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Mental Illness and Neuroscience Discovery (MIND) Consortium Data

Mental Illness and Neuroscience Discovery (MIND) Consortium Data. Randy L. Gollub, MD, PhD Training Core PI, MGH. This dataset in perspective. Clinical N~380 subjects Schizophrenics + Matched controls. Reliability N = 10. MGH DTI. MIND Who?.

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Mental Illness and Neuroscience Discovery (MIND) Consortium Data

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  1. Mental Illness and Neuroscience Discovery (MIND) Consortium Data Randy L. Gollub, MD, PhD Training Core PI, MGH

  2. This dataset in perspective Clinical N~380 subjects Schizophrenics + Matched controls Reliability N = 10 MGH DTI

  3. MIND Who? MIND Clinical Imaging Consortium (MCIC) Partner Sites Harvard/Massachusetts General Hospital University of New Mexico University of Minnesota University of Iowa DOE Grant No. DE-FG02-99ER62764

  4. MIND MCIC Why? A federally funded multi-site consortium created to advance our understanding of schizophrenia by supporting the acquisition of clinical, cognitive, genetic, morphometric, diffusion weighted and functional neuroimaging data from schizophrenia patients and matched controls using a common experimental protocol.

  5. MIND What? • Two data sets • Reliability n =10 travelers to all 4 sites • Clinical n = 300+ Chronic and First Episode (FE) schizophrenics and matched controls • FE subjects and matched controls have follow-up data at 1 year (n = 46)

  6. MIND Reliability • Healthy control subjects (n = 10, age 27-60, 5 female) • Scanned twice at each site within 24 hour interval • T1, T2, DTI, and 4 fMRI task paradigms • Goal: calibrate for clinical study

  7. MIND Reliability DTI …

  8. MIND CICS Over 300 subjects, Chronic and FE pts with matched controls

  9. MIND MCIC DTI • Patients (FE + chronic) n = 115 • Controls n = 138 • Demographics available upon request

  10. MIND CICS DTI …

  11. MIND CICS Preliminary Results Freesurfer segmentation: Putamen Thalamus Hippocampus Amygdala Caudate Morrow, et al International Congress on Schizophrenia Research, 2007

  12. 1= Controls, 2= Chronic schizophrenia FreesurferHippocampal segmentation Log normalized volume vs. age

  13. * * * For Marty and Andy with Robust differences in fMRI activation indices between schizophrenic patients and controls Gollub et al, SFN 2007

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