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Emerging Pandemic Threats Program Overview Laos PDR Preparatory Meeting Vientiane February 28, 2011. worldwide poultry outbreaks. worldwide human cases. Year. API Achievements 2005 - 2010: Faster detection times for poultry and wild bird outbreaks
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Emerging Pandemic Threats Program Overview Laos PDR Preparatory Meeting Vientiane February 28, 2011
worldwide poultry outbreaks worldwide human cases Year • API Achievements 2005 - 2010: • Faster detection times for poultry and wild bird outbreaks • Faster detection of bird outbreaks = earlier control measures • decreased outbreak size • fewer subsequent outbreaks • fewer people exposed to virus • With less human cases, fewer opportunities for virus to acquire ability to transmit efficiently from person to person Sources: OIE, FAO, and WHO reports through 8/3/10
If outbreak detection and control in animals is improved… …then disease detection and control in humans can be improved Animal cases Human cases Time Usual detection of cluster of human cases and start of control measures Number of cases Animal cases Human cases Time
Host Species: rats, bats, non-human primates • Pathogens: RNA viruses, coronaviruses, filoviruses, influenza A viruses, henipaviruses • Exposure: humans and livestock in-contact with wildlife; extractive industries; wildlife hunters, etc… Kate Jones et al (2008): Global trends in emerging infectious diseases: Nature, Vol 451.21
Emerging Pandemic Threats Program • Global 5 year program (FY2009-FY2014) • Objective: • Enhance country capacity to rapidly detect and respond to newly-emergent (and existing animal and human) infectious diseases • Operational in Laos PDR from 2011 • Building on previous platforms and relationships, including USAID’s Avian and Pandemic Influenza programs
Wildlife Pathogen Detection: • Identification of target pathogens in wildlife that threaten humans • Risk Determination: • Characterization of potential risk and method of transmission for specific diseases of animal origin • Outbreak Response: • Support for sustainable country-level response for disease control • Risk Reduction: • Promotion of actions that minimize or eliminate the potential for the emergence and spread of new disease threats
RESPOND Tufts University, DAI, University of Minn., Training and Resources Group, Ecology and Environment Inc. PREDICT Univ. California-Davis, Wildlife Conservation Society, EcoHealth Alliance, Smithsonian Instit., Global Viral Forecasting Initiative IDENTIFY FAO, WHO, OIE Laos PDR Government & Academic Partners PREVENT Academy for Educational Development US Centers for Disease Control and Prevention
Disease outbreak in wild animals Disease outbreak in domestic animals Disease outbreak in humans IDENTIFY timely laboratory confirmation Animal Amplification PREVENT minimizing “high risk” practices PREDICT forecasting and early detection CASES Cross-species transmission RESPOND early and effective control Human Amplification TIME
Next Steps: • Solicit input and hold technical consultations • Integration with Laos five-year plan for emerging infectious diseases and public health emergency preparedness and response (2011 – 2015) • Draft EPT/Laos work plan and implementation plan