE ACTIONS OF IGFs IN THE TARGET CELLS • IGF-BPs CHANGE BIOAVAILABILITY OF IGFs TO THE TISSUES

  26. DIAGNOSIS HGH DEFICIENCY • IGFs: SECRETION REFLECTS THE OVERALL PRODUCTION IN THE LAST 24 HOURS • USED IN ADULTS WITH DEFICIENCY

  27. DIAGNOSIS • IN PATHOLOGICAL DEFICIENCY - DYNAMIC TESTIN CHILDREN ONLY: CLONIDINE, INSULIN, L-DOPA, PROPANOLOL, GLUCAGON : TEST : HGH • IN AGING PROCESS : TEST :IGFs

  28. ADMINISTRATION: PARENTERAL

  29. THE FIRST EVIDENCE OF BENEFICIAL USE OF HGH IN ADULTS WITH DEFICIENCY 1962

  30. HGHKEY FEATURES OF THE SYNDROME OF GH DEFICIENCY IN ADULTS

  31. SYMPTOMS LOSS OF PSYCHOLOGICAL WELL-BEING • REDUCED VITALITY AND ENERGY • DECREASED PHYSICAL ACTIVITY • DEPRESSED MOOD • EMOTIONAL LABILITY • ANXIETY • DISORDERS OF SEXUAL FUNCTION • SOCIAL ISOLATION 

  32. SIGNS CHANGES IN BODY COMPOSITION • REDUCTION OF LEAN BODY MASS • INCREASED FAT • INCREASED VISCERAL FAT • REDUCTION OF BODY WATER • REDUCTION OF BONE DENSITY

  33. SIGNSDECREASED MUSCLE STRENGTH DECREASED ABILITY TO EXERCISE INCREASED BODY MASS INDEX (BMI) INCREASED WAIST / HIP RATIO

  34. ABNORMAL LIPID PROFILE • INCREASE IN TOTAL CHOLESTEROL • INCREASED LDL • REDUCTION OF HDL

  35. INCREASED RISK OF CVD • INCREASED PAI-1 (PLASMINOGEN ACTIVATION INHIBITOR) • INCREASED OF FIBRINOGEN

  36. HGH DOSESBY THE BODY WEIGHT ?

  37. CURRENT CONCEPTS THE GROWTH HORMONE RESEARCH SOCIETY SUGGESTS: INCREASING DOSES OF GH, NOT BASED ON WEIGHT 

  38. DOSESPATIENTS SHOULD START TREATMENT WITH LOW DOSES(0.15 TO 0.3 MG / DAY OR 0.45 TO 0.9 IU / DAY);(RARELY EXCEEDS 1 MG / DAY: 3 IU / DAY)

  39. MONITORING THE DOSE GRADUALLY ACCORDING TO CLINICAL AND BIOCHEMICAL RESPONSESWOMEN REQUIRE HIGHER DOSES, THE ELDERLY REQUIRE LOWER DOSES

  40. THE ADMINISTRATION SHOULD BE DAILY, AT NIGHT, SUBCUTANEOUSLY.

  41. CONTRAINDICATIONS FOR USE OF HGH:  • NON COMPENSATED DIABETES MELLITUS • HEART FAILURE • SMOKING • MALIGNANT TUMORS OF ANY ORIGIN IN ACTIVITY

  42. DIABETES;HYPERTENSION;CARDIOVASCULAR DISEASE; IATROGENIC ACROMEGALY;CANCER??? SIDE EFFFECTS OF GH ABUSE

  43. FEMALE SEXUAL HORMONES

  44. CLIMACTERIC SYNDROMEPRE-MENOPAUSE • HORMONAL CHANGES : LOSS OF CYCLE 2nd phase • CLINICAL MANIFESTATIONS • SIGNS AND SYMPTOMS • LABORATORY : LOW PROGESTERONE

  45. MENOPAUSE • DEFINITION: AMENORRHEA • HORMONAL CHANGES • CLINICAL MANIFESTATIONS • SIGNS AND SYMPTOMS • LABORATORY

  46. EFFECTS OF FEMALE SEXUAL HORMONES • ESTROGENS ARE PRODUCED IN FOLICULAR CELL: STIMULATES CELL PROLIFERATION • PROGESTERONE IS PRODUCED BY CORPUS LUTEUM: MATURE CELLS STIMULATED BY ESTROGENS

  47. TESTOSTERONE • LIBIDO • BONE DENSITY • MUSCLE STRENGTH • MOOD

  48. CLINICAL CHANGES OF PROGESTERONE DEFICIENCY • ENDOMETRIAL HYPERPLASIA • EXACERBATION OF PMS • MENSTRUAL IRREGULARITIES • BREAST CANCER?

  49. CHANGES OF CLINICAL ESTROGEN DEFICIENCY  • VASOMOTOR SYMPTOMS • BONE LOSS • ATHEROSCLEROSIS AND CVD • INSOMNIA • EMOTIONAL LABILITY • UROGENITAL ATROPHY • DEMENTIA

More Related