1 / 34

Inflammation & Repair

Inflammation & Repair. Chronic Inflammation. Chronic Inflammation. Cell Types in Chronic Inflammation. Macrophages Types of Macrophages (fixed) Kupffer cells - liver Pulmonary alveolar macrophages Histiocytes - connective tissue Microglia - brain Osteoclasts - bone Spleen/lymph nodes

vui
Download Presentation

Inflammation & Repair

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Inflammation & Repair

  2. Chronic Inflammation

  3. Chronic Inflammation

  4. Cell Types in Chronic Inflammation • Macrophages • Types of Macrophages (fixed) • Kupffer cells - liver • Pulmonary alveolar macrophages • Histiocytes - connective tissue • Microglia - brain • Osteoclasts - bone • Spleen/lymph nodes • Langerhans cells - epidermis

  5. Other Cell Types • Lymphocytes • Plasma cells • Eosinophils • IgE mediated, parasitic infections • Mast Cells

  6. Granulomatous Inflammation • Granulomatous inflammation • focal accumulations of activated macrophages with an epithelial-like (epithelioid) appearance. • Granuloma • microscopic aggregation of epitheliod macrophages surrounded by a collar of lymphocytes and occasionally plasma cells.

  7. Granulomatous Inflammation - TB

  8. Granulomatous Inflammation - TB

  9. Granulomatous Inflammation - TB

  10. Granulomatous Inflammation - TB

  11. Granulomatous Inflammation - TB

  12. Healing and Repair

  13. Cell Types with Different Regenerative Capacities

  14. Resolution vs Repair

  15. Granulation Tissue • Proliferation of new blood vessels and fibroblasts • Fibroblasts  myofibroblasts

  16. Granulation Tissue

  17. Granulation Tissue

  18. Wound Healing • Primary union (healing by 1st intention) • healing of a clean surgical incision • very little tissue damage is present • Secondary union (healing by 2nd intention) • healing of a large tissue defect

  19. Healing by First Intention Healing by Second Intention 24 Hours

  20. Healing by First Intention Healing by Second Intention 3 to 7 Days

  21. Healing by First Intention Healing by Second Intention Weeks

  22. Aberrations of Wound Healing • Inadequate granulation tissue/healing • Excessive repair • Hypertrophic scar • Keloid • Contractures

  23. Hypertrophic Scar

  24. Keloid

  25. Conditions Inhibiting/Delaying Wound Healing • Poor local vascular supply • Poor oxygenation, decreased bacterial resistance, low temperature, and an acid pH • Deficiencies of vitamin C, protein, zinc • Infection • Tissue necrosis • Foreign material delay healing and acts as a nidus for bacterial infection • Excessive movement

  26. Extracellular Matrix- Collagen - • Tropocollagen is the basic unit • Intracellular • procollagen • Extracellular • procollagen cleavage & lysine oxidation  cross-linking •  tensile strength

  27. Wound Healing • Replacement of Type III collagen by Type I in wound healing will have a maximal tensile strength of 70-80% of normal (takes about 3 months)

  28. Outcomes of Acute Inflammation

  29. The End Chronic Inflammation & Repair

More Related