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Eric Niederhoffer, Ph.D. SIU-SOM

ERG Review 2014. Eric Niederhoffer, Ph.D. SIU-SOM. What is the effect of diabetes on glycogen? What is the difference between the PFK2-F26BPase activity/regulation in the liver versus in the heart ? How is glucokinase regulated?

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Eric Niederhoffer, Ph.D. SIU-SOM

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  1. ERG Review 2014 Eric Niederhoffer, Ph.D. SIU-SOM

  2. What is the effect of diabetes on glycogen? What is the difference between the PFK2-F26BPase activity/regulation in the liver versus in the heart? How is glucokinase regulated? Do insulin and glucagon play a role in regulating pyruvate kinase and pyruvate dehydrogenase kinase? Outline

  3. Impact of Diabetes on Glycogen Glycogen breakdown Ep(ML) Glucagon (L) Insulin (ML) βAR cAMP IR PKA PKA AKT PDK-1 PPKP PPK PPaP PPb GSK-3P AKTP PKA PPKP GSK-3 Glycogen GS Glycogenesis GSPn PPaP UDP-Glc PrPase1P Glycogenolysis G1P PrPase1 Glc G6P Glycolysis ETC TCA

  4. Glucagon Ep Insulin F26BPase-PFK-2P Liver PKA PrPase2A F26BPase-PFK-2 F26BPase-PFK-2 Skeletal Muscle F6P↑ F6P↓ F26BPase-PFK-2 Ep Insulin F26BPase-PFK-2 PKA Heart ??? AKT/WISK F26BPaseP-PFK-2 F26BPase-PFK-2 Regulation Comparison

  5. Regulation of Glucokinase GLUT2 Glucose GLUT5 Fructose GK FK (KHK) G6P Cytosol PGI F6P F1P nucleus GK GK GKRP GKRP AMPK GKRP GKRPP

  6. Glucagon Ep also represses PFK synthesis Insulin Glc G6P F26BPase-PFK-2P PKA PrPase2A F6P F26BPase-PFK-2 F26BP F16BP ATP Cit Alanine PEP PKA PKP Pyr PDHK PDHP ATP NADH PDHPase Acetyl-CoA PrPase Regulation of Pyruvate and Pyruvate Dehydrogenase Kinase GK PFK-1 PK PDH

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