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Diversity-based, model-guided construction of synthetic gene networks with predicted functions

Diversity-based, model-guided construction of synthetic gene networks with predicted functions. Tom Ellis, Xiao Wang & James J Collins. Outline. Introduction of System Biology Diversity-based, model-guided construction of synthetic gene networks with predicted functions Plug and play

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Diversity-based, model-guided construction of synthetic gene networks with predicted functions

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  1. Diversity-based, model-guided construction of synthetic gene networks with predicted functions VC Lab, Dept. of Computer Science, NTHU, Taiwan Tom Ellis, Xiao Wang & James J Collins

  2. Outline • Introduction of System Biology • Diversity-based, model-guided construction of synthetic gene networks with predicted functions • Plug and play • Experiment • Result VC Lab, Dept. of Computer Science, NTHU, Taiwan

  3. System Biology • Developing and implementing computational-experimental methods to reverse engineer and analyze gene regulatory network • Integrate—the soul • Information—the basis • Interference or control—the key • Modeling & theorizing dependence –the feature • Relationship to Synthetic Biology VC Lab, Dept. of Computer Science, NTHU, Taiwan

  4. Plug and Play • Problem • inadequately characterized • time-consuming post hoc tweak • Diversity-based, model-guided VC Lab, Dept. of Computer Science, NTHU, Taiwan

  5. Experiment(1/3) VC Lab, Dept. of Computer Science, NTHU, Taiwan

  6. Experiment(2/3) NFL X Y VC Lab, Dept. of Computer Science, NTHU, Taiwan Z

  7. Experiment(3/3) VC Lab, Dept. of Computer Science, NTHU, Taiwan

  8. Result VC Lab, Dept. of Computer Science, NTHU, Taiwan

  9. Discussion • Plug and play • Same position, different promoters →many component • in silico→front-end of gene network engineering VC Lab, Dept. of Computer Science, NTHU, Taiwan

  10. Reference • Scott J Dixon, Brenda J Andrews, and Charles Boone, Exploring the conservation of synthetic lethal genetic interaction networks, Communicative & Integrative Biology 2, 78-81(2009) • Marcel Tigges, Tatiana T. Marquez-Lago, JorgStelling& Martin Fussenegger, A tunable synthetic mammalian oscillator, Nature457, 309-312(2009) VC Lab, Dept. of Computer Science, NTHU, Taiwan

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