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Scientific Sample Size Calculations and Statistical Analysis

Discovering the power needed for scientific observations, sample sizes for T cell activation & mice weight, and comparing arachnophobia and parasite infection in cane toads.

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Scientific Sample Size Calculations and Statistical Analysis

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  1. Exercises • Activated T cells • Providing the observed difference between WT and KO cells is of scientific interest, what sample size is needed to achieve a 80% power? • Mice weight • What sample size is needed to be able to spot a 10% difference with 80% power?

  2. Exercises • Arachnophobia • Is it as scary to look at the picture of a spider than at a real one? • Cane toad • Is the proportion of cane toads infected by intestinal parasites the same in 3 different areas of Queensland? • Neutrophils • Is there a difference between KO with/without treatment and WT?

  3. Activated T cells Answer: To achieve a power of 80%, you will need a total sample of 288 cells.

  4. Mice weight Answer: To be able to spot a 10% difference in the mice weight, at 80% power, you will need a sample n=7.

  5. Arachnophobia Answer: If you are arachnophobe, it is scarier to look at a real spider than at the picture of one (p=0.0310).

  6. Cane toad Answer: The proportion of cane toads infected by intestinal parasites varies significantly between the 3 different areas of Queensland (p=0.0015), the animals being more likely to be parasitized in Rockhampton and Mackay than in Bowen.

  7. Neutrophils Answer: There is a significant difference from WT for the first and third groups.

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