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Suppl. Fig. 1 GL-261 NS SMA-560 NS

Suppl. Fig. 2 RAD GL-261 SMA-560 Cil Merge Merge NHS-Biotin NHS-Biotin Nucleus Nucleus

Suppl. Fig. 3 A B

Suppl. Fig. 4 SMA-560 SC RAD Cil Stauro

Suppl. Fig. 5 GL-261 NS SMA-560 NS SMA-560 NS GL-261 NS 1 nM GLPG 1 nM GLPG 100 nM GLPG 100 nM GLPG 1 µM Cil 1 µM Cil 10 µM Cil 10 µM Cil RAD RAD DMSO DMSO pSmad2 pSmad2 actin actin

Suppl. Fig. 6 A 0 ng/ml TGF-β2 0 ng/ml TGF-β2 0 ng/ml TGF-β2 0 ng/ml TGF-β2 0 ng/ml TGF-β2 + SD-208 0 ng/ml TGF-β2 + SD-208 0 ng/ml TGF-β2 + SD-208 0 ng/ml TGF-β2 + SD-208 0.1 ng/ml TGF-β2 0.1 ng/ml TGF-β2 0.1 ng/ml TGF-β2 0.1 ng/ml TGF-β2 0.1 ng/ml TGF-β2 + SD-208 0.1 ng/ml TGF-β2 + SD-208 0.1 ng/ml TGF-β2 + SD-208 0.1 ng/ml TGF-β2 + SD-208 1 ng/ml TGF-β2 1 ng/ml TGF-β2 1 ng/ml TGF-β2 1 ng/ml TGF-β2 1 ng/ml TGF-β2 + SD-208 1 ng/ml TGF-β2 + SD-208 1 ng/ml TGF-β2 + SD-208 1 ng/ml TGF-β2 + SD-208 B 10 ng/ml TGF-β2 10 ng/ml TGF-β2 10 ng/ml TGF-β2 10 ng/ml TGF-β2 10 ng/ml TGF-β2 + SD-208 10 ng/ml TGF-β2 + SD-208 10 ng/ml TGF-β2 + SD-208 10 ng/ml TGF-β2 + SD-208

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