Welcome to the Molecular Medicine course!

1. Welcome to theMolecular Medicinecourse!

2. Registration • General information • Over-arching goals • Roll call • Course contents • Information about KS library • Coffee • Course evaluation HT 2012 • Study design (research application) • Seminar assignments • Teacher exchange • Final examination • Molecular Medicine - from bed to bench

3. Course leader: Rachel Fisher 08-517 732 45 rachel.fisher@ki.se Deputy course leader: Ewa Ehrenborg 08-517 761 91 ewa.ehrenborg@ki.se Teaching assistant: Louisa Cheung 08-517 732 21 louisa.cheung@ki.se Department of Medicine, Center for Molecular Medicine, Karolinska University Hospital, L8:02 Course administrator: Sofia Asp (Laila Leidersten) 073 744 19 21 sofia.asp@ki.se Course office: Department of Medicine, Unit for Internal Medicine, Karolinska University Hospital, A3:02 Office hours daily 8.00am - 3.00pm

4. Course office(marked in yellow) D1Lifts Up to floor 2 Nanna Svartz A3:02 Lifts KS main entrance

5. Over-arching goals • To integrate previously gained knowledge • To stimulate team work • To analyse, evaluate and interpret raw data • To design a study and write a research application • To provide “real life” experience

6. Roll call

7. Course set up • Lectures, usually 9am – 3pm (check venue!) • Labs/demonstrations/work shops • Group work (+ preparation time) • Seminar assignments (+ preparation time) • Revision • Final written examination: 13th January • Presentation of group work (research application) at end of course

8. Course contents (15 hp/ECTS) Specific areas • Circulation, ischemia, metabolic syndrome, diabetes • Respiration, asthma, allergy • Endocrinology • Gastroenterology • Pathology • Clinical immunology / Clinical chemistry Assignments etc. • Molecular biology lab • Research application • Seminar assignments • Workshops • Revision

9. Course literature • Text books from previous courses: physiology, pharmacology, biochemistry, molecular genetics, immunology • Hand outs • Lecture summary points (from lecturers) • Selected articles Does everyone want a paper copy of the hand outs?

10. Information about KS libraryMarie Källberg

11. Seminar assignments Lab “Methods in Molecular Biology” Lectures, demos, labs, exam Workshops Research plan

12. Labs and Demonstrations • Lab: “Methods in Molecular Biology – Theory and Practice” 12/11 (introduction) 26-28/11, 3-5/12 (lab) 9-11/12 (analysis + statistics) 17/12 (discussion + review) • Blood grouping lab (14-15/11) • Lung/allergy demonstration (19/11)not compulsory • Angiography demonstration (22/11)

13. Labs • You must bring your own lab coatCompulsory to have a lab coat to perform the labs • If you have lost the lab coat you were given when you started the Biomedicine Programme, you can buy a new one (380kr):http://www.g-ess.se/ Tel: 08-449 85 70 (Stuvsta + Bromma) • Some labs and demonstrations will be performed in active research labs/clinics- show consideration for those who work there

14. Course evaluation HT 2012 Good • Research application • Lab “Methods in Molecular Biology” • Seminar assignment • Work shops • Examination relevant • Course leaders/administration Mixed • Clinical emphasis • Lung/asthma/allergy demonstration • Lecturers Bad • Lack of a course text book/absent summary points • Work load too light

15. New for HT 2013 • Two seminar assignments • Teacher exchange • New workshop • Revision of lab “Methods in Molecular Biology” • Modification of research application • Lung/asthma/allergy demonstration voluntary

16. Workshops • 3 workshops: Atherosclerosis (7/11) Endocrinology (2/12) Clinical immunology (16/12) • Questions/discussion topics handed out in connection with relevant lectures • Self-study/discussion + review with teacher • Preparation for the exam

17. Evaluation of the course • We rely on your feedback to improve the course • Please give constructive feedback • Evaluation forms (online) • Cinema ticket voucher if all evaluation forms completed + submitted!

18. Course councils • With class representatives Thursday 21st November, 12 noon • With whole class Wednesday 15th January, 1 pm Who are the class representatives?

19. Forms of feedback reviewing progress with  students Round-table feedback  Methods in mol biol Research application feedback on seminar assignment & exam Peer-to-peer to edit and redraft  Methods in mol biol Pre-submission guidance and feedback  Research application Workshops feedforward assignments  Research application Informing about feedback whole-class feedback  Workshops Course councils and evaluations

20. Course language • All literature in English • Lectures in English • All assignments must be examined in English (written + verbal)

21. Research application • Group assignment • Choose a specific issue to focus on • Design a research project • Write a research application • Present the project orally • Answer questions • Team work • Realistic exercise

22. Research application:groups and topics • Groups 1-6 each split in 2 • 12 “subgroups” of 3-4 people • Each subgroup allocated a broad topic • Detailed project chosen by the subgroup • Discussions with and feed back from topic “mentor” and from Ewa E

23. MicroRNA and vascular disease Aneurysm Thyroid diseases Coagulation Inflammatory lung diseases Cell death in metabolism Immunological aspects of gastric disease Regenerative cardiology Allergy Diabetes and co-morbidities Vascular remodelling Inflammation in cardiovascular disease Research application – broad topics 2 topics/group, 3-4 people/research application

24. Research applicationtopic lottery

25. Research application:new for HT2013 • Include writing a “popular science” project summary • Early discussions/feed back - start with groups with topics relating to lectures at start of course → timetable issues regarding groups

26. Groups will be announced today/tomorrow

27. Seminar assignments • Two assignments • Handed out at in advance • Group or individual work / individual assessment • Research based aspects, requires independent work • Obtain appropriate information- lectures, discussions, web, articles ..… • Time scheduled to prepare answers • Examination in seminar format, in groups: No. 1 27th/29th November No. 2 5th/6th December • Grading = pass / fail

28. Teacher exchange • Terhi Heino – University of Turku, Finland • Seminar Assignment 2

29. Examination • Final examination: Monday 13th January Grades A-F Questions testing knowledge + understanding

30. Grading of the examination • F, Fx, E, D, C, B, A • Goal-based assessment • Evaluating the level of knowledge obtained not the amount of knowledge • F, Fx = fail • E = basic pass: identify, describe, list • C, D = pass with merit: compare, explain connections, analyse, apply • B, A = pass with distinction: theorise, hypothesise, reflect

31. One relevant aspect Several relevant independent aspects Integrated into a structure Generalized to new domain Extended abstract B, A Relational C, D Prestructural F Multistructural E Unistructural Fx

32. To pass the course … • The student must obtain a grade of at least E for the written examination (5 hp) • The student must also pass • the seminar assignments (3 hp) • the research application (3 hp) • all compulsory labs and demonstrations (4 hp)

33. Replacement assignments • When compulsory parts of the course are missed, there are replacement exercises • If written, these must be handed in by the last day of the course (17 January 2013) • Next opportunity for submission = next course (HT2014)

34. Use the web page! We will communicate with you via the web page

35. Molecular Medicine:from bed to bench • Important clinical contact • Translational research • Cross-disciplinary • “From bench to bed and back again”