Inmecin Capsules by Replica Remedies (Generic Indomethacin Capsules)

1. Inmecin Capsules by Replica Remedies (Generic Indomethacin Capsules) © The Swiss Pharmacy

2. Inmecin Capsules by Replica Remedies (Generic Indomethacin Capsules) Inmecin (Generic Indomethacin Capsules) is nonsteroidal anti-inflammatory medicine used for the treatment of moderate to severe rheumatoid arthritis including acute flares of chronic disease, moderate to severe ankylosing spondylitis, moderate to severe osteoarthritis, acute painful shoulder (bursitis and/or tendinitis) and acute gouty arthritis. © The Swiss Pharmacy

3. Inmecin Capsules by Replica Remedies (Generic Indomethacin Capsules) Inmecin Tablets are manufactured by Replica Remedies Private Limited, India in the strengths of 25 mg and 50 mg. © The Swiss Pharmacy

4. Inmecin Capsules by Replica Remedies (Generic Indomethacin Capsules) Chemical Structure © The Swiss Pharmacy

5. Inmecin Capsules by Replica Remedies (Generic Indomethacin Capsules) The active ingredient contained in Inmecin tablets is Indomethacin. Each Inmecin tablet contains 25 mg or 50 mg of Indomethacin. © The Swiss Pharmacy

6. Inmecin Capsules by Replica Remedies (Generic Indomethacin Capsules) Uses of Inmecin 25mg tablets: Inmecin (Generic Indomethacin Capsules) is a nonsteroidal anti- inflammatory drug (NSAID) used to treat mild to moderate acute pain and relieve symptoms of arthritis (osteoarthritis and rheumatoid arthritis) including acute flares of chronic disease or gout, such as inflammation, swelling, stiffness, and joint pain. However, Inmecin does not cure arthritis and will help you only as long as you continue to take it. Inmecin is also used to treat ankylosing spondylitis, which is a type of arthritis that affects the joints in the spine. This medicine may also be used to treat painful shoulder caused by bursitis or tendinitis. In certain conditions (such as arthritis), it may take up to 4 weeks when this medicine is taken regularly before you notice the full benefits. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9561_Indomethacin-Capsules.html https://www.theswisspharmacy.com/product_info.php?info=p9561_Indomethacin-Capsules.html © The Swiss Pharmacy

7. Inmecin Capsules by Replica Remedies (Generic Indomethacin Capsules) Recommended Adult Dosage Inmecin (Generic Indomethacin Capsules) for the treatment of moderate to severe rheumatoid arthritis including acute flares of chronic disease, moderate to severe ankylosing spondylitis and moderate to severe osteoarthritisis is 25 mg twice a day or three times a day. If this is well tolerated, increase the daily dosage by 25 mg or by 50 mg, if required by continuing symptoms, at weekly intervals until a satisfactory response is obtained or until a total daily dose of 150 to 200 mg is reached. Doses above this amount generally do not increase the effectiveness of the medication. The dose of Inmecin (Generic Indomethacin Capsules) URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9561_Indomethacin-Capsules.html https://www.theswisspharmacy.com/product_info.php?info=p9561_Indomethacin-Capsules.html © The Swiss Pharmacy

8. Inmecin Capsules by Replica Remedies (Generic Indomethacin Capsules) Recommended Adult Dosage Acute Painful Shoulder (Bursitis And/Or Tendinitis): Inmecin (Indomethacin capsules) 75 to 150 mg daily in 3 or 4 divided doses. The medicine should be discontinued after the signs and symptoms of inflammation have been controlled for several days. The usual course of treatment is 7 to 14 days. Acute Gouty Arthritis: Inmecin (Indomethacin capsules) 50 mg three times a day until pain is tolerable. The dose should then be rapidly reduced to complete cessation of the medication. Definite relief of pain has been reported within 2 to 4 hours. Tenderness and heat usually subside in 24 to 36 hours, and swelling gradually disappears in 3 to 5 days. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9561_Indomethacin-Capsules.html https://www.theswisspharmacy.com/product_info.php?info=p9561_Indomethacin-Capsules.html © The Swiss Pharmacy

9. Inmecin Capsules by Replica Remedies (Generic Indomethacin Capsules) Contraindications ➔Inmecin capsules are contraindicated in patients with a known hypersensitivity (e.g., anaphylactic reactions and serious skin reactions) to Indomethacin or any component of the tablet. ➔History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs. Severe, sometimes fatal, anaphylactic reactions to NSAIDs have been reported in such patients. ➔In the setting of coronary artery bypass graft (CABG) surgery. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9561_Indomethacin-Capsules.html https://www.theswisspharmacy.com/product_info.php?info=p9561_Indomethacin-Capsules.html © The Swiss Pharmacy

10. Inmecin Capsules by Replica Remedies (Generic Indomethacin Capsules) Storage Instructions Inmecin (Indomethacin capsules) have to be stored at controlled room temperature i.e. from 20°C to 25°C (68°F to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F). Keep this as well as all other medicines away from children and pets. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9561_Indomethacin-Capsules.html https://www.theswisspharmacy.com/product_info.php?info=p9561_Indomethacin-Capsules.html © The Swiss Pharmacy

11. Inmecin Capsules by Replica Remedies (Generic Indomethacin Capsules) Warnings Hepatotoxicity: Inform patients of warning signs and symptoms of hepatotoxicity. Discontinue if abnormal liver tests persist or worsen or if clinical signs and symptoms of liver disease develop. Hypertension: Patients taking some antihypertensive medications may have impaired response to these therapies when taking NSAIDs. Monitor blood pressure Heart Failure and Edema: Avoid use of Inmecin in patients with severe heart failure unless benefits are expected to outweigh risk of worsening heart failure. Anaphylactic Reactions: Seek emergency help if an anaphylactic reaction occurs. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9561_Indomethacin-Capsules.html https://www.theswisspharmacy.com/product_info.php?info=p9561_Indomethacin-Capsules.html © The Swiss Pharmacy

12. Inmecin Capsules by Replica Remedies (Generic Indomethacin Capsules) Warnings Renal Toxicity: Monitor renal function in patients with renal or hepatic impairment, heart failure, dehydration, or hypovolemia. Avoid use of Inmecin in patients with advanced renal disease unless benefits are expected to outweigh risk of worsening renal function Exacerbation of Asthma Related to Aspirin Sensitivity: Inmecin is contraindicated in patients with aspirin-sensitive asthma. Monitor patients with preexisting asthma (without aspirin sensitivity). Serious Skin Reactions: Discontinue Inmecin at first appearance of skin rash or other signs of hypersensitivity. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9561_Indomethacin-Capsules.html https://www.theswisspharmacy.com/product_info.php?info=p9561_Indomethacin-Capsules.html © The Swiss Pharmacy

13. Inmecin Capsules by Replica Remedies (Generic Indomethacin Capsules) Warnings Premature Closure of Fetal Ductus Arteriosus: Avoid use in pregnant women starting at 30 weeks gestation. Hematologic Toxicity: Monitor hemoglobin or hematocrit in patients with any signs or symptoms of anemia. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9561_Indomethacin-Capsules.html https://www.theswisspharmacy.com/product_info.php?info=p9561_Indomethacin-Capsules.html © The Swiss Pharmacy

14. Inmecin Capsules by Replica Remedies (Generic Indomethacin Capsules) Inmecin Capsules and Alcohol Do not drink alcohol while taking Indomethacin (Inmecin Capsules). Alcohol can increase your risk of stomach bleeding caused by Indomethacin. Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds. This is more likely if you have had a stomach ulcer in the past, you smoke or drink alcohol regularly, are over 60 years of age, are in poor health, or are using certain other medicines (eg, steroid medicine or a blood thinner). URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9561_Indomethacin-Capsules.html https://www.theswisspharmacy.com/product_info.php?info=p9561_Indomethacin-Capsules.html © The Swiss Pharmacy

15. Inmecin Capsules by Replica Remedies (Generic Indomethacin Capsules) Possible Side Effects Most common Indomethacin (Inmecin capsules) side effects with an incidence rate of greater than or equal to 3% were headache, dizziness, dyspepsia and nausea. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9561_Indomethacin-Capsules.html https://www.theswisspharmacy.com/product_info.php?info=p9561_Indomethacin-Capsules.html © The Swiss Pharmacy

16. Inmecin Capsules by Replica Remedies (Generic Indomethacin Capsules) Possible Side Effects The following side effects occurred in more than 1% of patients during clinical trials: Nausea with or without vomiting, dyspepsia (including indigestion, heartburn and epigastric pain), diarrhea, abdominal distress or pain, constipation, headache (11.7%), dizziness, vertigo, somnolence,depression and fatigue (including malaise and listlessness). URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9561_Indomethacin-Capsules.html https://www.theswisspharmacy.com/product_info.php?info=p9561_Indomethacin-Capsules.html © The Swiss Pharmacy

17. Inmecin Capsules by Replica Remedies (Generic Indomethacin Capsules) Inmecin Overdosage Symptoms following acute NSAID overdosages have been typically limited to lethargy, drowsiness, nausea, vomiting, and epigastric pain, which have been generally reversible with supportive care. Gastrointestinal bleeding has occurred. Hypertension, acute renal failure, respiratory depression, and coma have occurred, but were rare. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9561_Indomethacin-Capsules.html https://www.theswisspharmacy.com/product_info.php?info=p9561_Indomethacin-Capsules.html © The Swiss Pharmacy

18. Inmecin Capsules by Replica Remedies (Generic Indomethacin Capsules) Treatment of Inmecin Overdosage Patients should be managed with symptomatic and supportive care following an NSAID overdosage. There are no specific antidotes for Indomethacin (Inmecin capsules). Consider emesis and/or activated charcoal (60 to 100 grams in adults, 1 to 2 grams per kg of body weight in pediatric patients) and/or osmotic cathartic in symptomatic patients seen within four hours of ingestion or in patients with a large overdosage (5 to 10 times the recommended dosage). Forced diuresis, alkalinization of urine, hemodialysis, or hemoperfusion may not be useful due to high protein binding. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9561_Indomethacin-Capsules.html https://www.theswisspharmacy.com/product_info.php?info=p9561_Indomethacin-Capsules.html © The Swiss Pharmacy

19. Inmecin Capsules by Replica Remedies (Generic Indomethacin Capsules) Inmecin Capsules During Pregnancy Indomethacin (Inmecin capsules) has been classified by the US FDA as Pregnancy Category C (Pregnancy Category D If Indomethacin is taken during the third trimester of pregnancy). Use of NSAIDs, including Indomethacin capsules, during the third trimester of pregnancy increases the risk of premature closure of the fetal ductus arteriosus. Avoid use of NSAIDs, including indomethacin capsules, in pregnant women starting at 30 weeks of gestation (third trimester). There are no adequate and well-controlled studies of indomethacin capsules in pregnant women. Data from observational studies regarding potential embryofetal risks of NSAID use in women in the first or second trimesters of pregnancy are inconclusive. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9561_Indomethacin-Capsules.html https://www.theswisspharmacy.com/product_info.php?info=p9561_Indomethacin-Capsules.html © The Swiss Pharmacy

20. Inmecin Capsules by Replica Remedies (Generic Indomethacin Capsules) Inmecin Capsules During Nursing Based on available published clinical data, Indomethacin (Inmecin capsules) may be present in human milk. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. The developmental and health benefits of breastfeeding should be considered along with the mother's clinical need for Indomethacin (Inmecin capsules) and any potential adverse effects on the breastfed infant from the Inmecin capsules or from the underlying maternal condition. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9561_Indomethacin-Capsules.html https://www.theswisspharmacy.com/product_info.php?info=p9561_Indomethacin-Capsules.html © The Swiss Pharmacy

21. Inmecin Capsules by Replica Remedies (Generic Indomethacin Capsules) Inmecin Capsules Inmecin Capsules (Generic Indomethacin Capsules) are manufactured by Replica Remedies Private Limited, India. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9561_Indomethacin-Capsules.html https://www.theswisspharmacy.com/product_info.php?info=p9561_Indomethacin-Capsules.html © The Swiss Pharmacy