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1. HEPBEST 25 MG Drug profile for HepBest tablet HepBesttablets are primarily used in hepatitis infection condition, is in chronic stage. HepBesttablets are only used by the patients who are having a valid prescription HepBest tablets are containing an anti-viral agent known as Tenofovir Alafenamide which may not cure the infection but may suppress the growth of virus. HEPBEST 25 MG Trade name: HepBest Active component: Tenofovir Alafenamide

2. Strength: 25mg Mfg: Natco Pack: 30 tablets in a container Category: Anti-hepaciviral activity Prescribing information of HepBest The most frequently used anti-viral agent like Tenofovir Alafenamide is primarily indicated for the treatment of chronic hepatitis B viral infection occurred in adults patient with compensated liver damage. Mechanism of HepBest HepBest worked in the body by some component incorporates; For the most part HepBest containing tenofovir Alafenamide is a prodrug which is changed over into dynamic frame in-vivo Tenofovir Alafenamide has cell penetrability property which is lipophilic in nature, infiltrates into hepatocytes by latent dissemination strategy and additionally by hepatic return transporters OATP1B1 and OATP1B3 In-vivo, tenofovir Alafenamide is changed into tenofovir a parent compound by experiencing hydrolysis with the chemical carboxylesterase 1 which is happen in hepatocytes cell This dynamic frame tenofovir is phosphorylated into tenofovir diphosphate by cell kinase compounds TAF has pharmacologically dynamic compound known as tenofovir diphosphate which is in charge of viral multiplication denial by means of imbuing into infection DNA with the assistance of turnaround transcriptase chemical which causes viral DNA chain end Absorption Maximum plasma concentration time of TAF 0.48 hours

3. Distribution TAF is largely bound to human plasma protein at 80% Protein binding data occurs in vivo The blood plasma ratio of TAF is 1.0 Metabolism The metabolism of TAF occurs with the help of; Carboxyl esterase 1 Cathepsin A CYP3A Excretion Nearly 80% of TAF get metabolized and reaches its half life at 0.51 hour <1% of metabolite released through urine 31.7% excreted via feces When to take the HepBest tablets HepBesttablets should be taken with food Dosage regimens of HepBest Before initiate the treatment with HepBest tablets, patients must be investigate whether they are suspected with HIV 1 infection or not. The suggested dosage of HepBest is 25mg should be administered as a single dose.

4. In both mild to moderate liver and kidney impaired patients, dosage adjustment should not be allowed; whereas severe conditions, HepBest not recommended. HepBest caused side effects The most serious adverse effects; Serious exacerbation of hepatitis B infection Out breaking or worsening of renal damage Lactic acidosis Hepatomegaly with steatosis Common side effects; Fatigue Headache Cough Back pain Nausea Abdominal pain Loss of bone mineral density Glycosuria Increase in lipase & amylase Increasing in serum lipids Drug- drug interaction of HepBest

5. HepBest tablets with P-gp or BCRP inhibiting drugs, causes variation in absorption of TAF; this may leads to adverse effects. HepBesttablets with P gp or BCRP inducing drugs causes depletion of absorption of TAF leads to increasing the concentration of TAF HepBest tablets with renal function reducing drugs may leads to increasing the concentration and causes serious adverse effects HepBest tablet combined with anti-convulsants leads to decreasing the effect of concentration of TAF HepBest tablet combined with anti-mycobacterials causes reducing the effect of concentration of TAF HepBesttablets concomitant use of herbal product like st, John’s wort, causes decreasing the TAF concentration. Food drug interaction of HepBest; Minor food drug interaction may occur; alcohol containing food items should not be suggested. Consult with physician about the dietary. Possible contraindications of HepBest No specific contraindication occurs, if some patients may contraindicate to TAF causes anaphylactic reactions. Safety measures Aggravation of hepatitis B infection: Check the patient history before starting the treatment Exposure of advancement of HIV-1 resistance: Due to this condition, HepBest tablets are not suggested for HIV-1 infections

6. New commencement of renal damage: To avoid concomitant use of HepBestwith renal function depleting drugs Lactic acidosis or hepatomegaly with steatosis: Stop the therapy withHepBest Pregnancy and lactation HepBesttablets are probably used in pregnancy conditions, only after knowing the risk of the product associated to fetus. Breast feeding should not be suggested. Storage and handling HepBesttablet container should be kept at below 30oC Protect the container from heat, moisture & heat Missed dose In case of missed dose, get advice from medical practitioner and their instruction; otherwise avoid the missed dose and follow the regular schedule. Over dosage If over dosage occurs during the therapy; Provide the patients with supportive measures Monitor the signs & symptoms Hemodialysis is done, to eliminate the TAF content with the range of 54%. CONTACTS Phone : +919940472902 USA Toll-Free Call : +18882264402 Email:millionhealthpharmaceuticals@gmail.com WEBSITE: https://millionpharma.us/