1 / 20

DNA Mutations and Repair

DNA Mutations and Repair. Chapter 17. Detecting mutations with the AMES test. SUMMARY OF AMES TEST. AMES TEST. Saccharin Aflatoxin. 2-aminofluorene. Aflatoxin B1. DNA Repair: general characteristics. Double stranded DNA Redundancy of pathways. Types of DNA repair. Mismatch repair

anika-morris
Download Presentation

DNA Mutations and Repair

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. DNA Mutations and Repair Chapter 17

  2. Detecting mutations with the AMES test

  3. SUMMARY OF AMES TEST

  4. AMES TEST • Saccharin • Aflatoxin 2-aminofluorene

  5. Aflatoxin B1

  6. DNA Repair: general characteristics • Double stranded DNA • Redundancy of pathways

  7. Types of DNA repair • Mismatch repair • Direct Repair • Base-Excision Repair • Nucleotide Excision Repair

  8. Mismatch repair • Mut H • Recognize GATC hemi-methylation • Mut S • Mut L

  9. A closer look at mismatch repair

  10. DIRECT REVERSAL REPAIR Direct Repair

  11. BASE EXCISION REPAIR

  12. BASE EXCISION REPAIR

  13. Nucleotide Excision Repair

  14. Diseases of DNA repair!

  15. Xeroderma pigmentosum Autosomal recessive

  16. Hereditary Non-Polyposis Colon Cancer • HNPCC • 15% of all colon cancers

  17. Li-Fraumeni • P-53 mutation

More Related