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The road to DNA, its importance and structure. Griffith, Avery, Macleod 1944. Transformation: DNA could transform cells whereas proteins could not. Chargaff: 1947. Equal % of C and G Equal % of A and T. Hershey and Chase: 1952. Franklin’s X-ray crystallography: early 1950’s.
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Griffith, Avery, Macleod 1944 • Transformation: DNA could transform cells whereas proteins could not
Chargaff: 1947 • Equal % of C and G • Equal % of A and T
Franklin’s X-ray crystallography: early 1950’s Had to be able to crystalize molecule Regular pattern= helix
Waston and crick: 1953 • Double helix model
Messelson and Stahl: late 1950’s: Semi-conservative replication
DNA structure • Antiparallel: opposite directions
Complementary: base pairs • Always one purine (double ring) A or G • Always one pyrimidine (single ring) C or T • A/T only has two H bonds so it is easier to unzip.