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A1. A2. P-Akt Ser 473. MMP-9. P-p70S6K Thr389. b -actin. b -actin. 100. 100. 100. 100. 100. 100. 250. 250. 250. 250. 250. 250. 500. 500. 500. 500. 500. 500. DMSO. DMSO. DMSO. DMSO. DMSO. DMSO. GDC-0941 nM. GDC-0941 nM. GDC-0941 nM. GDC-0941 nM. GDC-0941 nM.
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A1 A2 P-Akt Ser 473 MMP-9 P-p70S6K Thr389 b-actin b-actin 100 100 100 100 100 100 250 250 250 250 250 250 500 500 500 500 500 500 DMSO DMSO DMSO DMSO DMSO DMSO GDC-0941 nM GDC-0941 nM GDC-0941 nM GDC-0941 nM GDC-0941 nM GDC-0941 nM B1 B2 P-Akt Ser 473 MMP-9 P-p70S6K Thr389 b-actin b-actin C1 C2 P-Akt Ser 473 MMP-9 P-p70S6K Thr389 b-actin b-actin Figure S4