1 / 29

Cofactors and Coenzymes

Cofactors and Coenzymes. Cofactors. Groups or molecules (other than amino acid residues) which are important to catalysis Metals Coenzymes If tightly bound, it is called a prosthetic group Enzyme without prosthetic group (cofactor) Apoenzyme Enzyme with prosthetic group (cofactor)

boris
Download Presentation

Cofactors and Coenzymes

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Cofactors and Coenzymes

  2. Cofactors • Groups or molecules (other than amino acid residues) which are important to catalysis • Metals • Coenzymes • If tightly bound, it is called a prosthetic group • Enzyme without prosthetic group (cofactor) • Apoenzyme • Enzyme with prosthetic group (cofactor) • Holoenzyme

  3. Some common coenzymes Transfers Oxidation/Reduction Nicotinamide Adenine Dinucleotide (NAD+) Flavin Adenine Dinucleotide (FAD) Hydride ion (H-) Electrons Catalysis by Coenzymes

  4. Catalysis by Coenzymes Some common coenzymes • One carbon metabolism • Biotin • Tetrahydrofolate Transfers CO2 One carbon groups

  5. Catalysis by Coenzymes Some common coenzymes • Acyl groups and others • Coenzyme A • Lipoic acid • Thiamine pyrophosphate • Pyridoxal phosphate • 5’-Deoxyadenosyl-cobalamin Transfers Acyl groups Acyl groups Aldehydes Amino groups and amines Alkyl groups

  6. Vitamin Derived Coenzymes

  7. Vitamin Derived Coenzymes

  8. Examples of Coenzyme Catalysis Uncatalyzed reaction

  9. Examples of Coenzyme Catalysis Catalysis with pyridoxal phosphate (Vitamin B6 derivative) Schiff Base

  10. Examples of Coenzyme Catalysis

  11. Examples of Coenzyme Catalysis

  12. Examples of Coenzyme Catalysis Nicotinamide adenine dinucleotide and alcohol dehydrogenase NADH NAD+

  13. Examples of Coenzyme Catalysis

More Related