1 / 12

insilicoCell : an integrated platform for biological model development and analysis

insilicoCell : an integrated platform for biological model development and analysis. Thai Quang Tung Korea Institute of Science and Technology Information (KISTI). Dept . of Cyber environment, KISTI. Development of Next-Generation Cyber Research Environment

carlos-delaney
Download Presentation

insilicoCell : an integrated platform for biological model development and analysis

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. insilicoCell: an integrated platform for biological model development and analysis Thai Quang Tung Korea Institute of Science and Technology Information (KISTI)

  2. Dept. of Cyber environment, KISTI • Development of Next-Generation Cyber Research Environment • Development of an Advanced Science Education Hub • Development of Science Cloud Technology

  3. System biology • System biology aims at a (sub)system level understanding of biological process and networks

  4. System biology • Target systems: organisms, organs, tissues, signaling networks (molecular level)

  5. Why modeling? • Comprehend information • Reduce complexity, help understanding real systems • Explain biological phenomena • Virtual laboratory • Generating new hypotheses • Design new experiments

  6. Modeling process

  7. What computer can help? • Knowledge management • Search literature database (PubMed) for system interactions • Search gene/protein database for specific gene/protein functions • Computer simulation tools • Validate the model • Edit/create models • Dynamical analysis tools • Parameter estimation • Sensitivity analysis • Bifurcation analysis

  8. insilicoCell • System biologists need: • multiple tools, some are complex to used (command line) • literature, database searching • Tools are developed for desktop environment Interaction, reaction database Kinetic parameter database Systems biology workbench Biological model database • insilicoCellbrings: • Integration • Intuitive GUI • High performance computing SBML editor Model converter Time-course simulation Local sensitivity analysis Parameter estimation Global sensitivity analysis, robustness analysis Biological system modelers Bifurcation analysis

  9. System architecture

  10. Computational engine

  11. ezBioNet GUI

  12. Demo

More Related