Isocitrate dehydrogenase (IDH)

Jul 03, 2019

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Isocitrate dehydrogenase (IDH) is an important enzyme in the tricarboxylic acid cycle, which occurs in the mitochondrial matrix. IDH is responsible for catalyzing the reversible conversion of isocitrate to alpha-ketoglutarate and CO2 in a two-step reaction. The first step of the reaction involves the oxidation of isocitrate to the intermediate oxalosuccinate. The second step of the reaction looses the beta-carboxylate of the oxalosuccinate intermediate as carbon dioxide leaving alpha-ketogluterate. During the catalyzation of isocitrate to alpha ketoglutarate either NADH or NADPH is produced along with carbon dioxide.

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Isocitrate dehydrogenase (IDH)

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Isocitrate Dehydrogenase (IDH) Website: https://www.bocsci.com/tag/isocitrate-dehydrogenase-idh-216.html Address: 45-16 Ramsey Road, Shirley, NY 11967, USA