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Objectives

Objectives. Describe RCE’s with SERCEB as model Describe Programs and Opportunities of RCE’s Learn from RCMI. Acknowledgements. NIH, NIAID Bill Angus Fred Sparling, David Stephens, Richard Moyer, Richard Whitley, Jenny Ting, Barton Haynes Vanderbilt - George Hill and Steve Gabbe.

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Objectives

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  1. Objectives • Describe RCE’s with SERCEB as model • Describe Programs and Opportunities of RCE’s • Learn from RCMI

  2. Acknowledgements • NIH, NIAID • Bill Angus • Fred Sparling, David Stephens, Richard Moyer, Richard Whitley, Jenny Ting, Barton Haynes • Vanderbilt - George Hill and Steve Gabbe

  3. RCE - Regional Centers of Excellence in Emerging Infections and Biodefense • NIAID funded - 10 Regional Centers • Multi-institution, based on Public Health Regions • Multiple Organizational Strategies • GOAL: Diagnostics, Therapeutics and Vaccines for “Select Agent” Biothreats

  4. RCE - The “Charge” • Progress AND Products • Diagnostics, Drugs and Defense (vaccines) • Moving from basic science to product

  5. Duke • Emory • Florida • UAB • UNC • Vanderbilt

  6. SERCEB Components • Research Programs • Developmental Projects • Career Development • Core Programs • “Trans-RCE projects” • New Opportunities

  7. SERCEB Components • Poxvirus vaccines • Poxvirus therapeutics • Poxvirus pathogenesis • Anthrax spore formation • Innate immunity to emerging infections • Adaptive immunity to emerging infections • Research Programs • Term of award • Multiple investigators • Multiple institutions • Ongoing review

  8. SERCEB Components • Developmental Projects • 2 years, novel ideas • Develop external funding Tan Florida A Novel Method for Early Detection of Infectious Agents Pereboev UAB Dendritic Cell Targeted Antivirus Vaccine Aballay Duke Boosting Innate Immunity against Yersinia Pestis Frelinger UNC Identification of Pathogen Specific Immunostimulatory Targets Su UNC A Mouse Model to Study Human Immune Responses and Vaccines

  9. SERCEB Components • Antibodies and Detection • Protein Expression • Immune Monitoring • Policy Ethics and Law • Dual - Use • Program Review • Biosafety Committees • Policy Development • Research Programs • Developmental Projects • Career Development • Core Programs • “Trans-RCE projects” • New Opportunities

  10. SERCEB Components • Career Development • 1 year 50K • Sabbatical - new area • BSL3 and / or BSL4 • SERCEB or other Labs • Institutional Commitment • New or established

  11. SERCEB Components • Brian Youree MD - Vanderbilt • Medicine - ID • Poxvirus Receptors • Terry Dermody - Receptors • Richard Moyer - Poxvirus • Chuck Parkos - mAbs • Emory - BSL3 • Career Development • 1 year 50K • Sabbatical - new area • BSL3 and / or BSL4 • SERCEB or other Labs • Institutional Commitment • New or established

  12. SERCEB Training Goals • Develop innovative programs for training in research in emerging infections and select agents as a national resource • Sabbaticals for established investigators • Training and support for new investigators • BSL3, BSL4 training • Support to work in labs • Commitment of institutions to support investigators

  13. NIAID and NCCRRCE and RCMI • Clark Atlanta • Meharry • Morehouse • Jackson State • Florida A&M

  14. Bioterrorism and Health Disparities • Potential Targets to Metropolitan Areas • Disproportionate impact on underserved or underinsured? • Lack of preparation for events • Lack of education of public

  15. U.S. Commission on Civil Rights Bioterrorism and Health Care DisparitiesMarch 8, 2002 “The recent cases of anthrax contamination have raised numerous questions regarding the nation’s health care system, especially as it relates to the prompt emergency medical treatment of hundreds or perhaps thousands of individuals.” “Of special concern to the U.S. Commission on Civil Rights is equitable treatment for all groups regardless of socioeconomic status, English-language proficiency, ethnicity, or race.”

  16. SERCEB (RCE) Opportunities • Developmental Projects • Integration in current research programs • Career Development / Sabbatical • Special training BSL3, BSL4 • Impact on populations - Research or Events

  17. Learning from RCMI • Is biodefense research on your radar? • Do RCE initiatives augment or detract from your mission? • Are there RCMI trainees or investigators who would benefit? • Is the concept of disparities relevant to biodefense and emerging Infections research or preparedness?

  18. SERCEB initiatives with RCMI institutions • Support attendance of Institutional Leaders and investigators at SERCEB and national RCE meetings • Encourage new investigators, transitions, or sabbaticals • Sponsor national meeting • Biodefense and under-represented investigators • Impact of bioterrorism on underserved or underrepresented populations • Resources required for education and research in biodefense and emerging infections at RCMI institutions

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