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Replicative Aging: The Hayflick Limit

Replicative Aging: The Hayflick Limit. Watson’s Realization. The Linear Chromosome End-Replication Problem. Telomere Extension. Telomerase: Reverse Transcriptase & RNA Template for DNA. Telomerase: Reverse Transcriptase & RNA Template for DNA. Telomerase in Action. Video clip from Lodish.

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Replicative Aging: The Hayflick Limit

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  1. Telomerase

  2. Replicative Aging: The Hayflick Limit Telomerase

  3. Watson’s Realization Telomerase

  4. The Linear Chromosome End-Replication Problem Telomerase

  5. Telomere Extension Telomerase

  6. Telomerase: Reverse Transcriptase & RNA Template for DNA Telomerase

  7. Telomerase: Reverse Transcriptase & RNA Template for DNA Telomerase

  8. Telomerase in Action • Video clip from Lodish Telomerase

  9. Tetrahymena Thermophila Telomerase

  10. Telomeric Disruption  Illegitimate Chromosomal Associations Telomerase

  11. Number of Telomeric Repeats & Chromosomal Protection Telomerase

  12. Telomerase Knock-Out Experiments in Mice Telomerase

  13. Proliferative Potential Increases in Cells Expressing Telomerase Telomerase

  14. Telomerase Activation Contributes to Immortality: NIH 3T3 Cells Telomerase

  15. Telomerase’s Role in Cancer Telomerase

  16. Possibility for Therapy: Potential to Kill Happy Cancer Cells Telomerase

  17. References • Alberts, Bruce, et al.Essential Cell Biology. 2nd ed. New York: Garland Science, 2003 • Campbell, Neil, et al. Biology. 5th ed. New York: Benjamin Cummings, 1998. • Griffiths, Anthony J.F., et al.Modern Genetic Analysis: Integrating Genes and Genomes. 2nd ed. New York: W.H. Freeman, 2002. • Hahn, William C. “Role of Telomeres and Telomerase in the Pathogenesis of Human Cancer.” Journal of Clinical Oncology. Vol 21, No 10 (May 15), 2003: pp 2034-2043 • Immortalizing Human Cells with Telomerase. Shay, Jerry and Woodring Wright. BioInfo.org. 27 February 2005. <http://www.bioinfo.org.cn/book/Great%20Experments/great23.htm> • Landau, Misia. “Telomere Loss Spells Trouble for Aging Mice.” Focus 5 Mar. 1999. • Landes Bioscience. 25 February 2005. <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Search&db=books&doptcmdl=GenBookHL&term=telomere+ AND+eurekah%5Bbook%5D+AND+177962%5Buid%5D&rid=eurekah.figgrp.1569> • Lodish, Harvey, et al.Molecular Cell Biology. 5th ed. New York: W.H. Freeman, 2003 • Molecular Biology of the Gene. 25 February 2005. <http://www.bmb.psu.edu/courses/bmb400_fall2004/2_5_04_sup.ppt> • Samper, Enrique, Juana m. Flores, and Maria A. Blasco. “Restoration of telomerase activity rescues chromosomal instability and premature aging in Terc-/- mice with short telomeres.” Embo Reports Sep. 2001. 25 February 2005 <http://www.nature.com/cgi-taf/DynaPage.taf?file=/embor/journal/v2/n9/full/embor347.html> • Sara K. Evans and Victoria Lundblad. “Est1 and Cdc13 as Comediators of Telomerase Access.”Science 286 (1999): 117-120. • Tsukii, Y. Tetrahymena. <http://mtlab.biol.tsukuba.ac.jp/WWW/PDB/Images/Ciliophora/Tetrahymena/&h=381&w=560&sz=39&tbnid= LTeA9z-_p14J:&tbnh=89&tbnw=131&start=1&prev=/images%3Fq%3Dtetrahymena%2Bthermophila%26hl%3 Den%26lr%3D%26c2coff%3D1%26sa%3DG> • Wells, Samuel. Photograph. Molecular Probes, Inc Telomerase

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