1 / 20

Three Key Neurotransmitter Systems of Antidepressants

Three Key Neurotransmitter Systems of Antidepressants. Norepinephrine Dopamine Serotonine. Stahl S M, Essential Psychopharmacology (2000). 5-19. NOREPINEPHRINE RECEPTORS. presynaptic alpha 2 autoreceptor. postsynaptic alpha 2 receptor. alpha 1 receptor. postsynaptic beta 1 receptor.

ananda
Download Presentation

Three Key Neurotransmitter Systems of Antidepressants

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Three Key Neurotransmitter Systemsof Antidepressants • Norepinephrine • Dopamine • Serotonine

  2. Stahl S M, Essential Psychopharmacology (2000) 5-19 NOREPINEPHRINE RECEPTORS presynaptic alpha 2 autoreceptor postsynaptic alpha 2 receptor alpha 1 receptor postsynaptic beta 1 receptor

  3. DOPAMINE RECEPTORS Stahl S M, Essential Psychopharmacology (2000) 5--33 presynaptic autorecptor dopamine transporter D2 D3 D4 D1 D5

  4. SEROTONIN RECEPTORS Stahl S M, Essential Psychopharmacology (2000) 5--36 5HT1D autoreceptor alpha 2 hetero receptor serotonin transporter 5HT3 5HT4 5HT2C 5HTX 5HT2A 5HTY 5HTZ 5HT1A

  5. SSRI Pharmacological Profile Powerful 5HT disinhibition in key passways • from midbrain raphe to prefrontal cortex • from midbrain raphe to basal ganglia • from midbrain raphe to limbic cortex and hippocampus • from midbrain raphe to hypothalamus • from midbrain raphe to spinal cord

  6. Stahl S M, Essential Psychopharmacology (2000) 5--51 Serotonin Pathways Raphe Nucleus

  7. Frontal Cortex Mood Stahl S M, Essential Psychopharmacology (2000) 5--52

  8. Akathisia/ Agitation Basal Ganglia OCD Stahl S M, Essential Psychopharmacology (2000) 5--53

  9. Limbic Anxiety Stahl S M, Essential Psychopharmacology (2000) 5--54

  10. Hypothalamus Appetite/bulimia Stahl S M, Essential Psychopharmacology (2000) 5--55

  11. Sleep Centers Insomnia Stahl S M, Essential Psychopharmacology (2000) 5--56

  12. SEROTONIN RECEPTORS Stahl S M, Essential Psychopharmacology (2000) 5--36 5HT1D autoreceptor alpha 2 hetero receptor serotonin transporter 5HT3 5HT4 5HT2C 5HTX 5HT2A 5HTY 5HTZ 5HT1A

  13. Stahl S M, Essential Psychopharmacology (2000) 5-19 NOREPINEPHRINE RECEPTORS presynaptic alpha 2 autoreceptor postsynaptic alpha 2 receptor alpha 1 receptor postsynaptic beta 1 receptor

  14. 5HT brake 5HT accelerator Stahl S M, Essential Psychopharmacology (2000) 5--48 serotonin neuron postsynaptic alpha 2 hetero receptor presynaptic alpha 2 autoreceptor alpha 1 receptor presynaptic alpha 2 autoreceptor norepinephrine neuron

  15. 5HT1A anti- depressant anxiolytic sleep restoring anxiolytic 5HT2A no sexual dysfunction weight gain 5HT2C anxiolytic no nausea 5HT3 no GI problems Stahl S M, Essential Psychopharmacology (2000) 7-11

  16. H1 SRI TCA M1 NRI Stahl S M, Essential Psychopharmacology (2000) 6-27

  17. 5-HT1A • Antidepressant • Anxiolytic • Lowering temperature

  18. depression lifts SRI inserted depression lifts Stahl S M, Essential Psychopharmacology (2000) NRI inserted 6-28 6-29

  19. weight gain drowsiness H1 inserted blurred vision constipation LAXATIVE drowsiness dry mouth M1 inserted Stahl S M, Essential Psychopharmacology (2000) 6-30 6-31

  20. decreased blood pressure dizziness inserted Stahl S M, Essential Psychopharmacology (2000) 6-32

More Related