Top Companies Empowering Access to Healthcare 2024

1. June Issue 08 2024 Top Companies Empowering Access to Healthcare 2024 Prasanna Parthasarathy CEO Medvantx Pioneering Tomorrow's Healthcare Today

2. Be?er Health and a better way of life.

4. Editor’s Note Innova?on Meets Equity in Healthcare

5. I n an era where digital transformation touches every aspect of our lives, healthcare stands at the forefront of this revolution. As we witness the dawn of a new age in medical accessibility, our latest edition, ‘Top Companies Empowering Access to Healthcare 2024,’ shines a spotlight on the industry leaders reshaping the world of care delivery. altering how we think about and interact with healthcare services. These organizations understand that advancing patient care is not just about developing new treatments; it's about reimagining the entire care experience. By embracing patient-centered approaches and leveraging innovative technologies, they are working tirelessly to ensure equitable access to high-quality care for all individuals, regardless of their circumstances. The ongoing digitization of healthcare has opened doors previously thought impenetrable, creating pathways to quality care for those who need it most. This edition is our tribute to the visionaries who have dedicated themselves to bridging the gap between the latest medical services and the communities they serve. As we delve into the stories of these healthcare pioneers, we invite you to explore how they are tackling healthcare disparities, improving health outcomes, and enhancing quality of life for patients across the globe. Their work reminds us that the future of healthcare is not just about treating illness, but about empowering individuals to take control of their health journey. At the heart of this transformation lies the twin pillars of accessibility and reliability. The companies we feature are redefining healthcare as an on-demand, one-stop destination for all – from those maintaining wellness to those managing acute or chronic conditions. Their innovations ensure that quality care is available anytime, anywhere, fundamentally These companies are not just changing healthcare – they're changing lives. Natalie May Natalie May - Natalie May

6. Contents Cov Sty 08. Medvantx Pioneering Tomorrow’s Healthcare Today Aies 20. Digital Twins in Healthcare Revolutionizing Patient Care Through Virtual Simulation 30. Healthcare Transformation How Telemedicine Bridges the Gap in Rural Healthcare?

7. Profile 16. TruDoc Rede?ning Healthcare with Innovation and Commitment CXOs 24. Stanislav Ostapenko From Awareness to Action: Rare Disease Day-A Global Movement for Equity 28. Virginia Spielmann Sensory Processing: The Secret Ingredient to Growing Up Healthy

8. Editor-in-Chief Chidiebere Moses Ogbodo Managing Editor Pearl Shaw Executive Editor Natalie May Visualiser David King Art & Design Head Samuel Martinez Co-designer Paul Belin Art & Picture Editor Grace Brown Business Development Manager Emily Jones Marketing Manager Bill Thompson Business Development Executives Anna Smith, Jack Miller Sales Executives Mike, Carl, Grace Technical Consultants David, Robert Assistant Technical Head Joseph Taylor Technical Head Jacob Smile Digital Marketing Manager Assistant Digital Marketing Manager SME-SMO Executive Gemson Alina Sege Daniel Jones Research Analyst Eric Smith Circulation Manager James Carter sales@insightscare.com June, 2024 Contact Us: Insights Success Media and Technology Pvt. Ltd. Survey No.133/134, Brand Square, Office No. 512, Kunjir Chowk, Pimple Saudagar, Pune, Maharashtra 411027. Phone - India: 7410033802, 8956487823 Email: info@insightscare.com For Subscription: www.insightscare.com Insights Success Media Tech LLC 555 Metro Place North, Suite 100, Dublin, OH 43017, United States Phone - +1614-602-4132 Email: info@insightscare.com For Subscription: www.insightscare.com https://twitter.com/Insightscare Follow us on : www.facebook.com/InsightsCare/ We are also available on : Copyright © 2024 Insights Success Media and Technology Pvt. Ltd., All rights reserved. The content and images used in this magazine should not be reproduced or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, without prior permission from Insights success. Reprint rights remain solely with Insights Success Media and Technology Pvt. Ltd. Insights Care is powered by Insights Success Media and Technology Pvt. Ltd.

9. TOP COMPANIES EMPOWERING ACCESS TO HEALTHCARE 2024 Featuring Person Company Brief Arnet Pharmaceutical is a pharmaceutical company that develops and manufactures generic and branded medications to make healthcare more accessible and affordable. Arnet Pharmaceutical arnetusa.com Mark Tabacinic Owner Empire Precision Plastics is a custom plastic injection molding manufacturer that provides high-quality, precision-engineered plastic components and assemblies for various industries. Empire Precision Plastics empireprecision.com Joe Buonocore Chief Executive Officer Ferriot Inc. is a full-service contract manufacturer that specializes in plastic injection molding, assembly, and value- added services for a wide range of industries. Craig Ferriot President Ferriot Inc. ferriot.com Medvantx is a specialist healthcare firm that connects patients with providers and healthcare organizations to ensure affordable, high-quality care and medication delivery. Medvantx medvantx.com Prasanna Parthasarathy Chief Executive Officer TruDoc is a healthcare technology company that offers telehealth services, remote patient monitoring, and digital health solutions to improve patient outcomes. TruDoc Mahdi Attya trudocgroup.com Chief Commercial Officer

10. PRASANNA Pioneering Tomorrow's Healthcare Today Medvantx distinguishes itself in the healthcare industry through its constant dedication to patient well-being, setting it apart from other healthcare companies. COVER STORY

11. PRASANNA Prasanna Parthasarathy CEO Medvantx

12. A A Personal Connection to Healthcare Access dvancing patient care is paramount in the quest for better health outcomes, improved quality of life and the reduction of healthcare disparities. Healthcare providers that embrace patient-centered approaches and innovative treatments ensure equitable access to high-quality care for all individuals. care, embodying the transformative mission of Medvantx—a company steadfast in its commitment to making healthcare more accessible and better for all. Prasanna shares his journey to Medvantx from an unexpected origin in high tech, initially specializing in ecommerce solutions. However, his trajectory took a turn when he ventured into healthcare with GE Healthcare in 2000. It was here that he discovered his profound passion for advancing global health, a realization that anchored him firmly in the healthcare industry. So, let’s embark on a journey through the innovative realm of healthcare with Prasanna and Medvantx and discover how they’re inspiring patient care! Insights from the CEO of Medvantx At the forefront of this mission stands Medvantx, a trailblazing healthcare company dedicated to revolutionizing the accessibility and quality of healthcare solutions. Medvantx is driven by a commitment to empower individuals to take charge of their health and well-being through innovative services and products. Leveraging state-of-the-art technology and a patient-centric approach, Medvantx endeavors to make healthcare more accessible, convenient and affordable for everyone. Prasanna shares his journey in healthcare, committed to improving access and quality of care. At Medvantx, he leads efforts to streamline pharmacy operations, ensuring seamless patient experiences. Before Medvantx, as an Operating Partner at Windrose Health Investors, Prasanna focused on strategic investments in medication management, noting, “Our focus was on enhancing healthcare delivery.” Reflecting on his transition, Prasanna underscores the unique role of the healthcare sector in shaping global well-being. At Medvantx, this mission resonates deeply with him on a personal level. The company’s dedication to improving patient access to care fuels his passion to create a significant impact in the healthcare sector. Prasanna emphasizes Medvantx’s pivotal role in bridging gaps in access to medication solutions, particularly for those who may otherwise be underserved. The company’s dedication to advancing care aligns with his professional ethos and values. Drawing from his extensive experience in the medication management sector, Prasanna saw joining Medvantx as a natural progression towards contributing to the advancement of care for millions of Americans. Built on the foundational principle of enhancing healthcare outcomes, Medvantx offers a diverse array of solutions tailored to meet the varying needs of patients, healthcare providers and payers. Whether through streamlined medication management, telehealth services or pioneering pharmacy solutions, Medvantx strives to elevate the overall healthcare experience for individuals and communities alike. With over a decade at Becton Dickinson and CareFusion Inc., Prasanna led global Dispensing businesses, refining medication and supply chain technologies that was used across 10000+ Retail and Hospital pharmacies around the world. His tenure at GE Healthcare was focused on digital health and monitoring solutions for almost a decade. Prasanna’s academic background, including degrees in Mechanical and Computer Engineering, alongside an MBA, reflects his commitment to continuous growth. Driving Access to Care In this relentless pursuit of advancing patient care, Prasanna Parthasarathy emerges as an epitome of innovation and dedication. As the CEO of Medvantx, Prasanna spearheads initiatives to streamline pharmacy operations, facilitating seamless interactions with patients. Medvantx is driven by a core mission: Advancing Access to Care Every Day. The core of its operations is devoted to bridging the gap between patients, providers, and healthcare companies, aiming to increase accessibility and enrich lives. This mission is operationalized through a range of initiatives, including Patient Assistance Programs, Cash Pay options and Considering on Medvantx’s global impact, Prasanna emphasizes their dedication to exceptional service. “Our digital pharmacy services have gained global recognition,” he asserts, “We prioritize customer satisfaction and quality healthcare.” His journey in healthcare is marked by a steadfast dedication to improving access and elevating the quality of

13. Top Companies Empowering Access to Healthcare 2024 Pharmacy Services, all facilitated by its proprietary Medvantx INSIGHTS Platform. Medvantx believes in the power of collaboration, working closely with partners to achieve greater customer centricity through world-class pharmacy services and technology. At the heart of Medvantx’s mission is the conviction that advancing patient access and well-being is crucial to the future of healthcare. This guiding principle drives every aspect of the company’s operations and strategic initiatives. The vision is clear: ‘to create access across patients, providers and healthcare, ultimately advancing care for society.’ Medvantx boasts a diverse staff dedicated to making a tangible impact on healthcare access. Their team is driven by a shared commitment to their mission and vision, working collaboratively to innovate and deliver medical solutions that improve access to care for all individuals. nationally licensed non-commercial dispensing pharmacies, Medvantx leads the way in advancing access to healthcare. integration with our pharmacy for manufacturers, offering flexibility in prescription management, addressing clinical inquiries and beyond.” In all its initiatives, Medvantx strategically begins with the ultimate goal: to facilitate access to quality healthcare not only today but also in the foreseeable future. It extends an invitation to partners to collaborate in the advancement of healthcare accessibility. Medvantx’s supply chain management sets a new standard with its unique 3- point scan process. “We are the only production team that utilizes a 3-point scan—created specifically for our pharmacy to add an additional layer of protection for our clients by having the technician scan the package for a second time where a visual and technological validation occurs,” Prasanna notes. “Most places scan package then labels and move forward. We scan package, then label, then scan package a third time to ensure the right patient delivery with each shipment.” Pioneering Patient-Centric Healthcare Medvantx distinguishes itself in the healthcare industry by consistently prioritizing patient well-being, setting it apart from other healthcare companies. Prasanna underscores its dedication, affirming, “Putting patients’ well-being first is our primary commitment.” Patient Engagement and Supply Chain Management This platform serves as a catalyst for improved access to healthcare services, offering a range of tools and solutions accessible via Cloud and mobile platforms. One of the hallmarks of Medvantx is its prestigious NABP accreditation status, signifying adherence to the highest standards of pharmacy practice. This accreditation supports Medvantx’s commitment to excellence and patient safety. By leveraging INSIGHTS and its advanced supply chain management, Medvantx redefines patient engagement and supply chain efficiency in the pharmaceutical industry. Through these innovative solutions, Medvantx paves the way for improved access to healthcare services, prioritizing patient safety and satisfaction at every step. At the heart of INSIGHTS lies “Engage,” a proprietary feature customized for both patients and providers. Available round-the-clock, Engage boasts an intuitive self-service design, granting empowerment to both patients and providers. As Prasanna elaborates, “Engage serves as a tool for patients and providers, designed to facilitate seamless self-service.” He adds, “Engage facilitates digital Guided by a clear mission to pave the path to access today, tomorrow and into the future, Medvantx’s dedicated team relentlessly pursues innovative solutions to enhance patient care and accessibility. As one of the largest

14. Keys to Success “Success is achieved through hard work, dedica?on, and a strong work ethic. Intelligence alone is not enough; determina?on is key. Find inspira?on, purpose and like-minded individuals to expand your network. Remember, success is a marathon, not a sprint. Gain a comprehensive understanding of available career possibili?es.” - Prasanna Parthasarathy

15. Medvantx’s Innovative Solutions for Safe Medication Delivery Medvantx implements innovative strategies to ensure safe and secure medication delivery, particularly through cold-chain solutions and prescription fulfillment safeguards. Leveraging its two main distribution facilities located in Sioux Falls, SD, and Louisville, KY, Medvantx achieves nationwide capability for dispensing cold-chain prescriptions, delivering to all 50 states and some territories including Hawaii and Alaska. Enabled by our committed employees, scalable tech platform, and partnerships, we believe we are uniquely positioned to serve our customers and transform lives and healthcare. a trusted expert in cold-chain medication packing and distribution. Additionally, partnerships with industry leaders like cold-chain technologies further enhance Medvantx’s capabilities in this domain, reinforcing its commitment to safe and reliable medication delivery. from across the country, ensuring a diverse and dynamic workforce. At the core of Prasanna’s leadership style is the encouragement of collaboration and the creation of an environment conducive to the cultivation of innovative ideas. “We are committed to fostering a collaborative platform where all great ideas can thrive,” he asserts. With a dual-facility setup, Medvantx mitigates risks associated with major weather events or natural disasters, ensuring uninterrupted prescription fulfillment. Additionally, Medvantx pharmacies are equipped with ample cold-chain storage and multiple temperature-controlled coolers to maintain the integrity of temperature- sensitive medications. Leadership Style and Cultural Influence Under Prasanna’s guidance, Medvantx flourishes as a forward-looking organization dedicated to consistently pushing boundaries in pursuit of its mission to enhance access to safe and effective healthcare. Prasanna affirms, “We have the experience and expertise to dispense a wide variety of cold chain prescriptions across the United States.” With approximately 25,000 cold-chain prescriptions fulfilled monthly and close to 40 percent of dispensed medications falling under the cold- chain category, Medvantx demonstrates proficiency in this specialized area. Prasanna is widely recognized for his leadership approach characterized by purpose and clarity. “I strongly advocate leading with purpose,” he affirms. “Having a clear understanding of our direction and objectives is a personal imperative that everyone must embrace as we strive to fulfill our mission.” This emphasis on purpose serves as a beacon for the entire team, fostering commitment, integrity and the relentless pursuit of outstanding customer experience. Empowering Access to Essential Healthcare Prasanna, leading Medvantx, spearheads efforts to empower access to essential medications and services in healthcare. “Since our inception, it’s all we’ve done,” affirms Prasanna. Medvantx’s extensive licensure allows the company to dispense prescriptions to all US states and some territories. A strategic partnership with UPS Healthcare has resulted in the industry’s first end-of-runway pharmacy offering extended hours, improving access to medications for patients across the nation. Medvantx surpasses industry standards to maintain medication temperatures during the fulfillment process. Internal protocols ensure that medications remain in a refrigerated environment for no more than 45 minutes, optimizing the effectiveness of cold- chain prescriptions upon delivery. “The world is overwhelmed with companies that do not advance from the standpoint of reinventing themselves,” he observes. Medvantx, however, remains steadfast in its commitment to redefining and advancing safe, effective care delivery. This entrepreneurial spirit, combined with a clear mission, attracts top talent With a remarkable track record of 99.99% accuracy in prescription fulfillment, Medvantx is recognized as

16. dedication to serving patients and its continuous efforts to innovate and improve services. Our dedication and priority of putting patients' well-being is our ?rst priority. These achievements not only validate Medvantx’s efforts but also strengthen its position as a trusted partner in the healthcare ecosystem. They reinforce the strong and credible relationships Medvantx has built with pharmaceutical manufacturers, device partners and healthcare providers. Enhancing Patient Access to Care In response to the digital revolution post-COVID, Medvantx has embraced digitization in healthcare, recognizing evolving consumer attitudes and expectations. The rise of e-commerce giants like Amazon reveals the shift towards convenient delivery models, setting new standards for access to care. Medvantx’s unique setup with UPS Healthcare enables efficient package delivery across the US and its territories, often on the same day, ensuring timely access to medications for patients nationwide. resources to address healthcare disparities and enhance access for underserved communities. Through these partnerships, Medvantx works to eliminate barriers at the point of care. Since its establishment, Medvantx has maintained a commitment to serving patients. With licenses to dispense prescriptions across all US states and territories, the company offers carrier solutions via UPS, FedEx and USPS at each pharmacy location. Through a strategic partnership with UPS, Medvantx introduced the industry’s first end-of-runway pharmacy, extending hours for patient convenience. By expanding its network and providing education and resources, Medvantx empowers patient literacy and increases awareness of patient assistance programs while remaining a trustworthy and reliable pharmacy partner. This enables the company to connect individuals with programs that facilitate access to medications. The digital revolution post-COVID has spurred consumer demand for healthcare digitization. Recognizing this shift, Medvantx prioritizes effective pharmacist-on-demand services, leveraging its partnership with UPS for efficient package delivery across the US and territories, often on the same day. Medvantx continues to innovate and expand its service offerings to support its mission of improving access to care. This includes further optimization of API solutions and the development of new innovative services tailored to the needs of pharma customers and the patients and providers they serve. Recent Milestones and Achievements Medvantx celebrates significant milestones and achievements in the pharmacy and healthcare industry. The company has secured prestigious awards for its leadership and commitment to increasing patient access to medications nationwide. These recognitions reinforce Medvantx’s position as a trusted partner, building strong relationships with pharmaceutical manufacturers and healthcare providers. “Enabled by our committed employees, scalable tech platform and partnerships, we believe we are uniquely positioned to serve our customers and transform lives and healthcare,” notes Prasanna. Collaboration to Address Healthcare Disparities One recent achievement that fills Medvantx with pride is being recognized by Global Health and Pharma as the “Best Non-Commercial Dispensing Pharmacy.” This accolade reflects Medvantx’s constant Collaborating with organizations such as NeedyMeds or Atlas Health, Medvantx leverages its expertise and

18. TruDoc TruDoc Redefining Healthcare with Innovation and Commitment A demand one-stop-care destination for healthy, acute, and chronic members, available anytime, anywhere. ccessibility and reliability are of utmost importance in healthcare and TruDoc is setting an example for other healthcare providers. It is an on- What sets TruDoc apart is not just its expansive network but the remarkable feat of zero malpractice claims. TruDoc envisions providing accessible, reliable, and quality healthcare to everyone, everywhere. At the heart of TruDoc's mission is a spectrum of services designed to redefine the healthcare delivery system. This includes 24x7 access to doctor consultations, unlimited follow-up care, teleconsultation services, and 24x7 telemonitoring, ensuring a constant presence when you need it the most. TruDoc is not merely a healthcare provider; it is a partner, always by your side. Taking this mission forward is Mahdi Attya the Chief Commercial Officer at TruDoc. He is a seasoned professional with over two decades of experience in the insurance industry. His leadership extends beyond steering the company; it is about sculpting a new paradigm in healthcare. In our exclusive interview with Mahdi, we dive into the exceptional work TruDoc is doing, making it a trusted name in the industry. Let us explore the journey of TruDoc, where healthcare is not just a service but a profound commitment to enhancing lives. Mahdi Attya Chief Commercial Officer Can you please provide some insights into your professional journey within the healthcare sector? TruDoc I have accumulated more than twenty years of extensive experience in the healthcare industry. My professional 16 June 2024 www.insightscare.com

19. Top Companies Empowering Access to Healthcare 2024 Our proactive strategy, through our Care Level Management system, involves early intervention to manage high-risk cases, aiming to prevent complications and improve outcomes. We leverage technology, like telemedicine, remote monitoring, wearables and data analytics, to enhance care and personalize treatment plans. journey is marked by a deep-seated passion for blending cutting-edge health solutions with established care practices. Throughout the last decade, I have led the charge in introducing telehealth initiatives, while also advocating for sustainable healthcare practices. My dedication to improving patient outcomes has been unwavering, driven by a commitment to innovative strategies that enhance healthcare delivery. This journey has not only been about adapting to change but also about leading it, ensuring that TruDoc remains at the forefront of healthcare innovation. What truly sets us apart is our team's dedication to providing exceptional care consistently. This commitment drives our continuous improvement, aiming to exceed quality expectations. In what ways does your healthcare enterprise embrace innovation and integrate technology to enhance medical services and patient outcomes? This journey over the years isn't just a career; it's a mission to transform healthcare insurance and control medical costs, building a future where quality care is accessible to all. In the same way that individuals embrace technology to enhance their daily lives, at TruDoc, we are committed to harnessing the power of these advancements. Our goal is not just to explore their novelty but to leverage their profound impact on health and well-being. Here's how this philosophy translates into our services: Could you give us a brief overview of your healthcare enterprise, highlighting its mission, core values, and the services it provides? TruDoc's Vision and Philosophy of Integrative Care Personalized Patient Care through AI Telehealth for Accessibility and Convenience Combining Human Touch with AI in Chronic Disease Management Wearable Technology for Real-Time Health Monitoring Cost-Effective Healthcare Solutions The philosophy revolves around the concept of integrative care. It's about seeing healthcare not as disparate elements but as a cohesive, interconnected system. This vision led to TruDoc's unique ecosystem that seamlessly blends primary care, diagnostics, and chronic disease management with the advancements of digital health. Ÿ Ÿ Ÿ Ÿ Ÿ How does your healthcare enterprise engage with the local community to address healthcare needs and promote public health awareness? Each step in this journey has been guided by a commitment to evidence-based medicine, ensuring that every decision, every innovation, is backed by solid research and proven outcomes, fostering a holistic approach that prioritizes patient well-being and sustainable healthcare. I deeply value the human element in healthcare. As technology evolves, it's vital to maintain a strong human connection, truly understanding each patient's journey, their fears, and aspirations. well-being. ‘‘ How does your organization prioritize and ensure the quality of care provided to patients? ‘‘ I appreciate the opportunity to discuss TruDoc's dedication to enhancing patient care, a mission that aligns closely with my core values. We're redefining healthcare with a focus on quality, effectiveness, and patient-centricity. Our goal is not just to explore their novelty but to leverage their profound impact on health and At the core of our approach is evidence-based medicine, ensuring our treatments are effective and prioritizing patient welfare. Our multidisciplinary team, including doctors, nurses, and support staff, collaborates to provide comprehensive care. 17 June 2024 www.insightscare.com

20. This philosophy is the cornerstone of our community engagement. We strive to be more than just healthcare providers; our goal is to form authentic relationships and cultivate a culture of health and wellness that's deeply embedded in the community. It's about becoming an integral part of the fabric of the communities we serve, resonating with our core values. have not only helped us overcome these challenges but also positioned us as pioneers in the healthcare sector. However, the biggest of all remains wider adoption of telehealth by the population, and we are working tirelessly with our partners to reach the level of adoption currently available in mature markets such as the US, though we have already been able to reach healthy levels, and the adoption is steadily rising on a monthly basis. We actively engage with local populations through meaningful initiatives and educational efforts. Our collaboration with various payors is focused on empowering individuals and addressing their unique health needs. This approach extends beyond mere awareness; it's about forging real connections and nurturing a culture of health and wellness at the community level. We utilize a mix of dynamic content, interactive events, and direct community involvement to make a tangible impact on health outcomes, serving over 1 million members in the UAE and 2 million+ globally. What is the future vision for your healthcare enterprise? Are there plans for expansion, introduction of new services, or collaborations on the horizon? So, it's fun when personal goals meet professional, and I will limit it to just one sentence: Touch the health of 10 million people by 2025 and deliver a sustainable healthcare ecosystem for patients and payors. What are some of the key challenges your healthcare organization has encountered, and how have you overcome them? More than a business plan; it's a commitment. This vision drives every decision we make and every action we take at TruDoc. My personal drive and ambition have been instrumental in overcoming key challenges. Adapting to the rapidly evolving healthcare technology and shifting patient expectations was a significant hurdle. We embraced a culture of continuous innovation, integrating advanced telehealth technologies and data-driven solutions to stay ahead. Balancing high-quality care with growing patient volumes required us to streamline our processes and invest in our team's development. We also tackled the challenge of sustainability, systematically embedding eco-friendly practices into our operations. These steps, fueled by the commitment of our entire leadership and TruDoc's vision, We have a clear path ahead of us, therefore stay tuned for exciting news in the coming months. Since TruDoc's acquisition by Pulsar Capital, the company has set its strategy to revolutionize the healthcare delivery system, to impact in a meaningful way the lives of the population (from preventative to acute and chronic) and bring value to the healthcare system which is currently facing great challenges linked to increased medical costs and insurance premiums. 18 June 2024 www.insightscare.com

22. Digital Twins in Healthcare Revolution?ing Patient Care Through Virtual Simulation D igital twins, virtual replicas of physical entities, are transforming the healthcare industry by enabling the simulation of patient outcomes and treatment plans. This advanced technology allows healthcare professionals to create personalized digital models of patients, which can be used to predict and optimize treatment strategies, ultimately leading to improved patient outcomes and more efficient healthcare delivery. 1. Personalized Treatment Plans: By creating a digital twin of a patient, healthcare professionals can develop tailored treatment plans that take into account the individual's unique characteristics and medical history. This level of personalization can lead to more effective treatments and better patient outcomes. Reduced Risk: Simulating patient outcomes using digital twins can help identify potential complications or adverse reactions to treatments, allowing healthcare professionals to mitigate risks and optimize treatment plans. This proactive approach to risk management can signifi- cantly improve patient safety and reduce the likelihood of medical errors. Improved Efficiency: Digital twins can streamline the healthcare process by reducing the need for costly and time-consuming clinical trials, as well as minimiz- ing the number of unnecessary procedures. By allowing healthcare providers to test and refine treatment strategies in a virtual environment, digital twins can help optimize resource allocation and improve overall healthcare efficiency. Enhanced Patient Engagement: By involving patients in the creation of their digital twins and sharing the simulation results, healthcare professionals can foster a greater sense of patient engagement and shared decision-making. This increased transparency and The Concept of Digital Twins in Healthcare 2. A digital twin in healthcare is a virtual representation of a patient, created using data from various sources, such as medical scans, genetic information, and electronic health records. This digital model can be used to simulate the patient's response to different treatments, allowing healthcare professionals to test various scenarios and make informed decisions about the most effective course of action. By leveraging advanced data analytics and modeling techniques, digital twins provide a comprehensive view of a patient's health status, medical history, and potential future outcomes. This holistic approach enables healthcare providers to move beyond traditional, reactive care models and embrace a more proactive, predictive approach to patient management. 3. 4. Benefits of Digital Twins in Healthcare The use of digital twins in healthcare offers numerous benefits, including: 20 June 2024 www.insightscare.com

23. 21 June 2024 www.insightscare.com

24. collaboration can lead to better patient understanding of their health conditions and treatment options, potentially improving adherence to treatment plans and overall health outcomes. maintaining patient trust and complying with regula- tory requirements. Interoperability: Ensuring that digital twin systems can seamlessly integrate with existing healthcare IT infrastructure is a significant challenge that must be addressed. The ability to share data and insights across different platforms and systems is essential for realizing the full potential of digital twin technology in healthcare. Validation and Regulation: As digital twins become more widely used in healthcare, there is a need for robust validation and regulatory frameworks to ensure their accuracy and safety. Developing standards and guidelines for the development, implementation, and use of digital twins in clinical settings will be crucial for their widespread adoption and acceptance. 2. Applications of Digital Twins in Healthcare Digital twins have various applications in healthcare, which includes: 3. 1. Surgical Planning: Digital twins can be used to create detailed simulations of surgical procedures, allowing surgeons to practice and refine their techniques before operating on a patient. This will ensure improved surgical outcomes, reduced complications, and shorter recovery times. Drug Development: Pharmaceutical companies can use digital twins to test the efficacy and safety of new drugs, reducing the time and cost associated with traditional drug development processes. By simulating drug interactions and effects in virtual patient models, researchers can identify potential issues earlier in the development cycle and focus resources on the most promising candidates. Chronic Disease Management: Digital twins can be used to monitor and manage chronic conditions, such as diabetes and heart disease, by tracking patient data and providing personalized recommendations for treatment and lifestyle changes. This ongoing monitor- ing and analysis can help healthcare providers identify early warning signs of disease progression and intervene proactively to prevent complications. Population Health: By aggregating data from multiple digital twins, healthcare organizations can gain insights into population health trends and develop targeted interventions to address specific health issues. This broader perspective can inform public health strategies and help allocate resources more effectively to address community health needs. 2. Conclusion The future of digital twins in healthcare holds immense promise. As the technology matures and becomes more sophisticated, we can expect to see even more innovative applications emerge. For instance, the integration of real- time data from wearable devices could further enhance the accuracy and predictive power of digital twins, providing an even more comprehensive view of patient health. 3. Moreover, the combination of digital twin technology with artificial intelligence and machine learning algorithms could unlock new possibilities in predictive analytics and personalized medicine. These advanced systems could analyze vast amounts of data to identify patterns and insights that might not be apparent to human observers, further enhancing our ability to predict and prevent health issues. 4. - Natalie May Challenges and Limitations While digital twins offer significant potential in healthcare, there are also challenges and limitations to their implemen- tation, including: 1. Data Privacy and Security: The use of digital twins requires the collection and storage of large amounts of sensitive patient data, which raises concerns about privacy and security. Ensuring the protection of this data from breaches or unauthorized access is crucial for 22 June 2024 www.insightscare.com

26. T his year on 29 February, the rarest day on the calendar, the rare disease community comes together to raise awareness for the 300 million people worldwide living with rare diseases. Rare Disease Day, observed every year on 28 February (or 29 in leap years), is the globally-coordinated movement on rare diseases, working towards equity in social opportunity, healthcare, and access to diagnosis and therapies for people living with a rare disease. • It is estimated that over 300 million people worldwide live with a rare disease, which illustrates the paradox of rare diseases: while each may affect a small population, together they account for up to 5% of the global population, equivalent to the population of the third largest country. • The majority of rare diseases, approximately 80%, have identified genetic origins, which means that many rare diseases are present throughout a person’s life, even if symptoms do not appear immediately. Created in 2008 and coordinated by EURORDIS and over 65 national alliance patient organisation partners, Rare Disease Day (RDD) has grown significantly, transforming from a European initiative into a global movement. What began as a campaign to elevate awareness about rare diseases and enhance access to treatments in Europe has expanded to take place in over 100 countries across the globe. This evolution has seen an increase in participant numbers, diversity in activities, expansion of its messages and objectives, and a better understanding of the conditions that are not well understood by clinicians, administrations, and policymakers. • Patients with rare diseases often face significant delays in diagnosis, with the average time to diagnosis being 5 years. The rarity and complexity of these conditions can lead to misdiagnosis or years without a definitive diagnosis, impacting treatment options and outcomes. • Rare diseases are significantly under-represented in medical research and drug development. Due to their low prevalence, there is often a lack of funding and interest in studying these diseases, leading to a scarcity of treatments. Currently, only a small fraction of rare diseases have approved treatments, leaving many patients with limited or no options. Key facts and figures Despite each rare disease affecting a relatively small number of people, collectively, they represent a significant global health challenge. Think global act locally! Rare Disease Day exemplifies the “think global, act locally” approach. It creates a focused period that allows patient groups to capture the public imagination and push for significant changes at various levels: At the heart of RDD's global strategy unified voice for rare diseases, drawing attention to the millions of people worldwide living with these conditions. • There are over being discovered regularly. These diseases encompass a wide range of complexities and symptoms, many of which are genetic in origin. The diversity of rare diseases makes them harder to diagnose, research, and treat, as each condition requires specialised knowledge and approaches. 6,000 rare diseases , with new conditions is the aim to create a 24 June 2024 www.insightscare.com

27. By fostering a sense of global solidarity, the campaign helps to bridge the gap between countries and communities, encouraging the exchange of knowledge, resources, and best practices. As a global platform, it aims to raise awareness and support efforts to put rare diseases on the international agenda. On a national level, RDD acts as a catalyst for policy change, with national partners advocating for the rights and needs of people with rare diseases. By mobilising patient organisations, healthcare professionals, researchers, and policymakers, RDD helps to highlight the specific challenges faced by the rare disease community within each country. This concerted effort is aimed at influencing health policies, securing funding for research, improving access to care, and ensuring that rare diseases are included in national health agendas. The success of RDD can be measured by the growing number of countries that have adopted relevant rare disease policies or strategies. Locally, RDD emphasises the importance of engaging communities directly to educate the public, healthcare providers, educators, and local officials about rare diseases. Through various activities such as school programmes, community events, and media campaigns, RDD seeks to demystify rare diseases, reduce stigma, and promote inclusion for people living with a rare disease. 25 June 2024 www.insightscare.com

28. Platform for sharing personal stories: One of the most impactful resources offered by RDD is the platform for sharing personal stories families living with rare diseases. These stories illustrate the personal struggles and triumphs within the rare disease community. These stories can be a powerful advocacy tool, helping to personalise the campaign, engage a broader audience and break the feeling of isolation often felt by our community. • These local actions play a critical role in building a supportive environment that can improve the quality of life for people and families impacted by rare diseases. By empowering local advocates and providing them with the tools and resources to raise awareness, the campaign ensures that the global message is translated into meaningful local impact. from people and Available resources to support the campaign Events: The campaign strongly encourages people and organisations to either host their own events participate in existing ones within their communities, to highlight and address the challenges faced by those living with rare diseases. • Today, countries, with over 1,000 events worldwide, showing its growth and global reach. The campaign now focuses on sharing personal stories, engaging with younger communities, and raising awareness among healthcare professionals, adopting a comprehensive approach to advocacy, education, and support for those impacted by rare diseases. Rare Disease Day boasts participation from 106 or Through shared stories and collective efforts, Rare Disease Day envisions a future where no one living with a rare disease is left behind. This , let’s come together in green, blue, Rare Disease Day purple, and pink to elevate awareness and drive change for the 300 million individuals living with a rare disease, their families, and caregivers worldwide, including the 30 million in Europe. To get involved, Rare Disease Day (RDD) provides a set of resources designed to support people, organisations, and communities in their efforts to raise awareness, advocate for policy change, and support those living with rare diseases. These include: • Educational materials: RDD offers a variety of educational materials, including infographics, and leaflets, aimed at increasing understanding and awareness of rare diseases among the general public, healthcare professionals, and policymakers. These materials are designed to provide key facts, best practices, and stories that highlight the challenges faced by people living with rare diseases. webinar recordings , School toolkits: RDD provides students of different ages aimed at increasing understanding of rare diseases among students, educators, and school communities. These toolkits include lesson plans, activities, and presentations tailored for different age groups, making it easier for educators to integrate rare disease awareness into their curriculum. • school toolkits for Digital assets: RDD makes available a range of digital assets, including logos, banners, and social media graphics that can be used to promote the Day online. Additionally, the Rare Disease Day campaign video with testimonies from people impacted by rare diseases from all over the world offers a powerful narrative that can be shared to foster understanding and incite action. • 26 June 2024 www.insightscare.com

30. 28 June 2024 www.insightscare.com

31. Virginia Spielmann is the Execu?ve Director of STAR Ins?tute for Sensory Processing, a 501(c)3 non- profit and the leading global organiza?on on therapy, educa?on, and research in sensory processing. STAR Ins?tute is based in Colorado, USA, and supports families from all over the world and all walks of life. Virginia is an Occupa?onal Therapist with a PhD in Infant and Early Childhood Development. Her extensive clinical experience includes au?sm, differences in sensory integra?on/processing, infant mental health, adop?on, developmental trauma, and physical disabili?es. She co-founded and authored the Cri?cal Core therapeu?c role-playing game and co-developed the Palaana sensory lounger with SLACK Lifestyle. Virginia is an author, researcher, interna?onal speaker and consultant, and in 2021 delivered the TEDx talk “Your Sensory Health Ma?ers: Here’s Why”. 29 June 2024 www.insightscare.com

32. Healthcare Transformation How TELEMEDICINE Bridges the Gap in Rural Healthcare? T have long struggled with limited access to quality medical services. By utilizing the power of digital technologies, telemedicine is breaking down geographical barriers and bringing specialized care to the doorsteps of rural residents. elemedicine has emerged as a transformative force in rural healthcare, offering a lifeline to communities that plans without leaving their communities. This increased access to specialized care is particularly crucial for complex medical conditions that require ongoing management or timely interven- tions. The impact of this improved access extends beyond convenience. Earlier diagnosis and treatment of complex conditions can significantly improve patient outcomes, reduce complications, and potentially save lives. Moreover, by reducing the need for travel, telemedicine eases the financial and logistical burdens on rural patients and their families, making specialized care more accessible and equitable. This innovative approach to healthcare delivery is not only improving access but also enhancing patient outcomes and overall community well- being. The Promise of Specialist Care Revolutionizing Chronic Disease Management One of the most significant advantages of telemedicine in rural settings is the unprece- dented access it provides to specialist care. Historically, rural communities have struggled to attract and retain medical specialists due to low population densities and limited resources. This shortage has often forced rural residents to embark on long, expensive journeys to urban centers for specialized consultations and treatments. Chronic diseases pose a significant challenge in rural healthcare, where regular in-person follow- ups can be difficult to maintain. Telemedicine offers a solution by enabling more frequent and convenient check-ups for patients with conditions such as diabetes, hypertension, and heart disease. Through virtual visits, healthcare providers can monitor patients' vital signs, adjust medications, and provide timely interventions. This proactive approach to chronic disease management helps prevent complications, reduces hospital admis- sions, and improves overall quality of life for patients. Additionally, the convenience of telemedicine consultations often leads to better treatment adherence, as patients are more likely to keep up with their care plans when barriers to access are removed. Telemedicine is changing this narrative by enabling virtual consultations with specialists located in distant hospitals or clinics. Through high-quality video conferencing and remote monitoring technologies, patients can now receive expert opinions and tailored treatment 30 June 2024 www.insightscare.com

33. TELEMEDICINE 31 June 2024 www.insightscare.com

34. Empowering Communities Through Preventive Care and Health Education One of the primary hurdles is the lack of reliable high-speed internet infrastructure in many rural areas. Without robust connectivity, the quality and reliability of telemedicine services can be compromised, limiting their effectiveness. Addressing this issue requires concerted efforts from governments, healthcare organizations, and telecommunica- tions providers to invest in rural broadband infrastructure. Telemedicine's role in rural healthcare extends beyond treatment to encompass preventive care and health educa- tion. Virtual platforms provide an excellent medium for delivering health education programs, conducting screen- ings, and promoting healthy behaviors. Another significant challenge is the need for comprehensive training and support for both healthcare providers and patients. Healthcare professionals must be equipped with the skills to effectively use telemedicine technologies and adapt their clinical practices to virtual settings. Similarly, patients need support and education to navigate telemedicine platforms and participate fully in virtual consultations. Through telemedicine, healthcare providers can reach a wider audience with targeted educational content on topics such as nutrition, exercise, and disease prevention. Virtual wellness programs and support groups can foster commu- nity engagement and empower rural residents to take an active role in their health. This focus on prevention and education has the potential to significantly impact public health in rural areas. By promoting healthier lifestyles and encouraging regular screenings, telemedicine can help reduce the incidence of preventable diseases and catch potential health issues early, when they are most treatable. User-friendly interfaces, clear instructions, and ongoing technical support are essential to overcoming these barriers and fostering greater acceptance of telemedicine among both providers and patients. Healthcare organizations must prioritize these aspects to ensure the smooth integration of telemedicine into rural healthcare delivery. Addressing Mental Health Disparities The Future of Rural Healthcare Mental health services have long been underserved in rural communities, due to both a shortage of mental health professionals and the stigma often associated with seeking care. Telemedicine is helping to bridge this gap through telepsychiatry and online therapy platforms. As technology continues to advance and healthcare systems adapt to the changing landscape, the role of telemedicine in rural healthcare will only grow more significant. Emerging technologies such as artificial intelligence, wearable devices, and 5G networks have the potential to further enhance the capabilities and reach of telemedicine services. Looking ahead, we can envision a future where rural residents have seamless access to a wide range of healthcare services, from routine check-ups to specialized consultations, all from the comfort of their communities. This vision of equitable healthcare access, regardless of geographic location, is within reach through the continued development and implementation of telemedicine solutions. These virtual mental health services offer rural residents a discreet and convenient way to access care, reducing barriers and improving treatment adherence. The privacy afforded by telemedicine can be particularly beneficial in small communities where concerns about confidentiality may deter people from seeking in-person mental health services. Moreover, telepsychiatry allows rural healthcare facilities to expand their mental health offerings without the need to recruit and retain on-site specialists. This increased access to mental health services can have profound effects on individual well-being and community health outcomes. - Natalie May Overcoming Implementation Challenges While the benefits of telemedicine in rural healthcare are clear, several challenges must be addressed to ensure its successful implementation and widespread adoption. 32 June 2024 www.insightscare.com