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2. Organization. 1: Introduction2: Quorum sensing controlled processes3: Quorum sensing molecules4: Quorum sensing in bacterial pathogenesis5: Inhibition of quorum sensing5.1 : Strategies for quorum sensing inhibition6: Conclusion and future perspectives. 3. Introduction. Quorum sensing is cell to cell signaling mechanism that enables the bacteria to collectively control gene expression. This type of bacterial communication is achieved only at higher cell densities. Bacteria r1145
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1. 1 Quorum Sensing as a Potential Antimicrobial Target
By
Navneet Rai
Research Scholar
School of Biosciences and Bioengineering
Indian Institute of Technology, Bombay
Powai, Mumbai 400 076
2. 2
3. 3 Introduction
4. 4 Cell density and quorum sensing
5. 5 Quorum sensing controlled processes
6. 6 Quorum sensing molecules
7. 7 Acyl-homoserine lactones (AHLs)
8. 8 Acyl-homoserine lactones (AHLs) cont….AHL mediated quorum sensing cycle
9. 9 Autoinducer peptides
10. 10 Autoinducer peptides cont… AIPs signaling mechanism in Bacillus subtilis
11. 11 Autoinducer-2 (AI-2)
12. 12 Autoinducer-2 (AI-2) cont…AI-2 controlled processes
13. 13 Quorum sensing in bacterial pathogenesis
14. 14 Quorum sensing in bacterial pathogenesis cont…Quorum sensing in P. aeruginosa
15. 15 Quorum sensing in P. aeruginosa cont..
16. 16 Inhibition of quorum sensing
17. 17 What is the need for Quorum sensing inhibitors ?
18. 18 Antibiotic resistance
19. 19 Strategies for quorum sensing inhibition
20. 20 Targeting signal generation
21. 21 Effect of substrate analogues on RhlI activity in P. aeruginosa
22. 22 Targeting AHL signal dissemination
23. 23 AiiA as antipathogenic agent
24. 24 Targeting the signal receptor
25. 25 Targeting the signal receptor cont….
26. 26 Conclusions and future perspectives
27. 27